In:
Arteriosclerosis, Thrombosis, and Vascular Biology, Ovid Technologies (Wolters Kluwer Health), Vol. 29, No. 8 ( 2009-08), p. 1228-1234
Abstract:
We report increased levels of Dickkopf-1, a regulatory molecule of the wingless pathway, in experimental and clinical atherosclerosis, both systemically and within the plaques. Both endothelial- and platelet-derived Dickkopf-1 enhanced the inflammatory interaction between platelets and endothelial cells, potentially representing a self-perpetuating pathogenic mechanism in atherogenesis and plaque destabilization.
Type of Medium:
Online Resource
ISSN:
1079-5642
,
1524-4636
DOI:
10.1161/ATVBAHA.109.189761
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2009
detail.hit.zdb_id:
1494427-3
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