In:
Nanomedicine, Future Medicine Ltd, Vol. 11, No. 11 ( 2016-06), p. 1417-1430
Abstract:
Autophagy is an essential lysosome-dependent process that controls the quality of the cytoplasm and maintains cellular homeostasis, and dysfunction of this protein degradation system is correlated with various disorders. A growing body of evidence suggests that nanomaterials (NMs) have autophagy-modulating effects, thus predicting a valuable and promising application potential of NMs in the diagnosis and treatment of autophagy-related diseases. NMs exhibit unique physical, chemical and biofunctional properties, which may endow NMs with capabilities to modulate autophagy via various mechanisms. The present review highlights the impacts of various NMs on autophagy and their functional consequences. The possible underlying mechanisms for NM-modulated autophagy are also discussed.
Type of Medium:
Online Resource
ISSN:
1743-5889
,
1748-6963
DOI:
10.2217/nnm-2016-0040
Language:
English
Publisher:
Future Medicine Ltd
Publication Date:
2016
SSG:
15,3
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