Format:
Online-Ressource (1 online resource (292 p.))
,
digital, PDF file(s).
Edition:
Online-Ausg.
ISBN:
9780511626593
Content:
The analysis of protein-protein interactions is fundamental to the understanding of cellular organization, processes, and functions. Proteins seldom act as single isolated species; rather, proteins involved in the same cellular processes often interact with each other. Functions of uncharacterized proteins can be predicted through comparison with the interactions of similar known proteins. Recent large-scale investigations of protein-protein interactions using such techniques as two-hybrid systems, mass spectrometry, and protein microarrays have enriched the available protein interaction data and facilitated the construction of integrated protein-protein interaction networks. The resulting large volume of protein-protein interaction data has posed a challenge to experimental investigation. This book provides a comprehensive understanding of the computational methods available for the analysis of protein-protein interaction networks. It offers an in-depth survey of a range of approaches, including statistical, topological, data-mining, and ontology-based methods. The author discusses the fundamental principles underlying each of these approaches and their respective benefits and drawbacks, and she offers suggestions for future research
Content:
Experimental approaches to generation of PPI data -- Computational methods for the prediction of PPIs -- Basic properties and measurements of protein interaction networks -- Modularity analysis of protein interaction networks -- Topological analysis of protein interaction networks / with Woo-chang Hwang -- Distance-based modularity analysis -- Graph-theoretic approaches to modularity analysis -- Flow-based analysis of protein interaction networks -- Statistics and machine learning based analysis of protein interaction networks / with Pritam Chanda and Lei Shi -- Integration of GO into the analysis of protein interaction networks / with Young-rae Cho -- Data fusion in the analysis of protein interaction networks
Note:
Title from publisher's bibliographic system (viewed on 05 Oct 2015)
Additional Edition:
ISBN 9780521888950
Additional Edition:
Druckausg. Zhang, Aidong Protein interaction networks Cambridge [u.a.] : Cambridge Univ. Press, 2009 ISBN 0521888956
Additional Edition:
ISBN 9780521888950
Additional Edition:
Print version ISBN 9780521888950
Language:
English
Subjects:
Biology
Keywords:
Protein-Protein-Wechselwirkung
;
Bioinformatik
DOI:
10.1017/CBO9780511626593
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