In:
Chemistry – A European Journal, Wiley, Vol. 24, No. 34 ( 2018-06-18), p. 8609-8614
Abstract:
Four so far unknown pyrroloquinoline alkaloids, yellow mycenaflavins A, B, and C, and the purple mycenaflavin D, have been isolated from the fruiting bodies of Mycena haematopus . The structures of these new alkaloids were elucidated by NMR spectroscopy and HRMS (ESI + ). The mycenaflavins are structurally related to mycenarubins and haematopodins, which have been previously identified in M. haematopus . However, compared with other known fungal pyrroloquinoline alkaloids, the mycenaflavins contain an additional double bond within the pyrroloquinoline moiety that accounts for the yellow colour of the monomeric mycenaflavins A, B, and C. The purple mycenaflavin D is the first known dimeric pyrroloquinoline alkaloid with a C−C bridge between the two pyrroloquinoline units. Although the minor pyrroloquinoline alkaloid constituent mycenaflavin A exhibits only moderate bioactivity against the soil bacterium Azoarcus tolulyticus , the major pyrroloquinoline alkaloid constituent haematopodin B is similarly active as the antibiotic gentamicin.
Type of Medium:
Online Resource
ISSN:
0947-6539
,
1521-3765
DOI:
10.1002/chem.201800235
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
1478547-X
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