In:
Journal of Heterocyclic Chemistry, Wiley, Vol. 54, No. 3 ( 2017-05), p. 1925-1930
Abstract:
A series of 6‐amino‐8‐aryl‐3,4‐dihydro‐1 H ‐spiro[naphthalene‐2,2'‐[1,3] dioxolane] ‐5,7‐dicarbonitrile and 8‐arylidene‐4‐aryl‐7,8‐dihydro‐5 H ‐spiro[quinazoline‐6,2'‐[1,3] dioxolan] ‐2‐amine derivatives have been synthesized from the reactions of 1,4‐dioxaspiro[4.5] decan‐8‐one, aromatic aldehydes, and malononitrile (or guanidine carbonate) under different conditions with high yields. In this research, it was found the DBU–THF was efficient reaction condition for obtaining 6‐amino‐8‐aryl‐3,4‐dihydro‐1 H ‐spiro[naphthalene‐2,2'‐[1,3]dioxolane] ‐5,7‐dicarbonitrile derivatives, while 95% EtOH and NaOH was the preferred condition for the synthesis of 8‐rylidene‐4‐aryl‐7,8‐dihydro‐5 H ‐spiro[quinazoline‐6,2'‐[1,3]dioxolan] ‐2‐amine derivatives. To the best of our knowledge, these Spiroheterocycles were first reported in our research. The other advantages of this process were short‐reaction time, wide scope substrates, and simple set‐up.
Type of Medium:
Online Resource
ISSN:
0022-152X
,
1943-5193
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
2042274-X
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