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  • SAGE Publications  (14)
  • 2010-2014  (14)
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  • SAGE Publications  (14)
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  • 2010-2014  (14)
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  • 1
    Online Resource
    Online Resource
    A novel combination of nano-scaffolds with micro-scaffolds to mimic extracellularmatrices improve osteogenesis
    SAGE Publications ; 2014
    In:  Journal of Biomaterials Applications Vol. 29, No. 1 ( 2014-07), p. 59-71
    Details
    In: Journal of Biomaterials Applications, SAGE Publications, Vol. 29, No. 1 ( 2014-07), p. 59-71
    Abstract: To improve bone engineering for clinical applications, we coupled nanofiber-peptide hydrogel to nano-hydroxyapatite/collagen to form a bioactive scaffold (cnHAC) that mimics extracellular matrices. In comparison to nano-hydroxyapatite/collagen, we found that cnHAC promoted cell adhesion and spreading, and DNA content measurements, alkaline phosphatase activity assays, and reverse transcriptase-polymerase chain reaction analyses of osteogenic gene expression showed that cnHAC significantly improved cellular attachment, proliferation, and osteogenic differentiation in vitro ( P  〈  0.05). In vivo models based on rat calvarial implants showed that cnHAC significantly enhanced bone regeneration ( P  〈  0.05). In conclusion, we demonstrated that novel cnHAC scaffolds could potentially facilitate future bone regenerative medicine.
    Type of Medium: Online Resource
    ISSN: 0885-3282 , 1530-8022
    URL: Article
    DOI: 10.1177/0885328213514467
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2072559-0
    SSG: 12
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  • 2
    Online Resource
    Online Resource
    New Cembranoid Diterpene from the South China Sea Soft Coral Sarcophyton sp
    SAGE Publications ; 2013
    In:  Natural Product Communications Vol. 8, No. 12 ( 2013-12), p. 1934578X1300801-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 8, No. 12 ( 2013-12), p. 1934578X1300801-
    Abstract: One new oxygenated cembranoid diterpene, named sarcophytol W (1), along with six known analogues (2–7) were isolated from a soft coral Sarcophyton sp. collected from the South China Sea. Their structures were elucidated by spectroscopic analyses and by comparison with previously reported data. The absolute configuration of 1 was assigned on the basis of the absolute configuration of the related congener 2, which was determined by application of the modified Mosher's method. All the compounds were evaluated for their antibacterial and antifouling activities.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X1300801204
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2430442-6
    SSG: 15,3
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  • 3
    Online Resource
    Online Resource
    Prevalence and control of dyslipidaemia among diabetic patients with microalbuminuria in a Chinese hospital
    SAGE Publications ; 2013
    In:  Diabetes and Vascular Disease Research Vol. 10, No. 2 ( 2013-03), p. 169-178
    Details
    In: Diabetes and Vascular Disease Research, SAGE Publications, Vol. 10, No. 2 ( 2013-03), p. 169-178
    Abstract: Accumulating evidence indicates that dyslipidaemia plays an important role in the progression of kidney disease in patients with diabetes. Hyperlipidaemia is a risk factor for microalbuminuria in patients with diabetes. Little information exists on the prevalence and control of dyslipidaemia among diabetic patients with microalbuminuria in China. The aims of this study were to investigate the prevalence and control of dyslipidaemia among diabetic patients with microalbuminuria in a Chinese hospital as well as factors affecting the disease. Methods: A total of 1060 type 2 diabetic inpatients were assigned to the with-microalbuminuria group ( n = 635) or the without-microalbuminuria group on the basis of urinary albumin-to-creatinine ratios (UACRs = 30–299 mg/g). Serum levels and the control of lipid profiles were assessed and classified according to the 2011 American Diabetes Association (ADA) guidelines, and low-density lipoprotein–cholesterol (LDL-C) was also assessed and classified according to Chinese intensified control criteria. Multiple regression analyses were performed to examine the factors affecting lipid variables. Results: Among patients with microalbuminuria, a significantly lower prevalence was found (33.1% vs. 58.6%; 35.3% vs. 52.5%, all p 〈 0.001) at target levels [LDL-C 〈 2.60 mmol/L or high-density lipoprotein–cholesterol (HDL-C) 〉 1.0 mmol/L for men and 〉 1.3 mmol/L for women]. According to the intensified LDL-C goal ( 〈 2.07 mmol/L), a lower prevalence was found in male patients (15.5% vs. 32.7%, p 〈 0.001). Fewer patients with microalbuminuria were adherent to the therapy prescribed for dyslipidaemia (28.8% vs. 43.3%, p 〈 0.001). Even among patients who were on lipid-lowering treatment, the majority of individuals remained uncontrolled for all three lipid fractions [LDL-C, HDL-C and triglyceride (TG)] (82.5% vs. 69.0%, p = 0.003). Lipid and lipoprotein parameters were associated with gender and age. Conclusion: In China, diabetic patients with microalbuminuria displayed typical dyslipidaemias and were not adequately controlled. Intensified LDL-C and overall lipid-lowering clinical goals are potential precautions taken against diabetic nephropathy.
    Type of Medium: Online Resource
    ISSN: 1479-1641 , 1752-8984
    URL: Article
    DOI: 10.1177/1479164112454756
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2250797-8
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  • 4
    Online Resource
    Online Resource
    Histone acetylation and expression of mono-aminergic transmitters synthetases involved in CUS-induced depressive rats
    SAGE Publications ; 2014
    In:  Experimental Biology and Medicine Vol. 239, No. 3 ( 2014-03), p. 330-336
    Details
    In: Experimental Biology and Medicine, SAGE Publications, Vol. 239, No. 3 ( 2014-03), p. 330-336
    Abstract: Histone acetylation has been linked to depression, the etiology of which involves many factors such as genetics, environments, and epigenetics. The aim of the present study was to investigate whether it was associated with epigenetic histone modification and gene expression of enzymes responsible for the biosynthesis of norepinephrine and serotonin in rat depression model induced by chronic unpredictable stress (CUS). Eight-week-old male Sprague-Dawley rats were exposed to CUS over 28 days. It was shown that the CUS-induced rats displayed remarked anxiety- and depression-like behavior with weakened locomotor activity in open field test and prolonged immobility in forced swimming test. Western blot revealed that CUS led to significant decrease in acetylation of H3 at Lysine 9 (K9) and H4 at Lysine 12 (K12) with obviously increasing histone deacetylases 5 (HDAC5) expression in hippocampus of CUS-induced rats. Meanwhile, there was an obviously decreased expression of tyrosine hydroxylase (TH) and tryptophan hydroxylase (TPH) both at protein and mRNA levels. Administration of sodium valproate (VPA), a histone deacetylase 5 (HDAC5) inhibitor, not only significantly relieved the anxiety- and depression-like behaviors of CUS-induced rats but also clearly blunted decrease of H3(K9) and H4(K12) acetylation and expression of TH and TPH, and prevented increase of HDAC5 expression. The results indicate that there exists possible interrelation between TH and TPH gene expression and epigenetic histone acetylation in CUS-induced depressive rats, which at least partly contributes to the etiology of depression.
    Type of Medium: Online Resource
    ISSN: 1535-3702 , 1535-3699
    URL: Article
    DOI: 10.1177/1535370213513987
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2020856-X
    SSG: 12
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  • 5
    Online Resource
    Online Resource
    Biodegradable poly(butylene-carbonate) porous membranes for guided bone regeneration: In vitro and in vivo studies
    SAGE Publications ; 2013
    In:  Journal of Bioactive and Compatible Polymers Vol. 28, No. 6 ( 2013-11), p. 621-636
    Details
    In: Journal of Bioactive and Compatible Polymers, SAGE Publications, Vol. 28, No. 6 ( 2013-11), p. 621-636
    Abstract: Poly(butylene-carbonate) is a potential alternative to poly(ε-caprolactone) for biomedical application. Although mechanical properties of porous poly(butylene-carbonate) membranes were inferior to poly(ε-caprolactone), its contact angles (47.41° ± 1.17°) were lower than poly(ε-caprolactone) (77.24° ± 0.54°) (p 〈 0.001). It degraded faster than poly(ε-caprolactone) during a 10-week in vitro experiment (p 〈 0.01). Moreover, it had excellent bioactivity during simulated body fluid immersion. Cell spreading on poly(butylene-carbonate) was better than that on poly(ε-caprolactone). Cell behavior tests including cytotoxicity, proliferation, and differentiation were performed. The poly(butylene-carbonate) is more compatible with cells and promotes cell differentiation. In vivo, the defects covered by poly(butylene-carbonate) and poly(ε-caprolactone) membranes had a similar degree of regeneration at 4 weeks. It was concluded that poly(butylene-carbonate) could potentially be used to guide bone regeneration, and it is a potential new biodegradable polymer.
    Type of Medium: Online Resource
    ISSN: 0883-9115 , 1530-8030
    URL: Article
    DOI: 10.1177/0883911513509471
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2073790-7
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  • 6
    Online Resource
    Online Resource
    Wireless Communication Simulation Model for Traffic Monitoring Systems Based on Dynamic Cellular Handoffs : Framework and Evaluation
    SAGE Publications ; 2012
    In:  Transportation Research Record: Journal of the Transportation Research Board Vol. 2291, No. 1 ( 2012-01), p. 26-34
    Details
    In: Transportation Research Record: Journal of the Transportation Research Board, SAGE Publications, Vol. 2291, No. 1 ( 2012-01), p. 26-34
    Abstract: Technology for tracking with handoff-based cellular probes is one of the most important modern methods of traffic monitoring. Some simulation frameworks have been proposed to investigate the key issues in such systems. However, most existing simulation approaches rely on assumptions of cell boundaries and handoff points; these assumptions may lead to inaccurate predictions of the performance of real systems. The proposed model incorporated the actual communication mechanism for cell phone signals used in real-world cellular networks. In the proposed simulation framework, cell boundaries were dynamic, cell sizes varied, and the handoff process was controlled by actual protocols for cellular communication. An algorithm for handoff pattern matching is also presented. The algorithm deals with the dynamic handoff sequence for the purposes of traffic detection. The approach was verified with a calibrated simulation road network. The impacts of two important factors, call duration and probe penetration, were also investigated. The results showed that the proposed simulation platform for wireless communication could produce more reliable results and gain deeper insights into the performance of the handoff-based cellular traffic monitoring systems than had been achieved through the traditional simulation approaches.
    Type of Medium: Online Resource
    ISSN: 0361-1981 , 2169-4052
    URL: Article
    DOI: 10.3141/2291-04
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2403378-9
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  • 7
    Online Resource
    Online Resource
    Predictive value of procalcitonin for excluding bloodstream infection: Results of a retrospective study and utility of a rapid, quantitative test for procalcitonin
    SAGE Publications ; 2013
    In:  Journal of International Medical Research Vol. 41, No. 5 ( 2013-10), p. 1671-1681
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 41, No. 5 ( 2013-10), p. 1671-1681
    Abstract: To assess retrospectively the diagnostic value of procalcitonin (PCT) in excluding suspected bloodstream infection, establish cut-off values for PCT levels, and compare PCT with other clinical markers. Methods The predictive accuracy of different continuous parameters was estimated by univariate analysis of the area under the receiver operating characteristic curve. Optimized cut-off points for the parameters were selected according to the maximum Youden index values, which in turn were used to define positive and negative predictive values of different parameters in diagnosing bloodstream infection. Results The PCT level yielded a statistically significant area under the receiver operating characteristic curve of 0.765, with a best cut-off value of 0.80 ng/ml (83% sensitivity; 65% specificity, Youden index, J = 0.48). Positive and negative predictive values at this cut-off value were 38% and 94%, respectively. Mann–Whitney U-test revealed significantly higher values for PCT, C-reactive protein and percentage of neutrophils, but not for white blood cell count, in patients with bloodstream infection. Conclusions The serum PCT level can potentially be used as surrogate marker to exclude bacteraemia and to inform critical management decisions regarding antibiotic usage, in patients admitted with suspected bloodstream infection.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/0300060513497558
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2082422-1
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  • 8
    Online Resource
    Online Resource
    Electrospun poly(butylene carbonate) membranes for guided bone regeneration: In vitro and in vivo studies
    SAGE Publications ; 2014
    In:  Journal of Bioactive and Compatible Polymers Vol. 29, No. 5 ( 2014-09), p. 486-499
    Details
    In: Journal of Bioactive and Compatible Polymers, SAGE Publications, Vol. 29, No. 5 ( 2014-09), p. 486-499
    Abstract: A nonwoven membrane for guided bone regeneration, constituting of poly(butylene carbonate), with a backbone that is similar to poly(ϵ-caprolactone), was prepared by electrospinning. The as-fabricated poly(butylene carbonate) membranes were to be used as guided bone regeneration membranes with efficacies equal to or better than poly(ϵ-caprolactone) membranes. The contact angles of electrospun poly(butylene carbonate) membranes (fPBC) (101.90 ± 4.19°) were lower than those for electrospun poly(ϵ-caprolactone) membranes (fPCL) (117.79 ± 3.38°) ( p  〈  0.01). To examine the biocompatibility, we investigated cell morphology, proliferation, and differentiation in vitro. The bone regenerative efficacy was evaluated in rat calvarial defect. The cell numbers were increased in accordance with culture period. Cells had a stellate shape and broad cytoplasmic extensions on the membrane. Alkaline phosphatase activity was significantly higher on fPBC than on fPCL ( p  〈  0.05). Defects covered by fPBC and fPCL achieved a similar degree of regeneration at 4 weeks in vivo and were significantly better than uncovered samples ( p  〈  0.01).Based on the results of this study, the potential for using electrospun poly(butylene carbonate) membranes in guided bone regeneration is highly significant . In addition, poly(butylene carbonate) could be a promising alternative to poly(ϵ-caprolactone) for biomedical applications.
    Type of Medium: Online Resource
    ISSN: 0883-9115 , 1530-8030
    URL: Article
    DOI: 10.1177/0883911514543055
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2073790-7
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  • 9
    Online Resource
    Online Resource
    Orally Administered Dendrobium Officinale and its Polysaccharides Enhance Immune Functions in BALB/c Mice
    SAGE Publications ; 2011
    In:  Natural Product Communications Vol. 6, No. 6 ( 2011-06), p. 1934578X1100600-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 6, No. 6 ( 2011-06), p. 1934578X1100600-
    Abstract: The immunoactivity was evaluated of Dendrobium officinale Kimura & Migo, a Chinese herbal plant, and its crude polysaccharides. Different dosages of D. officinale and its polysaccharides were orally administered to healthy BALB/c mice. The control group was given distilled water. After 4 weeks, immune parameters, including cellular immunity (delayed-type hypersensitivity and natural killer cell activity), humoral immunity (serum hemolytic complement activity), nonspecific immunity (peritoneal macrophage phagocytosis) and interferon-γ production by splenocytes were measured. The results showed that D. officinale and its polysaccharides can significantly enhance cellular immunity and nonspecific immunity in mice. Humoral immunity was also enhanced after oral administration of D. officinale, but the polysaccharides had no influence. Both D. officinale and its polysaccharides markedly increased IFN-γ production by murine splenocytes. Six fractions were isolated from the polysaccharides; the molecular weight of the major fraction was 533,700 Da, and composed of mannose, glucose and rhamnose in a molar ratio of 7.3:1.3:1.0.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X1100600627
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2011
    detail.hit.zdb_id: 2430442-6
    SSG: 15,3
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  • 10
    Online Resource
    Online Resource
    Ternary Liquid-Liquid Equilibria Measurement for Epoxidized Soybean Oil + Acetic Acid + Water
    SAGE Publications ; 2012
    In:  Natural Product Communications Vol. 7, No. 1 ( 2012-01), p. 1934578X1200700-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 7, No. 1 ( 2012-01), p. 1934578X1200700-
    Abstract: Liquid-liquid equilibria (LLE) data were measured for ternary system epoxidized soybean oil (ESO) + acetic acid + water at 313.15, 323.15 and 333.15 K, respectively. The consistency of the measured LLE data was tested, using Othmer-Tobias correlation and root-mean-square deviation (δ) in mass fraction of water in the lower phase and average value of the absolute difference ( AAD) between experimental mass fraction of epoxidized soybean oil in the upper phase and that calculated using Othmer-Tobias correlation.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X1200700126
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2430442-6
    SSG: 15,3
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