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  • 1
    Online Resource
    Online Resource
    Genome-Wide Association Studies for Albuminuria of Nondiabetic Taiwanese Population
    S. Karger AG ; 2023
    In:  American Journal of Nephrology
    Details
    In: American Journal of Nephrology, S. Karger AG
    Abstract: 〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 Chronic kidney disease, which is defined by a reduced estimated glomerular filtration rate and albuminuria, imposes a large health burden worldwide. Ethnicity-specific associations are frequently observed in genome-wide association studies (GWAS). This study conducts a GWAS of albuminuria in the nondiabetic population of Taiwan. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Nondiabetic individuals aged 30–70 years without a history of cancer were enrolled from the Taiwan Biobank. A total of 6,768 subjects were subjected to a spot urine examination. After quality control using PLINK and imputation using SHAPEIT and IMPUTE2, a total of 3,638,350 single-nucleotide polymorphisms (SNPs) remained for testing. SNPs with a minor allele frequency of less than 0.1% were excluded. Linear regression was used to determine the relationship between SNPs and log urine albumin-to-creatinine ratio. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Six suggestive loci are identified in or near the 〈 i 〉 FCRL3 〈 /i 〉 ( 〈 i 〉 p 〈 /i 〉 = 2.56 × 10 〈 sup 〉 −6 〈 /sup 〉 ), 〈 i 〉 TMEM161 〈 /i 〉 ( 〈 i 〉 p 〈 /i 〉 = 4.43 × 10 〈 sup 〉 −6 〈 /sup 〉 ), 〈 i 〉 EFCAB1 〈 /i 〉 ( 〈 i 〉 p 〈 /i 〉 = 2.03 × 10 〈 sup 〉 −6 〈 /sup 〉 ), 〈 i 〉 ELMOD1 〈 /i 〉 ( 〈 i 〉 p 〈 /i 〉 = 2.97 × 10 〈 sup 〉 −6 〈 /sup 〉 ), 〈 i 〉 RYR3 〈 /i 〉 ( 〈 i 〉 p 〈 /i 〉 = 1.34 × 10 〈 sup 〉 −6 〈 /sup 〉 ), and 〈 i 〉 PIEZO2 〈 /i 〉 ( 〈 i 〉 p 〈 /i 〉 = 2.19 × 10 〈 sup 〉 −7 〈 /sup 〉 ). Genetic variants in the 〈 i 〉 FCRL3 〈 /i 〉 gene that encode a secretory IgA receptor are found to be associated with IgA nephropathy, which can manifest as proteinuria. The 〈 i 〉 PIEZO2 〈 /i 〉 gene encodes a sensor for mechanical forces in mesangial cells and renin-producing cells. Five SNPs with a 〈 i 〉 p 〈 /i 〉 -value between 5 × 10 〈 sup 〉 −6 〈 /sup 〉 and 5 × 10 〈 sup 〉 −5 〈 /sup 〉 are also identified in five genes that may have a biological role in the development of albuminuria. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Five new loci and one known suggestive locus for albuminuria are identified in the nondiabetic Taiwanese population.
    Type of Medium: Online Resource
    ISSN: 0250-8095 , 1421-9670
    URL: Article
    DOI: 10.1159/000531783
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2023
    detail.hit.zdb_id: 1468523-1
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  • 2
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    Online Resource
    β-Catenin〈b〉〈i〉 (CTNNB1)〈/i〉〈/b〉 Mutations Are Not Associated with Prognosis in Advanced Hepatocellular Carcinoma
    S. Karger AG ; 2014
    In:  Oncology Vol. 87, No. 3 ( 2014), p. 159-166
    Details
    In: Oncology, S. Karger AG, Vol. 87, No. 3 ( 2014), p. 159-166
    Abstract: 〈 b 〉 〈 i 〉 Objectives: 〈 /i 〉 〈 /b 〉 Mutation of the exon 3 of 〈 i 〉 CTNNB1 〈 /i 〉 , the coding gene of β-catenin, is a crucial molecular mechanism leading to aberrant activation of the Wnt/β-catenin pathway, which is highly associated with the carcinogenesis of hepatocellular carcinoma (HCC). The prevalence and clinical significance of 〈 i 〉 CTNNB1 〈 /i 〉 mutations in advanced HCC remain unclear. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Patients with advanced HCC and available pathologic tissues (either obtained when diagnosed at advanced or early stages) were enrolled in this study. Direct sequencing of exon 3 of 〈 i 〉 CTNNB1 〈 /i 〉 was performed to detect somatic mutations. The associations between 〈 i 〉 CTNNB1 〈 /i 〉 mutations and clinicopathologic features were analyzed. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 A total of 115 patients were enrolled, among whom 78 (67.8%) had chronic hepatitis B virus infection. Twenty-one (18.3%) patients were found to have 〈 i 〉 CTNNB1 〈 /i 〉 mutations, all of which were missense mutations. The 〈 i 〉 CTNNB1 〈 /i 〉 mutation rates were similar among pathologic tissues obtained at advanced and early stages (17.5 and 20.0%, respectively). Patients aged over 60 years were more likely to have 〈 i 〉 CTNNB1 〈 /i 〉 mutations than patients younger than 60 years (32.6 vs. 8.7%, p = 0.001). The mutations were not associated with survival or other clinicopathologic features. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 In patients with advanced HCC, 〈 i 〉 CTNNB1 〈 /i 〉 mutations were not prognostically significant. No apparent increase of 〈 i 〉 CTNNB1 〈 /i 〉 mutations occurred during the progression of HCC.
    Type of Medium: Online Resource
    ISSN: 0030-2414 , 1423-0232
    URL: Article
    DOI: 10.1159/000362821
    RVK:
    XH 3305
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2014
    detail.hit.zdb_id: 1483096-6
    detail.hit.zdb_id: 250101-6
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  • 3
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    Online Resource
    Noninvasive Prenatal Testing for Whole Fetal Chromosomal Aneuploidies: A Multicenter Prospective Cohort Trial in Taiwan
    S. Karger AG ; 2014
    In:  Fetal Diagnosis and Therapy Vol. 35, No. 1 ( 2014), p. 13-17
    Details
    In: Fetal Diagnosis and Therapy, S. Karger AG, Vol. 35, No. 1 ( 2014), p. 13-17
    Abstract: 〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 To evaluate the performance of noninvasive prenatal testing for all fetal chromosomal aneuploidies in an extremely high-risk group undergoing first trimester combined Down syndrome screening. 〈 b 〉 〈 i 〉 Method: 〈 /i 〉 〈 /b 〉 A multicenter cohort prospective study in Taiwan was performed between June and December 2012. Maternal plasma was collected and shotgun massive parallel sequencing was performed on each fetal chromosome. 201 Taiwanese pregnant women at 〉 12 weeks' gestation from 11 medical centers were enrolled in this trial. The extremely high-risk group was defined as a Down syndrome risk cutoff 〉 1:30 or nuchal translucency 〉 3.0 mm (n = 100), while the low-risk group was defined as a Down syndrome cutoff 〈 1:1,500 (n = 101). Amniocentesis confirmation was performed and birth outcome was also recorded. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 There were 11 cases of trisomy 21, 8 cases of trisomy 18, 3 cases of trisomy 13, 1 case of trisomy 16, 3 cases of 45,X, and 1 case of 47,XYY detected prenatally in 100 extremely high-risk gravidas [n = 27/100 (27%)]. The ov erall autosomal or sex chromosome aneuploidy detection rate was 96% (27/28) because of an insufficient amount maternal plasma for one fetus with Turner syndrome. In the low-risk group, no chromosomal abnormalities were detected (specificity = 100%). There were no false-positive cases in this study. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 This first trial in Taiwan shows that noninvasive prenatal testing for whole chromosome aneuploidies can be efficiently applied in extremely high- and low-risk populations.
    Type of Medium: Online Resource
    ISSN: 1015-3837 , 1421-9964
    URL: Article
    DOI: 10.1159/000355407
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2014
    detail.hit.zdb_id: 1482292-1
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  • 4
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    Online Resource
    The Kinmen Neurological Disorders Survey (KINDS): A Study of a Chinese Population
    S. Karger AG ; 1997
    In:  Neuroepidemiology Vol. 16, No. 2 ( 1997), p. 60-68
    Details
    In: Neuroepidemiology, S. Karger AG, Vol. 16, No. 2 ( 1997), p. 60-68
    Type of Medium: Online Resource
    ISSN: 0251-5350 , 1423-0208
    URL: Article
    DOI: 10.1159/000109672
    Language: English
    Publisher: S. Karger AG
    Publication Date: 1997
    detail.hit.zdb_id: 1483032-2
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  • 5
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    Online Resource
    Efficacy, Safety, and Potential Biomarkers of Thalidomide plus Metronomic Chemotherapy for Advanced Hepatocellular Carcinoma
    S. Karger AG ; 2012
    In:  Oncology Vol. 82, No. 1 ( 2012), p. 59-66
    Details
    In: Oncology, S. Karger AG, Vol. 82, No. 1 ( 2012), p. 59-66
    Abstract: 〈 i 〉 Objectives: 〈 /i 〉 Thalidomide has been shown to have antitumor activity in some patients with advanced hepatocellular carcinoma (HCC). We initiated a phase II study to determine the safety and efficacy of adding metronomic chemotherapy to thalidomide as first-line therapy. 〈 i 〉 Methods: 〈 /i 〉 This open- labeled, single-arm, multicentered, investigator-initiated study enrolled patients with treatment-naïve advanced HCC not amenable to locoregional therapies. Treatment included oral thalidomide (100 mg twice daily) and tegafur/uracil [125 mg/m 〈 sup 〉 2 〈 /sup 〉 (based on tegafur) twice daily]. Tumor assessment was performed according to Response Evaluation Criteria in Solid Tumors (RECIST) 1.0. Pretreatment plasma levels of angiogenesis factors were correlated with patient outcomes. 〈 i 〉 Results: 〈 /i 〉 Forty-three patients were included. Sixteen (37%) patients had a Cancer of the Liver Italian Program (CLIP) score of 4, and 31 (72%) patients had chronic hepatitis B virus infection. The objective response rate was 9%, and the disease stabilization rate was 33%. The median progression-free survival was 1.9 months (95% CI 1.7–2.1 months), and the median OS was 4.6 months (95% CI 2.3–6.9 months). Treatment was generally tolerable. High baseline plasma levels of interleukin (IL)-6 and IL-8 were adversely correlated with patient survivals. 〈 i 〉 Conclusions: 〈 /i 〉 The combination of thalidomide and tegafur/uracil was safe and demonstrated modest activity in patients with advanced HCC.
    Type of Medium: Online Resource
    ISSN: 0030-2414 , 1423-0232
    URL: Article
    DOI: 10.1159/000336126
    RVK:
    XH 3305
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2012
    detail.hit.zdb_id: 1483096-6
    detail.hit.zdb_id: 250101-6
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  • 6
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    Online Resource
    Neural Substrates of Amphetamine-Induced Behavioral Sensitization: Unconditioned (Zero Context) and Conditioned (Switch versus Same Context) Components in c-〈b〉〈i〉fos〈/i〉〈/b〉 Overexpression
    S. Karger AG ; 2013
    In:  Neuropsychobiology Vol. 67, No. 1 ( 2013), p. 48-60
    Details
    In: Neuropsychobiology, S. Karger AG, Vol. 67, No. 1 ( 2013), p. 48-60
    Abstract: The neural substrates of the unconditioned and conditioned components of amphetamine (AMPH)-induced behavioral sensitization remain unknown. The present study examines the brain activation of rats in response to an AMPH challenge with augmented locomotion in groups receiving chronic AMPH under chloral hydrate anesthetization (i.e., the ‘zero context’) or when tested in the ‘same context’ as a chronic treatment, or when tested in a ‘different context’. The neural activations of the three groups reveal fairly consistent patterns: (a) The substantia nigra is activated in the same context condition and the pure AMPH effect (i.e., the zero context with the unconditioned component), but not in the switch context condition. (b) The ventral pallidum showed Fos expression in the switch context and the same context, but not in the zero context condition. (c) The other nuclei, including the medial prefrontal cortex, nucleus accumbens, caudate putamen, medial thalamus, hippocampus, amygdala, and ventral tegmental area, are activated in all contextual conditions and the pure AMPH effect (the zero context). The context exerts definable effects on the mesocorticolimbic dopamine system on AMPH-induced behavioral sensitization. (d) The ventral pallidum and the substantia nigra activations dissociate the unconditioned component from the conditioned component in behavioral sensitization. Further studies are needed to determine how these two nuclei mediate the effect in terms of primary and conditioned rewards.
    Type of Medium: Online Resource
    ISSN: 0302-282X , 1423-0224
    URL: Article
    DOI: 10.1159/000343670
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2013
    detail.hit.zdb_id: 1483094-2
    SSG: 5,2
    SSG: 15,3
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  • 7
    Online Resource
    Online Resource
    Carotid Ultrasound Criteria for Detecting Intracranial Carotid Stenosis
    S. Karger AG ; 2007
    In:  European Neurology Vol. 57, No. 3 ( 2007), p. 156-160
    Details
    In: European Neurology, S. Karger AG, Vol. 57, No. 3 ( 2007), p. 156-160
    Abstract: 〈 i 〉 Background/Aims: 〈 /i 〉 This study attempted to establish carotid ultrasound criteria for identifying stenosis of the intracranial internal carotid artery (ICA) and middle cerebral artery (MCA). 〈 i 〉 Methods: 〈 /i 〉 Two hundred and fifty-five patients were enrolled. Ultrasound measurements for common carotid artery (CCA) and ICA were as follows: flow volume (FV), peak systolic velocity (PSV), end-diastolic velocity (EDV), pulsatility index (PI) and resistance index (RI). The sensitivity and specificity of the ultrasound criteria for determining intracranial ICA or MCA ≧50% stenosis were calculated. 〈 i 〉 Results: 〈 /i 〉 The criteria identified for detecting intracranial ICA ≧50% stenosis were ICA FV 〈 159 ml/min, ICA PSV 〈 33 cm/s and CCA PSV 〈 42 cm/s. When ICA PSV 〈 33 cm/s was combined with CCA PSV 〈 42 cm/s, sensitivity increased to 82%, with 91% specificity. The criteria identified for detecting MCA ≧50% stenosis were CCA FV 〈 285 ml/min, ICA FV 〈 179 ml/min, ICA PSV 〈 33 cm/s, 〉 35% reduction in FV in the CCA, 〉 40% reduction in FV in ICA, and 〉 35% reduction in PSV in ICA. When these criteria were combined, sensitivity increased to 69%, with 85% specificity. 〈 i 〉 Conclusion: 〈 /i 〉 This study demonstrated that ultrasound criteria are sensitive and specific for detecting intracranial ICA and MCA significant obstruction.
    Type of Medium: Online Resource
    ISSN: 0014-3022 , 1421-9913
    URL: Article
    DOI: 10.1159/000098467
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2007
    detail.hit.zdb_id: 1482237-4
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  • 8
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    Online Resource
    Classical Hairy Cell Leukemia and Its Variant: A 17-Year Retrospective Survey in Taiwan Chinese
    S. Karger AG ; 2011
    In:  Acta Haematologica Vol. 126, No. 3 ( 2011), p. 186-193
    Details
    In: Acta Haematologica, S. Karger AG, Vol. 126, No. 3 ( 2011), p. 186-193
    Abstract: 〈 i 〉 Background: 〈 /i 〉 Classical hairy cell leukemia (HCL-C) and its variant (HCL-V) are rare chronic B-cell lymphoproliferative disorders. Only a few reports in Chinese patients are available. 〈 i 〉 Methods: 〈 /i 〉 We retrospectively reviewed 16 patients with HCL-C and HCL-V in Taiwan over a 17-year period. 〈 i 〉 Results: 〈 /i 〉 Eight were HCL-C and 8 were HCL-V. All HCL accounted for 0.7% of all adult leukemias. Compared to HCL-V, HCL-C was characterized by profound leukopenia, monocytopenia, thrombocytopenia and fewer circulating hairy cells. One HCL-C and 2 HCL-V patients had second malignancies. Seven HCL-C patients achieved hematological remission after splenectomy (n = 1) or 2-chlorodeoxyadenosine (n = 6). Of the 8 HCL-V patients, 6 received splenic irradiation. Only one achieved complete remission and another had partial remission; relapse or disease progression was noted 13.4 or 25.7 months later, respectively. Two of three HCL-V patients who underwent splenectomy had stable disease. All patients with HCL-C were alive while 3 with HCL-V expired. Compared to HCL-C, HCL-V had a significantly shorter leukemia-free survival. 〈 i 〉 Conclusion: 〈 /i 〉 A relatively higher proportion of HCL-V in all HCL comparing to Westerners is observed. Second malignancies are common. With an inferior outcome and dismal response to most treatment, enrollment in a clinical trial should be considered for HCL-V.
    Type of Medium: Online Resource
    ISSN: 0001-5792 , 1421-9662
    URL: Article
    DOI: 10.1159/000328887
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2011
    detail.hit.zdb_id: 1481888-7
    detail.hit.zdb_id: 80008-9
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