In:
Bipolar Disorders, Wiley, Vol. 16, No. 7 ( 2014-11), p. 764-768
Abstract:
Copy number variants ( CNV s) have been shown to affect susceptibility for neuropsychiatric disorders. To date, studies implicating the serotonergic system in complex conditions have just focused on single nucleotide polymorphisms ( SNP s). We therefore sought to identify novel common genetic copy number polymorphisms affecting genes of the serotonergic system, and to assess their putative role in bipolar affective disorder ( BPAD ) and major depressive disorder ( MDD ). Methods A selection of 41 genes of the serotonergic system encoding receptors, the serotonin transporter, metabolic enzymes and chaperones were investigated using a paired‐end mapping ( PEM ) approach on next‐generation sequencing data from the pilot project of the 1000 Genomes Project . For association testing, 593 patients with MDD , 1,145 patients with BPAD , and 1,738 healthy controls were included in the study. Results PEM led to the identification of a microdeletion in the gene encoding tryptophan hydroxylase 2 ( TPH 2 ), affecting an amygdala‐ and hippocampus‐specific isoform. It was not associated with BPAD or MDD using a case–control association approach. Conclusions We did not find evidence for a role of the TPH 2 microdeletion in the pathoetiology of affective disorders. Further studies examining its putative role in behavioral traits regulated by the limbic system are warranted.
Type of Medium:
Online Resource
ISSN:
1398-5647
,
1399-5618
DOI:
10.1111/bdi.2014.16.issue-7
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2001157-X
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