In:
Helvetica Chimica Acta, Wiley, Vol. 74, No. 4 ( 1991-06-19), p. 892-898
Abstract:
The four protected diastereoisomcrs 7a / 7b and 8a / 8b P ‐thioadenylyl‐(3′–5′)‐ P ‐thioadenylyI‐(3′–5′)‐adenosine were synthesized, separated, and deblocked to the free oligonucleotides ( Scheme ). Biochemical characterization of these (3′–5′)phosphorothioate analogues of adenyiate trimer indicate that these compounds, and the corresponding 5′‐monophosphates, neither bind to nor activate RNase L, and are considered to be valuable control compounds in screening experiments.
Type of Medium:
Online Resource
ISSN:
0018-019X
,
1522-2675
DOI:
10.1002/hlca.19910740420
Language:
English
Publisher:
Wiley
Publication Date:
1991
detail.hit.zdb_id:
74-7
detail.hit.zdb_id:
1475013-2
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