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  • Wiley  (6)
  • Zhang, Lei  (6)
  • 1
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    Online Resource
    Impaired robust interhemispheric function integration of depressive brain from REST‐meta‐MDD database in China
    Wiley ; 2022
    In:  Bipolar Disorders Vol. 24, No. 4 ( 2022-06), p. 400-411
    Details
    In: Bipolar Disorders, Wiley, Vol. 24, No. 4 ( 2022-06), p. 400-411
    Abstract: Recently, functional homotopy (FH) architecture, defined as robust functional connectivity (FC) between homotopic regions, has been frequently reported to be altered in MDD patients (MDDs) but with divergent locations. Methods In this study, we obtained resting‐state functional magnetic resonance imaging (R‐fMRI) data from 1004 MDDs (mean age, 33.88 years; age range, 18–60 years) and 898 matched healthy controls (HCs) from an aggregated dataset from 20 centers in China. We focused on interhemispheric function integration in MDDs and its correlation with clinical characteristics using voxel‐mirrored homotopic connectivity (VMHC) devised to inquire about FH patterns. Results As compared with HCs, MDDs showed decreased VMHC in visual, motor, somatosensory, limbic, angular gyrus, and cerebellum, particularly in posterior cingulate gyrus/precuneus (PCC/PCu) (false discovery rate [FDR] q  〈  0.002, z = −7.07). Further analysis observed that the reduction in SMG and insula was more prominent with age, of which SMG reflected such age‐related change in males instead of females. Besides, the reduction in MTG was found to be a male‐special abnormal pattern in MDDs. VMHC alterations were markedly related to episode type and illness severity. The higher Hamilton Depression Rating Scale score, the more apparent VMHC reduction in the primary visual cortex. First‐episode MDDs revealed stronger VMHC reduction in PCu relative to recurrent MDDs. Conclusions We confirmed a significant VMHC reduction in MDDs in broad areas, especially in PCC/PCu. This reduction was affected by gender, age, episode type, and illness severity. These findings suggest that the depressive brain tends to disconnect information exchange across hemispheres.
    Type of Medium: Online Resource
    ISSN: 1398-5647 , 1399-5618
    URL: Issue
    URL: Article
    DOI: 10.1111/bdi.v24.4
    DOI: 10.1111/bdi.13139
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2001157-X
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  • 2
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    Prediction of postpartum hemorrhage in pregnant women with immune thrombocytopenia: Development and validation of the MONITOR model in a nationwide multicenter study
    Wiley ; 2021
    In:  American Journal of Hematology Vol. 96, No. 5 ( 2021-05), p. 561-570
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    In: American Journal of Hematology, Wiley, Vol. 96, No. 5 ( 2021-05), p. 561-570
    Abstract: Globally, postpartum hemorrhage (PPH) is the leading cause of maternal death. Women with immune thrombocytopenia (ITP) are at increased risk of developing PPH. Early identification of PPH helps to prevent adverse outcomes, but is underused because clinicians do not have a tool to predict PPH for women with ITP. We therefore conducted a nationwide multicenter retrospective study to develop and validate a prediction model of PPH in patients with ITP. We included 432 pregnant women (677 pregnancies) with primary ITP from 18 academic tertiary centers in China from January 2008 to August 2018. A total of 157 (23.2%) pregnancies experienced PPH. The derivation cohort included 450 pregnancies. For the validation cohort, we included 117 pregnancies in the temporal validation cohort and 110 pregnancies in the geographical validation cohort. We assessed 25 clinical parameters as candidate predictors and used multivariable logistic regression to develop our prediction model. The final model included seven variables and was named MONITOR ( m aternal complication, WH O bleeding score, a n tepartum platelet transfusion, placental abnormal i ties, pla t elet count, previ o us uterine surgery, and p r imiparity). We established an easy‐to‐use risk heatmap and risk score of PPH based on the seven risk factors. We externally validated this model using both a temporal validation cohort and a geographical validation cohort. The MONITOR model had an AUC of 0.868 (95% CI 0.828–0.909) in internal validation, 0.869 (95% CI 0.802–0.937) in the temporal validation, and 0.811 (95% CI 0.713–0.908) in the geographical validation. Calibration plots demonstrated good agreement between MONITOR‐predicted probability and actual observation in both internal validation and external validation. Therefore, we developed and validated a very accurate prediction model for PPH. We hope that the model will contribute to more precise clinical care, decreased adverse outcomes, and better health care resource allocation.
    Type of Medium: Online Resource
    ISSN: 0361-8609 , 1096-8652
    URL: Issue
    URL: Article
    DOI: 10.1002/ajh.v96.5
    DOI: 10.1002/ajh.26134
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 1492749-4
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  • 3
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    Liver damage at admission is an independent prognostic factor for COVID ‐19
    Wiley ; 2020
    In:  Journal of Digestive Diseases Vol. 21, No. 9 ( 2020-09), p. 512-518
    Details
    In: Journal of Digestive Diseases, Wiley, Vol. 21, No. 9 ( 2020-09), p. 512-518
    Abstract: Abnormal liver function is a common form of extra‐pulmonary organ damage in patients with coronavirus disease 2019 (COVID‐19). Patients with severe COVID‐19 have a higher probability and progression of liver injury than those without severe disease. We aimed to evaluate the prognosis of liver injury in patients with COVID‐19. Methods We retrospectively included 502 patients with laboratory‐confirmed SARS‐CoV‐2 infection. Clinical features and survival of patients with and without liver injury were compared. Cox proportional hazards models were used to determine the variables that might have an effect on survival. Results Among the 502 patients enrolled, 301 patients had abnormal liver function with increased neutrophil count, C‐reactive protein, creatinine, troponin I (TnI), D‐dimer, lactose dehydrogenase and creatine kinase. Patients with abnormal liver functions had a higher mortality rate (28.9% vs 9.0%, P   〈  0.001), a higher ratio of male sex (65.1% vs 40.8%, P   〈  0.001) and a higher chance of developing systemic inflammatory response syndrome (53.5% vs 41.3%, P = 0.007). Among patients with abnormal liver functions, patients with grade 2 liver damage (with both abnormal alanine aminotransferase or aspartate aminotransferase levels and abnormal alkaline phosphatase or gamma‐glutamyl transpeptidase levels) had a higher ratio of male patients, elevated neutrophil count, procalcitonin, D‐dimer levels and mortality rate. Multivariate Cox regression analyses suggested that the grade of liver damage (hazard ratio: 1.377, 95% confidence interval: 1.000‐1.896, P = 0.049) was an independent predictor of death. Conclusions Patients with COVID‐19 and abnormal liver functions have a higher mortality than those with normal liver functions. Liver damage is an independent prognostic factor of COVID‐19.
    Type of Medium: Online Resource
    ISSN: 1751-2972 , 1751-2980
    URL: Issue
    URL: Article
    DOI: 10.1111/cdd.v21.9
    DOI: 10.1111/1751-2980.12925
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2317117-0
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  • 4
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    Spatiotemporal variations of magnetic susceptibility in the deep gray matter nuclei from 1 month to 6 years: A quantitative susceptibility mapping study
    Wiley ; 2019
    In:  Journal of Magnetic Resonance Imaging Vol. 49, No. 6 ( 2019-06), p. 1600-1609
    Details
    In: Journal of Magnetic Resonance Imaging, Wiley, Vol. 49, No. 6 ( 2019-06), p. 1600-1609
    Abstract: Quantitative susceptibility mapping (QSM) is emerging as a technique that quantifies the paramagnetic nonheme iron in brain tissue. Brain iron quantification during early development provides insights into the underlying mechanism of brain maturation. Purpose To quantify the spatiotemporal variations of brain iron‐related magnetic susceptibility in deep gray matter nuclei during early development by using QSM. Study Type Retrospective. Subjects Eighty‐seven infants and children aged 1 month to 6 years. Field Strength/Sequence Enhanced T 2 *‐weighted angiography using a 3D gradient‐echo sequence at 3.0T. Assessment QSM was calculated by modified sophisticated harmonic artifact reduction for phase data and sparse linear equations and sparse least squares‐based algorithm. Means of susceptibility in deep gray matter nuclei (caudate nucleus, putamen, globus pallidus, thalamus) relative to that in splenium of corpus callosum were measured. Statistical Tests Relationships of mean susceptibility with age and referenced iron concentration were tested by Pearson correlation. Differences of mean susceptibility between the selected nuclei in each age group were compared by one‐way analysis of variance (ANOVA) and Fisher's Linear Significant Difference (LSD) test. Results Positive correlations of susceptibility with both referenced iron concentration and age were found ( P 〈 0.0001); particularly, globus pallidus showed the highest correlation with age (correlation coefficient, 0.882; slope, 1.203; P 〈 0.001) and greatest susceptibility ( P 〈 0.05) among the selected nuclei. Data Conclusion QSM allows the feasible quantification of iron deposition in deep gray matter nuclei in infants and young children, which exhibited gradual accumulation at different speeds. The fastest and highest iron accumulation was observed in the globus pallidus with increasing age during early development. Level of Evidence: 4 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018.
    Type of Medium: Online Resource
    ISSN: 1053-1807 , 1522-2586
    URL: Issue
    URL: Article
    DOI: 10.1002/jmri.v49.6
    DOI: 10.1002/jmri.26579
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 1497154-9
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  • 5
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    Running exercise protects spinophilin‐immunoreactive puncta and neurons in the medial prefrontal cortex of APP/PS1 transgenic mice
    Wiley ; 2022
    In:  Journal of Comparative Neurology Vol. 530, No. 6 ( 2022-04), p. 858-870
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    In: Journal of Comparative Neurology, Wiley, Vol. 530, No. 6 ( 2022-04), p. 858-870
    Abstract: The medial prefrontal cortex (mPFC) is thought to be closely associated with emotional processes, decision making, and memory. Previous studies have identified the prefrontal cortex as one of the most vulnerable brain regions in Alzheimer's disease (AD). Running exercise has widely been recognized as a simple and effective method of physical activity that enhances brain function and slows the progression of AD. However, the effect of exercise on the mPFC of AD is unclear. To address these issues, we investigated the effects of 4 months of exercise on the numbers of spinophilin‐immunoreactive puncta and neurons in the mPFC of 12‐month‐old APPswe/PSEN1dE9 (APP/PS1) transgenic AD model mice using stereological methods. The spatial learning and memory abilities of mice were tested using the Morris water maze. Four months of running exercise delayed declines in spatial learning and memory abilities. The stereological results showed significantly lower numbers of spinophilin‐immunoreactive puncta and neurons in the mPFC of APP/PS1 mice than in the wild‐type control group. The numbers of spinophilin‐immunoreactive puncta and neurons in the mPFC of running APP/PS1 mice were significantly greater than those in the APP/PS1 control mice. In addition, running‐induced improvements in spatial learning and memory were significantly associated with running‐induced increases in spinophilin‐immunoreactive puncta and neurons numbers in the mPFC. Running exercise could delay the loss of spinophilin‐immunoreactive puncta and neurons in the mPFC of APP/PS1 mice. This finding might provide an important structural basis for exercise‐induced improvements in the spatial learning and memory abilities of individuals with AD.
    Type of Medium: Online Resource
    ISSN: 0021-9967 , 1096-9861
    URL: Issue
    URL: Article
    DOI: 10.1002/cne.v530.6
    DOI: 10.1002/cne.25252
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1474879-4
    SSG: 12
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  • 6
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    Highly Selective Binding and Inhibition of Pyr‐His‐Pro‐NH 2 (TRH) Function using a Polypyridinyl Macrocyclic Receptor with an Amphiphilic Cavity
    Wiley ; 2020
    In:  Chemistry – A European Journal Vol. 26, No. 43 ( 2020-08-03), p. 9466-9470
    Details
    In: Chemistry – A European Journal, Wiley, Vol. 26, No. 43 ( 2020-08-03), p. 9466-9470
    Abstract: Macrocycle, cyclo[4] [(1,3‐(4,6)‐dimethylbezene)[4] (2,6‐(3,5)‐dimethylpyridine ( B4P4 ), shows highly selective binding affinity with protirelin (Pyr‐His‐Pro‐NH 2 ; TRH) among the tested 26 drug or drug adductive substrates. The stable complexation in a 1:1 manner was fully characterized in solution, gas phase, and solid state study. Furthermore, B4P4 acts as an efficient TRH inhibitor even at [macrocycle]:[drug] 〈 1:300, both in membrane transport and cellar incubation. The current work provides an unprecedented strategy for macrocycles to be efficiently used in drug target therapy.
    Type of Medium: Online Resource
    ISSN: 0947-6539 , 1521-3765
    URL: Issue
    URL: Article
    DOI: 10.1002/chem.v26.43
    DOI: 10.1002/chem.202000888
    RVK:
    VA 1120 ; VA 3507
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 1478547-X
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