In:
Cancer Science, Wiley, Vol. 104, No. 12 ( 2013-12), p. 1697-1704
Abstract:
Multiple myeloma ( MM ) is a currently incurable blood cancer. Here we tested the effects of a small compound bigelovin on MM cells, and reported that it caused cell cycle arrest and subsequently induced apoptosis. Bigelovin triggered proteolysis of E 2 F 1, which could be inhibited by caspase inhibitor. To investigate the clinical relevance, the expression of E 2 F 1 in MM specimens was tested, and the results showed that E 2 F 1 was overexpressed in 25–57% of MM patients and was associated with higher International Staging System ( ISS ) stage. These results suggest that E 2 F 1 may be important for MM pathogenesis, and bigelovin could serve as a lead compound for the development of E 2 F 1 inhibitor.
Type of Medium:
Online Resource
ISSN:
1347-9032
,
1349-7006
DOI:
10.1111/cas.2013.104.issue-12
Language:
English
Publisher:
Wiley
Publication Date:
2013
detail.hit.zdb_id:
2115647-5
detail.hit.zdb_id:
2111204-6
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