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  • SAGE Publications  (30)
  • 2015-2019  (30)
  • 1
    Online Resource
    Online Resource
    Metformin Prolongs Survival in Type 2 Diabetes Lung Cancer Patients With EGFR-TKIs
    SAGE Publications ; 2019
    In:  Integrative Cancer Therapies Vol. 18 ( 2019-01), p. 153473541986949-
    Details
    In: Integrative Cancer Therapies, SAGE Publications, Vol. 18 ( 2019-01), p. 153473541986949-
    Abstract: Background: Metformin use reportedly reduces cancer risk and improves survival in lung cancer patients. This study aimed to investigate the effect of metformin use in patients with diabetes mellitus (DM) and lung cancer receiving epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) therapy. Methods: A nationwide, population-based cohort study was conducted using the Taiwan National Health Insurance Research Database. From January 1, 2004, to December 31, 2012, a total of 373 metformin and 1260 non-metformin lung cancer cohorts with type 2 DM and EGFR-TKI treatment were studied. Results: Metformin use was significantly associated with a reduced risk of death (hazard ratio: 0.73, 95% confidence interval [CI]: 0.62-0.85, P 〈 .001), as well as a significantly longer median progression-free survival (9.2 months, 95% CI: 8.6-11.7, vs 6.4 months, 95% CI: 5.9-7.2 months, P 〈 .001) and median overall survival (33.4 months, 95% CI: 29.4-40.2, vs 25.4 months, 95% CI: 23.7-27.2 months, P 〈 0.001). Conclusions: In conclusion, metformin may potentially enhance the therapeutic effect and increase survival in type 2 DM patients with lung cancer receiving EGFR-TKI therapy.
    Type of Medium: Online Resource
    ISSN: 1534-7354 , 1552-695X
    URL: Article
    DOI: 10.1177/1534735419869491
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2101248-9
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  • 2
    Online Resource
    Online Resource
    Partially threaded headless screw may benefit adequate interfragmentary compression and reduced driving torque for small bone fixation
    SAGE Publications ; 2018
    In:  Journal of Orthopaedic Surgery Vol. 26, No. 1 ( 2018-01), p. 230949901876013-
    Details
    In: Journal of Orthopaedic Surgery, SAGE Publications, Vol. 26, No. 1 ( 2018-01), p. 230949901876013-
    Type of Medium: Online Resource
    ISSN: 2309-4990 , 2309-4990
    URL: Article
    DOI: 10.1177/2309499018760130
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2128854-9
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  • 3
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    Online Resource
    Functional outcomes of outpatient balance training following total knee replacement in patients with knee osteoarthritis: a randomized controlled trial
    SAGE Publications ; 2015
    In:  Clinical Rehabilitation Vol. 29, No. 9 ( 2015-09), p. 855-867
    Details
    In: Clinical Rehabilitation, SAGE Publications, Vol. 29, No. 9 ( 2015-09), p. 855-867
    Abstract: To evaluate whether balance training after total knee replacement surgery improves functional outcomes and to determine whether postoperative balance is associated with mobility. Design: A prospective intervention study and randomized controlled trial with an intention-to-treat analysis. Setting: The rehabilitation center of a university-based teaching hospital. Participants: A total of 130 patients with knee osteoarthritis who had undergone total knee replacement surgery were recruited to attend an outpatient rehabilitation program. They were randomly allocated to additional balance rehabilitation and functional rehabilitation groups. Interventions: During the eight-week outpatient rehabilitation program, both groups received general functional training. Patients in the balance rehabilitation group received an additional balance-based rehabilitation program. Primary outcome measures: The functional reach test, single-leg stance test, 10-m walk test, Timed Up and Go Test, timed chair-stand test, stair-climb test, and Western Ontario and McMaster Universities Osteoarthritis Index were measured at baseline, eight weeks (T 1 ), and 32 weeks (T 2 ). Results: The balance rehabilitation group patients demonstrated significant improvement in the results of the functional reach test at T 1 (37.6 ±7.8 cm) and T 2 (39.3 ±9.7 cm) compared with the baseline assessment (11.5 ±2.9 cm) and Timed Up and Go Test at T 1 (8.9 ±1.2 seconds) and T 2 (8.0 ±1.9 seconds) compared with the baseline assessment (12.5 ±1.8 seconds). Moreover, the balance rehabilitation group patients exhibited significantly greater improvements in balance and mobility than did the functional rehabilitation group patients (all P  〈  0.001). Furthermore, improved balance was significantly associated with improved mobility at T 2 . Conclusion: Postoperative outpatient rehabilitation with balance training improves the balance, mobility, and functional outcomes in patients with knee osteoarthritis after total knee replacement.
    Type of Medium: Online Resource
    ISSN: 0269-2155 , 1477-0873
    URL: Article
    DOI: 10.1177/0269215514564086
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2028323-4
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  • 4
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    Online Resource
    Effects of a Nurse-Led, Stage-Matched, Tailored Program for Smoking Cessation in Health Education Centers: A Prospective, Randomized, Controlled Trial
    SAGE Publications ; 2019
    In:  Clinical Nursing Research Vol. 28, No. 7 ( 2019-09), p. 812-829
    Details
    In: Clinical Nursing Research, SAGE Publications, Vol. 28, No. 7 ( 2019-09), p. 812-829
    Abstract: The purpose of this study was to examine the effectiveness of a stage-matched intervention performed at outpatient clinics. Participants were randomly assigned to an intervention group (IG) or usual care group (UCG). The trial was targeted on smoking patients with coronary heart disease or diabetes. After completing the 3-month intervention, both groups received a telephone follow-up at 6 months. This analysis showed that the outcomes of the IG for the 7-day point prevalence (PP) of abstinence (odds ratio [OR] = 2.00; p = .001) and 30-day PP (OR = 2.27; p = .004) at 6 months were significantly better than the UCG. Stage of change (OR = 4.06; p 〈 .001) and decreased daily cigarette consumption by 50% at 6 months (OR = 2.26; p = .019) outcomes also improved significantly. The preliminary results showed that a nurse-led cessation intervention in clinics may be an effective approach to help outpatients quit smoking.
    Type of Medium: Online Resource
    ISSN: 1054-7738 , 1552-3799
    URL: Article
    DOI: 10.1177/1054773817754276
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2034682-7
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  • 5
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    Online Resource
    Paclitaxel, oxaliplatin, 5-fluorouracil and leucovorin combination chemotherapy in patients with recurrent or metastatic gastric cancer
    SAGE Publications ; 2018
    In:  Tumori Journal Vol. 104, No. 1 ( 2018-01), p. 22-29
    Details
    In: Tumori Journal, SAGE Publications, Vol. 104, No. 1 ( 2018-01), p. 22-29
    Abstract: This study evaluated the efficacy and toxicity of combination chemotherapy with paclitaxel, oxaliplatin, 5-fluorouracil and leucovorin (POFL) in patients with recurrent or metastatic gastric cancer. Methods: One hundred and thirty-eight patients with histologically confirmed recurrent or metastatic gastric adenocarcinoma were treated with the POFL regimen: paclitaxel at a dose of 135 mg/m 2 as a 3-hour intravenous infusion on day 1, oxaliplatin 85 mg/m 2 and leucovorin 400 mg/m 2 as an intravenous infusion over 2 hours on day 1, followed by 5-fluorouracil 2,400 mg/m 2 as an infusion over a 46-hour period on 3 consecutive days, in a 2-week cycle. Results: Twelve patients could not be evaluated for response because of the absence of any measurable lesions or early discontinuation of therapy, so responses were assessed in 126 patients. The overall objective response rate was 56.3% (95% CI, 47.5%-64.9%). The median time to progression was 6.7 months (95% CI, 5.8-7.6 months), and the median overall survival was 12.6 months (95% CI, 11.3-13.9 months). The most common grade 3 and 4 toxicities were neutropenia (50.7%), peripheral neurotoxicity (16.7%) and alopecia (27.5%). Conclusions: Combination chemotherapy with POFL offers a new, active and safe approach to the treatment of recurrent or metastatic gastric cancer.
    Type of Medium: Online Resource
    ISSN: 0300-8916 , 2038-2529
    URL: Article
    DOI: 10.5301/tj.5000665
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 280962-X
    detail.hit.zdb_id: 2267832-3
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  • 6
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    Online Resource
    Clustering of Several Typical Behavioral Characteristics of Commercial Vehicle Drivers Based on GPS Data Mining: Case Study of Highways in China
    SAGE Publications ; 2016
    In:  Transportation Research Record: Journal of the Transportation Research Board Vol. 2581, No. 1 ( 2016-01), p. 154-163
    Details
    In: Transportation Research Record: Journal of the Transportation Research Board, SAGE Publications, Vol. 2581, No. 1 ( 2016-01), p. 154-163
    Abstract: Some studies of driving behavior have been based on data mining to create a mechanism that relates data derived from vehicle monitoring, driver behavioral characteristics, and road safety to each other. To make the best of GPS data collected by transportation businesses and explore the potential rules of commercial vehicle driver behavioral characteristics, the parameters related to driving behavioral characteristics are extracted according to GPS data attributes based on factor analysis, and eight parameters of driving behavioral characteristics are transformed into a few aggregated variables containing clear information about driving behavior. With these variables as indicators, a cluster analysis of commercial vehicle driver behavioral characteristics in the selected case is carried out through hierarchical clustering. The results show that commercial vehicle driver behavioral characteristics can be effectively aggregated into four kinds: acceleration–deceleration, speeding-prone, acceleration, and deceleration. Of the four kinds, drivers with relatively serious acceleration–deceleration behavior are also characterized by three other relatively serious behaviors; such drivers have relatively high driving risks, so transportation businesses need to focus their supervision on those drivers. The research results have some relevance to the supervision and training of commercial vehicle drivers in China.
    Type of Medium: Online Resource
    ISSN: 0361-1981 , 2169-4052
    URL: Article
    DOI: 10.3141/2581-18
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2403378-9
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  • 7
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    Online Resource
    Risk Factors and Coping Style Affect Health Outcomes in Adults With Type 2 Diabetes
    SAGE Publications ; 2016
    In:  Biological Research For Nursing Vol. 18, No. 1 ( 2016-01), p. 82-89
    Details
    In: Biological Research For Nursing, SAGE Publications, Vol. 18, No. 1 ( 2016-01), p. 82-89
    Abstract: Most psychosocial interventions among individuals with Type 2 diabetes mellitus (T2DM) target depressive symptoms (DSs) rather than causal antecedents that lead to DSs or affect health-related quality of life (HrQoL). This research investigated a conceptual model of the effects of risk factors and coping styles on HrQoL and DSs in patients with T2DM. Method: A descriptive, correlational design was used with a convenience sample of 241 adults with T2DM aged ≥ 20 years recruited from a hospital metabolic outpatient department. Data were collected using a demographic questionnaire, the modified Ways of Coping Checklist, the Center for Epidemiological Studies Depression Scale, the Short Form 36 Health Survey, and physiological examination. HbA 1 C was collected from participants’ medical records. Structural equation modeling techniques were used to analyze relationships among risk factors, mediators, and HrQoL. Results: Younger age, more education, and longer duration of diabetes predicted better physical quality of life. Duration of diabetes and three coping styles predicted DSs. Longer duration of diabetes and lower fasting glucose predicted better mental quality of life. Three coping styles acted as mediators between risk factors and health, that is, active and minimizing styles promoted positive outcomes, while avoidance promoted negative outcomes. Conclusions: This integrated model provides a holistic picture of how risk factors and coping style influence HrQoL and DSs in individuals with T2DM. Nurses could use active coping strategies in cognitive behavioral therapy to enhance glycemic control in patients with T2DM.
    Type of Medium: Online Resource
    ISSN: 1099-8004 , 1552-4175
    URL: Article
    DOI: 10.1177/1099800415569845
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2070503-7
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  • 8
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    Online Resource
    Hypoxia Regulates the Therapeutic Potential of Mesenchymal Stem Cells Through Enhanced Autophagy
    SAGE Publications ; 2015
    In:  The International Journal of Lower Extremity Wounds Vol. 14, No. 1 ( 2015-03), p. 63-72
    Details
    In: The International Journal of Lower Extremity Wounds, SAGE Publications, Vol. 14, No. 1 ( 2015-03), p. 63-72
    Abstract: Bone marrow–derived mesenchymal stem cells (BM-MSCs)have great therapeutic potential for the repair of diabetic lower-limb ischemia because of their proangiogenic properties. However, cells transplanted into an ischemic environment have reduced cell survival rates and impaired angiogenic capacity in vivo. We explored hypoxia pretreatment as a method to promote BM-MSC survival by inducing autophagy. Our results showed that hypoxic pretreatment has no effect on the phenotype or differentiation capacity of BM-MSCs; however, hypoxia increased viability and reduced apoptosis in cells treated with lipopolysaccharide. Immunofluorescence and western blot results showed that hypoxia pretreatment enhances cell autophagy mediated by elevated expression of hypoxia inducible factor-1α (HIF-1α). The AMPK/mTOR (adenosine monophosphate–activated protein kinase/mammalian target of rapamycin) signaling pathway was also activated in BM-MSCs during hypoxia-enhanced autophagy. It is important to note that hypoxia pretreatment in BM-MSCs significantly enhanced cell survival and promoted angiogenesis in the lower limb of ischemic diabetic rats. In conclusion, hypoxia pretreatment enhances survival in BM-MSCs, promoting angiogenesis by increasing autophagy and significantly decreasing apoptosis. Therefore, modulation of autophagy with hypoxic pretreatment may provide a novel strategy to improve MSC-based therapies.
    Type of Medium: Online Resource
    ISSN: 1534-7346 , 1552-6941
    URL: Article
    DOI: 10.1177/1534734615573660
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2135166-1
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  • 9
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    Online Resource
    Design and Simulation Analysis of Lightweight HDPE Milk Bottle
    SAGE Publications ; 2018
    In:  Polymers and Polymer Composites Vol. 26, No. 1 ( 2018-01), p. 91-98
    Details
    In: Polymers and Polymer Composites, SAGE Publications, Vol. 26, No. 1 ( 2018-01), p. 91-98
    Abstract: A lightweight design is proposed for a 2800 ml HDPE milk bottle. In designing the bottle, a three-dimensional elastic-plastic dynamic finite element model is first constructed to explore the effect of the bottle thickness on the critical load and stress distribution. The validity of the proposed model is confirmed by comparing the numerical results for the load-displacement response of the bottle with the experimental results. A parametric analysis is then performed to examine the effects of the body thickness and bottom thickness on the critical load and weight of the HDPE bottle. The results show that the critical load increases with an increasing body thickness, but is insensitive to the bottom thickness. Finally, a lightweight design is proposed in which the structural shape of the original bottle is retained, but the thickness is varied in different regions of the body in order to reduce the weight. It is shown that the redesigned bottle achieves the same maximum top-load 315 N, but reduces the weight by 21.4% compared to the reference design obtained in the parametric analysis.
    Type of Medium: Online Resource
    ISSN: 0967-3911 , 1478-2391
    URL: Article
    DOI: 10.1177/096739111802600111
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2099644-5
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  • 10
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    Online Resource
    New fluorinated aromatic polyamides based on N , N -bis(4-carboxyphenyl)-4-trifluoromethylaniline
    SAGE Publications ; 2019
    In:  High Performance Polymers Vol. 31, No. 6 ( 2019-08), p. 613-622
    Details
    In: High Performance Polymers, SAGE Publications, Vol. 31, No. 6 ( 2019-08), p. 613-622
    Abstract: A new aromatic diacid monomer, N, N-bis(4-carboxyphenyl)-4-trifluoromethylaniline, was synthesized by the substitution reaction of 4-trifluoromethylaniline with 4-fluorobenzonitrile, followed by alkaline hydrolysis of the dinitrile intermediate. Several polyamides with 4-trifluoromethyltriphenylamine moieties were prepared from the diacid and various aromatic diamines via the direct phosphorylation polycondensation. All the polyamides were amorphous and readily soluble in many polar organic solvents such as N, N-dimethylacetamide and N-methyl-2-pyrrolidone, and could be solution-cast into transparent, tough, and flexible films with good mechanical properties. They exhibited good thermal stability with glass transition temperatures of 260–330°C, 10% weight-loss temperatures above 500°C, and char yields higher than 60% at 800°C in nitrogen. These polymers had low dielectric constants of 3.35–3.72 (100 Hz), low water uptake of 1.80–2.60%, and high transparency with an ultraviolet–visible absorption cutoff wavelength in the range of 378–390 nm. Cyclic voltammograms of the polyamide films cast onto an indium-tin oxide–coated glass substrate exhibited a reversible oxidation redox coupled with oxidation half-wave potentials ( E 1/2 ) of 0.95–1.04 V versus silver/silver chloride in an acetonitrile solution.
    Type of Medium: Online Resource
    ISSN: 0954-0083 , 1361-6412
    URL: Article
    DOI: 10.1177/0954008318774926
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 1483713-4
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