In:
Journal of Cancer Research Updates, Neoplasia Research, Vol. 3, No. 3 ( 2014-07-29)
Abstract:
Background: We analyzed the pattern of distant metastasis (DM) and secondary primary cancers (SPC) in patients with oropharyngeal squamous cell carcinoma (OPSCC) to develop surveillance guidelines. Methods: A retrospective review of 177 patients with OPSCC treated with intensity modulated radiation therapy ± chemotherapy between 2002 and 2012 was performed to characterize the rate, pattern, and timing of DM and SPC. Results: Sixteen patients (9.0%) developed DM and 9 patients (5.1%) developed a SPC. Overall, 24/177 patients (13.6%) developed a DM and/or SPC for a total of 27 events. 92.6% (25/27) of events were detectable on physical exam and/or chest CT. p16+ patients developed DM later than p16- tumors (23.4 months versus 8.7 months). Conclusions: Chest CT with physical examination detects the majority of DM and SPC in patients with OPSCC and would provide effective surveillance in these patients. A risk adapted surveillance strategy is proposed.
Type of Medium:
Online Resource
ISSN:
1929-2279
DOI:
10.6000/1929-2279.2014.03.03.5
Language:
Unknown
Publisher:
Neoplasia Research
Publication Date:
2014
detail.hit.zdb_id:
2810590-4
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