In:
PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 5 ( 2021-5-5), p. e0251205-
Abstract:
Recent studies have reported disproportionate weight gain associated with integrase strand transfer inhibitor (INSTI) initiation in antiretroviral therapy(ART)-naive people with HIV (PWH), particularly among black women. We investigated if HIV-positive AGE h IV participants with suppressed viremia switching to INSTI-containing ART experienced more weight gain compared to HIV-positive virally-suppressed non-switching and HIV-negative controls. Methods In the AGE h IV cohort, standardized weight measurements were performed biennially. Participants switching to INSTI-containing ART were 1:2:2 propensity score-matched with controls by age, gender, ethnicity and body mass index. Mean weight changes and proportions experiencing 〉 5% or 〉 10% weight gain were compared between study-groups using linear mixed-effects models and logistic regression, respectively. Results 121 INSTI-switching participants and 242 participants from each of the control groups were selected. Across groups, median age was 53–55 years, 83–91% were male and 88–93% white. Mean weight change after switch among INSTI-switching participants was +0.14 kg/year (95%CI -0.25, +0.54) and similar among HIV-positive [+0.13 kg/year (95%CI +0.07, +0.33; P = .9)] and HIV-negative [+0.18 kg/year (95%CI 0.00, +0.37; P = .9)] controls. Weight gain 〉 5% occurred in 28 (23.1%) INSTI-switching, 38 HIV-positive (15.7%, P = .085) and 32 HIV-negative controls (13.2%, P = .018). Weight gain 〉 10% was rare. Conclusions Switching to INSTI-containing ART in our cohort of predominantly white men on long-term ART was not associated with greater mean weight gain, but 〉 5% weight gain was more common than in controls. These results suggest that not all, but only certain, PWH may be particularly prone to gain a clinically significant amount of weight as a result of switching to INSTI.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0251205
DOI:
10.1371/journal.pone.0251205.g001
DOI:
10.1371/journal.pone.0251205.g002
DOI:
10.1371/journal.pone.0251205.t001
DOI:
10.1371/journal.pone.0251205.t002
DOI:
10.1371/journal.pone.0251205.t003
DOI:
10.1371/journal.pone.0251205.s001
DOI:
10.1371/journal.pone.0251205.s002
DOI:
10.1371/journal.pone.0251205.s003
DOI:
10.1371/journal.pone.0251205.s004
DOI:
10.1371/journal.pone.0251205.s005
DOI:
10.1371/journal.pone.0251205.s006
DOI:
10.1371/journal.pone.0251205.r001
DOI:
10.1371/journal.pone.0251205.r002
DOI:
10.1371/journal.pone.0251205.r003
DOI:
10.1371/journal.pone.0251205.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2267670-3
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