In:
Journal of Medical Primatology, Wiley, Vol. 37, No. s2 ( 2008-12), p. 62-68
Abstract:
Background Previously, we examined the effects of in vivo CTLA‐4 blockade using a fully human monoclonal antibody as a part of a DNA vaccination regimen in cynomolgus macaques ( Macaca fascicularis ). We observed that while the antibody had little effect on the IFN‐γ ELISpot response, CTLA‐4 blockade enhanced antigen‐specific cellular proliferation in both CD4 + and CD8 + T‐cell compartments. Methods We examine the specific effects of CTLA‐4 blockade on memory T‐cell compartments following the third immunization and 10 months following a fourth immunization, during the memory phase of the immune response. Results CLTA‐4 blockade enhanced CD4 + and CD8 + central memory (CD28 hi , CD95 hi ) T‐cell responses as well as a short‐lived CD8 + effector (CD28 lo , CD95 hi ) T‐cell response. Conclusions These data suggest differing effects of CTLA‐4 blockade on CD4 + and CD8 + T cells with implications on the clinical use of anti‐CTLA‐4 antibodies for enhancement of vaccine strategies or treatment of human disease.
Type of Medium:
Online Resource
ISSN:
0047-2565
,
1600-0684
DOI:
10.1111/jmp.2008.37.issue-s2
DOI:
10.1111/j.1600-0684.2008.00324.x
Language:
English
Publisher:
Wiley
Publication Date:
2008
detail.hit.zdb_id:
2026219-X
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