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  • Acoustical Society of America (ASA)  (62)
  • de Jong, Nico  (62)
  • Comparative Studies. Non-European Languages/Literatures  (62)
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  • Acoustical Society of America (ASA)  (62)
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  • Comparative Studies. Non-European Languages/Literatures  (62)
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  • 1
    Online Resource
    Online Resource
    A Fresnel-inspired approach for steering and focusing of pulsed transmit beams by matrix array transducers
    Acoustical Society of America (ASA) ; 2017
    In:  The Journal of the Acoustical Society of America Vol. 141, No. 5_Supplement ( 2017-05-01), p. 3611-3612
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 141, No. 5_Supplement ( 2017-05-01), p. 3611-3612
    Abstract: Matrix ultrasound transducers for medical diagnostic purposes are commercially available for a decade. A typical matrix transducer contains 1000 + elements, with a trend towards more and smaller elements. This number renders direct connection of each individual element to an ultrasound machine impractical. Consequently, it is cumbersome to employ traditional focusing and beamforming approaches that are based on transmit and receive signals having an individual time delay for each element. To reduce cable count during receive, one approach is to apply sub-arrays that locally combine the element signals using programmable delay-and-sum hardware, resulting in reduction by a factor 10. In transmit, achieving cable count reduction while keeping focusing and steering capabilities turns problematic once it becomes impossible to locally equip each element with its own high voltage pulser. To overcome this bottleneck for decreasing element size, here we present a Fresnel-inspired hardware and beam forming approach that is based on transmit pulses consisting of several periods of an oscillating waveform. These will be derived from one oscillating high voltage signal by using local switching and timing hardware. To demonstrate the feasibilities of our approach, we will show beam profiles and images for a miniature matrix transducer that we are currently developing.
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/1.4987739
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2017
    detail.hit.zdb_id: 1461063-2
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  • 2
    Online Resource
    Online Resource
    The spatial distribution of the ligand on targeted microbubbles influences the binding efficacy
    Acoustical Society of America (ASA) ; 2022
    In:  The Journal of the Acoustical Society of America Vol. 151, No. 4_Supplement ( 2022-04-01), p. A154-A154
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 151, No. 4_Supplement ( 2022-04-01), p. A154-A154
    Abstract: An important trait of targeted microbubbles is their binding to biomarkers for ultrasound molecular imaging and drug delivery. Using organic solvents in phospholipid-coated microbubble production results in a homogeneous ligand distribution, while dispersion of lipids directly into aqueous medium results in a heterogeneous ligand distribution. In this study, we compared the binding efficacy of ανβ3-targeted microbubbles with a homogeneous or heterogeneous ligand distribution in vitro and in vivo using confocal microscopy. For in vitro studies, human umbilical vein endothelial cells grown statically and under physiological flow were used. For in vivo studies, chicken embryos (day 5) were used. Microbubbles having a homogeneous ligand distribution bound 1.55× more than microbubbles having a heterogeneous ligand distribution in vitro statically, while in vitro under flow this was 1.49× more at 1.25 dyn/cm2 and 1.56× more at 2.22 dyn/cm2; in vivo this was 1.25× more. The dissociation rate in vitro was lower for bound microbubbles with a homogeneous than heterogeneous ligand distribution at low shear stresses (1–5 dyn/cm2). In conclusion, when producing phospholipid-coated targeted microbubbles using organic solvents is preferable over directly dispersing phospholipids in aqueous medium for optimal binding. [Funding by the Phospholipid Research Center (No. KKO-2017-057/1-1) and NWO (VIDI Project No.17543) is gratefully acknowledged.]
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/10.0010949
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2022
    detail.hit.zdb_id: 1461063-2
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  • 3
    Online Resource
    Online Resource
    Radial excursions of bound and non-bound targeted lipid-coated single microbubbles
    Acoustical Society of America (ASA) ; 2015
    In:  Journal of the Acoustical Society of America Vol. 137, No. 4_Supplement ( 2015-04-01), p. 2252-2253
    Details
    In: Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 137, No. 4_Supplement ( 2015-04-01), p. 2252-2253
    Abstract: One of the main challenges for ultrasound molecular imaging is acoustically distinguishing non-bound microbubbles from those that have bound to their molecular target. We previously showed that biotinylated DPPC-based microbubbles (16 C-atoms) had a larger binding area and a more domed shape when bound to a streptavidin-coated surface than DSPC-based microbubbles (18 C-atoms) [1]. In the present in vitro study, we used the Brandaris 128 ultrahigh-speed camera (~15 Mfps) to compare the acoustical responses of biotinylated DPPC and DSPC-based microbubbles in a non-bound configuration and bound to a streptavidin-coated membrane, aiming to acoustically discriminate them from each other. The microbubbles were driven at a pressure of 50 kPa and at frequencies between 1 and 4 MHz. The main difference between bound and non-bound microbubbles was the lower radial excursion at the fundamental frequency for bound microbubbles. Resonance frequencies and subharmonic responses were the same for bound and non-bound microbubbles. Finally, at the second harmonic frequency, we found higher relative radial excursions for bound DSPC-based microbubbles than for non-bound DSPC microbubbles, whilst there was no difference for DPPC-based microbubbles. This might provide opportunities to acoustically discriminate bound from non-bound DSPC microbubbles. [1] Kooiman et al., Eur. J. Lipid Sci. Technol. (2014).
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/1.4920215
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2015
    detail.hit.zdb_id: 1461063-2
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  • 4
    Online Resource
    Online Resource
    Impulse response method for characterization of echogenic liposomes
    Acoustical Society of America (ASA) ; 2015
    In:  The Journal of the Acoustical Society of America Vol. 137, No. 4 ( 2015-04-01), p. 1693-1703
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 137, No. 4 ( 2015-04-01), p. 1693-1703
    Abstract: An optical characterization method is presented based on the use of the impulse response to characterize the damping imparted by the shell of an air-filled ultrasound contrast agent (UCA). The interfacial shell viscosity was estimated based on the unforced decaying response of individual echogenic liposomes (ELIP) exposed to a broadband acoustic impulse excitation. Radius versus time response was measured optically based on recordings acquired using an ultra-high-speed camera. The method provided an efficient approach that enabled statistical measurements on 106 individual ELIP. A decrease in shell viscosity, from 2.1 × 10−8 to 2.5 × 10−9 kg/s, was observed with increasing dilatation rate, from 0.5 × 106 to 1 × 107 s−1. This nonlinear behavior has been reported in other studies of lipid-shelled UCAs and is consistent with rheological shear-thinning. The measured shell viscosity for the ELIP formulation used in this study [κs = (2.1 ± 1.0) × 10−8 kg/s] was in quantitative agreement with previously reported values on a population of ELIP and is consistent with other lipid-shelled UCAs. The acoustic response of ELIP therefore is similar to other lipid-shelled UCAs despite loading with air instead of perfluorocarbon gas. The methods described here can provide an accurate estimate of the shell viscosity and damping for individual UCA microbubbles.
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/1.4916277
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2015
    detail.hit.zdb_id: 1461063-2
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  • 5
    Online Resource
    Online Resource
    Microbubble spectroscopy of ultrasound contrast agents
    Acoustical Society of America (ASA) ; 2007
    In:  The Journal of the Acoustical Society of America Vol. 121, No. 1 ( 2007-01-01), p. 648-656
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 121, No. 1 ( 2007-01-01), p. 648-656
    Abstract: A new optical characterization of the behavior of single ultrasound contrast bubbles is presented. The method consists of insonifying individual bubbles several times successively sweeping the applied frequency, and to record movies of the bubble response up to 25 million frames/s with an ultrahigh speed camera operated in a segmented mode. The method, termed microbubble spectroscopy, enables to reconstruct a resonance curve in a single run. The data is analyzed through a linearized model for coated bubbles. The results confirm the significant influence of the shell on the bubble dynamics: shell elasticity increases the resonance frequency by about 50%, and shell viscosity is responsible for about 70% of the total damping. The obtained value for shell elasticity is in quantative agreement with previously reported values. The shell viscosity increases significantly with the radius, revealing a new nonlinear behavior of the phospholipid coating.
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/1.2390673
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2007
    detail.hit.zdb_id: 1461063-2
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  • 6
    Online Resource
    Online Resource
    High-order singular value decomposition of contrast pulsing sequences for improved clutter suppression
    Acoustical Society of America (ASA) ; 2022
    In:  The Journal of the Acoustical Society of America Vol. 152, No. 4_Supplement ( 2022-10-01), p. A184-A184
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 152, No. 4_Supplement ( 2022-10-01), p. A184-A184
    Abstract: Contrast-enhanced ultrasound is a diagnostic tool used to visualize blood flow in the cardiovascular system. The use of ultrasound contrast agent (microbubbles) in combination with contrast pulsing scheme (CPS) improves the sensitivity and specificity of ultrasound flow imaging by enhancing the signal in the blood compartment. The commonly used CPS are pulse inversion (PI), amplitude modulation (AM), and amplitude-modulated pulse inversion (AMPI). Using differences in phase or amplitude of multiple pulses, the linear tissue clutter signal can be suppressed. However, this process can be degraded by motion or non-linear propagation of the ultrasound wave. These effects cause the cancellation of linear clutter signal to be ineffective We propose using higher-order singular value decomposition (HOSVD) with spatial, temporal, and pulsing dimensions as the input to improve clutter suppression under the conditions of motion and non-linear propagation. We performed systematic in-vitro- experiment emulating these conditions, as well as in-vivo cardiac measurements. The results showed that HOSVD increases the clutter suppression of all the 3 CPS compared to the conventional linear processing. The improvement of clutter reduction could be beneficial to various cardiac evaluation like myocardial perfusion or intra ventricular flow assessment.
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/10.0015970
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2022
    detail.hit.zdb_id: 1461063-2
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  • 7
    Online Resource
    Online Resource
    An iterative method to evaluate one-dimensional pulsed nonlinear elastic wavefields and mixing of elastic waves in solids
    Acoustical Society of America (ASA) ; 2022
    In:  The Journal of the Acoustical Society of America Vol. 151, No. 5 ( 2022-05-01), p. 3316-3327
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 151, No. 5 ( 2022-05-01), p. 3316-3327
    Abstract: Over the last 15 years, literature on nondestructive testing has shown that the generation of higher harmonics and nonlinear mixing of waves could be used to obtain the nonlinearity parameters of an elastic medium and thereby gather information about its state, e.g., aging and fatigue. To design ultrasound measurement setups based on these phenomena, efficient numerical modeling tools are needed. In this paper, the iterative nonlinear contrast source method for numerical modeling of nonlinear acoustic waves is extended to the one-dimensional elastic case. In particular, nonlinear mixing of two collinear bulk waves (one compressional, one shear) in a homogeneous, isotropic medium is considered, taking into account its third-order elastic constants (A,  B,  and  C). The obtained results for nonlinear propagation are in good agreement with a benchmark solution based on the modified Burgers equation. The results for the resonant waves that are caused by the one-way and two-way mixing of primary waves are in quantitative agreement with the results in the literature [Chen, Tang, Zhao, Jacobs, and Qu, J. Acoust. Soc. Am. 136(5), 2389–2404 (2014)]. The contrast source approach allows the identification of the propagating and evanescent components of the scattered wavefield in the wavenumber-frequency domain, which provides physical insight into the mixing process and explains the propagation direction of the resonant wave.
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/10.0010448
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2022
    detail.hit.zdb_id: 1461063-2
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  • 8
    Online Resource
    Online Resource
    Ultra-high-speed imaging of bubbles interacting with cells and tissue
    Acoustical Society of America (ASA) ; 2006
    In:  The Journal of the Acoustical Society of America Vol. 120, No. 5_Supplement ( 2006-11-01), p. 3229-3229
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 120, No. 5_Supplement ( 2006-11-01), p. 3229-3229
    Abstract: Ultrasound contrast microbubbles are exploited in molecular imaging, where bubbles are directed to target cells and where their high-scattering cross section to ultrasound allows for the detection of pathologies at a molecular level. In therapeutic applications vibrating bubbles close to cells may alter the permeability of cell membranes, and these systems are therefore highly interesting for drug and gene delivery applications using ultrasound. In a more extreme regime bubbles are driven through shock waves to sonoporate or kill cells through intense stresses or jets following inertial bubble collapse. Here, we elucidate some of the underlying mechanisms using the 25-Mfps camera Brandaris128, resolving the bubble dynamics and its interactions with cells. We quantify acoustic microstreaming around oscillating bubbles close to rigid walls and evaluate the shear stresses on nonadherent cells. In a study on the fluid dynamical interaction of cavitation bubbles with adherent cells, we find that the nonspherical collapse of bubbles is responsible for cell detachment. We also visualized the dynamics of vibrating microbubbles in contact with endothelial cells followed by fluorescent imaging of the transport of propidium iodide, used as a membrane integrity probe, into these cells showing a direct correlation between cell deformation and cell membrane permeability.
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/1.4788217
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2006
    detail.hit.zdb_id: 1461063-2
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  • 9
    Online Resource
    Online Resource
    Microbubble spectroscopy of microbubble-loaded stem cells for targeted cell therapy
    Acoustical Society of America (ASA) ; 2014
    In:  The Journal of the Acoustical Society of America Vol. 135, No. 4_Supplement ( 2014-04-01), p. 2310-2310
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 135, No. 4_Supplement ( 2014-04-01), p. 2310-2310
    Abstract: Stem cells can be conjugated with targeted microbubbles to form highly echogenic complexes, dubbed StemBells. The complexes can improve stem cell delivery for the local repair of damaged cardiac tissue after a myocardial infarction through propulsion by acoustic radiation forces. While the first in-vivo tests hold great promise, the system would greatly benefit from a mapping of the acoustic parameter space. Here, we develop the theoretical background based on a modified Rayleigh-Plesset type equation to describe the dynamics of the StemBells in response to ultrasound. The complex is shown to resonate as a whole entity and resonance curves are constructed from numerical simulations resembling single bubble responses at a size that relates to the effective complex radius ~10 μm. Ultra high-speed optical imaging of single StemBell complexes at different frequencies using the microbubble spectroscopy method allows for a full characterization with excellent agreement with the developed model. Moreover, from the experimental resonance curves, we obtain values for the effective viscoelastic shell parameters of the StemBell complexes. These results have enabled the demonstration of the feasibility of manipulating StemBells inside chicken embryo microvasculature in an accompanying paper.
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/1.4877613
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2014
    detail.hit.zdb_id: 1461063-2
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  • 10
    Online Resource
    Online Resource
    The stable nonlinear acoustic response of free-floating lipid-coated microbubbles
    Acoustical Society of America (ASA) ; 2014
    In:  The Journal of the Acoustical Society of America Vol. 135, No. 4_Supplement ( 2014-04-01), p. 2310-2311
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 135, No. 4_Supplement ( 2014-04-01), p. 2310-2311
    Abstract: The stability of the microbubbles maintained by the lipid coating is crucial for diagnostic contrast-enhanced ultrasound imaging. We present a study of the stability of the dynamic response of single free-floating microbubbles (DSPC-based homemade microbubbles) with an acoustical camera. A 30 MHz probing wave (800 μs duration) measures the dynamic response of single microbubbles to 42 short sine bursts (1 MHz, 10 μs duration, 3 μs interval between each excitation) at three different peak pressures (25, 100, and 200 kPa). For each microbubble exposed to the 42 consecutive pulses, the following parameters were calculated: the radial strain at the driving frequency (ɛf), at the second/third harmonic frequencies (ɛ2f,ɛ3f), the ratio of radial excursion in expansion over that in compression (EoC) and the dc offset in the time-domain response. Nearly all 1500 individual microbubbles measured showed stable vibrational response. As expected ɛ2f and ɛ3f increase with ɛf, but they reach a plateau when ɛf exceeds about 30%. For ɛf smaller than 15%, we observed compression-dominant behaviors (dc offset & lt; 0 and EoC & lt; 1), while microbubbles show expansion-dominant responses (dc offset & gt; 0 and EoC & gt; 1) for ɛf larger than 15%.
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/1.4877617
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 2014
    detail.hit.zdb_id: 1461063-2
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