In:
Clinical Transplantation, Wiley, Vol. 31, No. 3 ( 2017-03)
Abstract:
Drug‐induced acute liver failure ( ALF ) is associated with high mortality. There is limited literature on results of living donor liver transplantation ( LDLT ). Material and Methods The study was conducted at a tertiary care center in North India. All patients who received LDLT for drug‐induced ALF were included. The data are shown as median ( IQR ). Results A total of 18 patients (15 females and three males), aged 34 (25‐45) years, underwent LDLT for drug‐induced liver injury ( DILI )‐related ALF . Etiology of ALF was antitubercular medications (n=14), orlistat (n=1), flutamide (n=1), and complementary alternative medications (n=2). The baseline parameters were as following: bilirubin 17.7 (16.3‐23.8) mg/dL, INR 3.3 (2.5‐4.0), jaundice encephalopathy interval 6 (3‐17.5) days, arterial ammonia 109 μmol/L (73‐215), Model for End‐Stage Liver Disease ( MELD ) 24 (18‐33), grade of encephalopathy 2 (1‐4), which progressed to grade 3 (3‐4) before transplantation. All patients underwent right lobe LDLT ; hospital stay was 17 (13‐22) days, and ICU stay was 5 (5‐7) days. Two patients died in the first month after liver transplantation due to sepsis and multi‐organ failure; the rest of the patients are alive and doing well at a follow‐up of 50 (4‐82 months). Conclusion Good outcomes can be obtained by LDLT for drug‐induced ALF .
Type of Medium:
Online Resource
ISSN:
0902-0063
,
1399-0012
DOI:
10.1111/ctr.2017.31.issue-3
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
2739458-X
detail.hit.zdb_id:
2004801-4
Bookmarklink