In:
Journal of the American Geriatrics Society, Wiley, Vol. 62, No. 9 ( 2014-09), p. 1623-1629
Abstract:
To determine the association between cognition and levels of cystatin C in persons with chronic kidney disease ( CKD ). Design Prospective observational study. Setting Chronic Renal Insufficiency Cohort Cognitive Study. Participants Individuals with a baseline cognitive assessment completed at the same visit as serum cystatin C measurement (N = 821; mean age 64.9, 50.6% male, 48.6% white). Measurements Levels of serum cystatin C were categorized into tertiles; cognitive function was assessed using six neuropsychological tests. Scores on these tests were compared across tertiles of cystatin C using linear regression and logistic regression to examine the association between cystatin C level and cognitive performance (1 standard deviation difference from the mean). Results After multivariable adjustment for age, race, education, and medical comorbidities in linear models, higher levels of cystatin C were associated with worse cognition on the modified Mini‐Mental State Examination, Buschke Delayed Recall, Trail‐Making Test Part (Trails) A and Part B, and Boston Naming ( P 〈 .05 for all). This association remained statistically significant for Buschke Delayed Recall ( P = .01) and Trails A ( P = .03) after additional adjustment for estimated glomerular filtration rate (e GFR ). The highest tertile of cystatin C was associated with greater likelihood of poor performance on Trails A (odds ratio ( OR ) = 2.17, 95% confidence interval ( CI ) = 1.16–4.06), Trails B ( OR = 1.89, 95% CI = 1.09–3.27), and Boston Naming ( OR = 1.85, 95% CI = 1.07–3.19) than the lowest tertile after multivariate adjustment in logistic models. Conclusion In individuals with CKD, higher serum cystatin C levels were associated with worse cognition and greater likelihood of poor cognitive performance on attention, executive function, and naming. Cystatin C is a marker of cognitive impairment and may be associated with cognition independent of e GFR .
Type of Medium:
Online Resource
ISSN:
0002-8614
,
1532-5415
DOI:
10.1111/jgs.2014.62.issue-9
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2040494-3
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