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  • 1995-1999  (2)
  • Natural Sciences  (2)
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  • 1995-1999  (2)
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  • Natural Sciences  (2)
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  • 1
    Online Resource
    Online Resource
    Wiley ; 1998
    In:  Annals of the New York Academy of Sciences Vol. 855, No. 1 ( 1998-11), p. 652-656
    In: Annals of the New York Academy of Sciences, Wiley, Vol. 855, No. 1 ( 1998-11), p. 652-656
    Abstract: ABSTRACT: Draize eye scores (DES) of 37 pure organic liquids have been converted into scores for the corresponding vapors, DES/P 0 , where P 0 is the liquid vapor pressure in atmospheres at 298 K. It is shown that there is a constant difference of 6.7 between values of log(DES/P 0 ) and log (1/EIT), where EIT is the eye irritation threshold in parts per million (ppm, by volume) of eight vapors for human subjects. The 37 log(DES/P 0 ) values can be combined with log(1/EIT) values for 17 vapors into one quantitative structure‐activity relationship (QSAR) for sensory potency (SP) using our general solvation equation, Equation 1 image where R 2 is an excess molar refraction, π 2 H the compound polarizability/dipolarity, Σα 2 H and Σβ 2 H are the compound hydrogen‐bond acidity and basicity, and L 16 is the gas‐hexadecane partition coefficient at 298 K. n is the number of data points, r the correlation coefficient, SD the standard deviation, and F the F ‐statistic. LogSP is then either [log(DES/P 0 ) ‐ 0.66] or log (1/EIT), confirming the result for the eight common compounds. It is suggested that the equation can be used to predict eye irritancy of organic vapors and pure liquids. It is further suggested that for the compounds in the data set, the main process in eye irritation is transfer of the compound from the vapor or pure liquid to a biological phase, and a number of chemical properties of the biological phase have been mapped out through the equation. These properties are consistent with corresponding properties for a number of organic liquid phases.
    Type of Medium: Online Resource
    ISSN: 0077-8923 , 1749-6632
    URL: Issue
    RVK:
    Language: English
    Publisher: Wiley
    Publication Date: 1998
    detail.hit.zdb_id: 2834079-6
    detail.hit.zdb_id: 211003-9
    detail.hit.zdb_id: 2071584-5
    SSG: 11
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Online Resource
    Online Resource
    Wiley ; 1998
    In:  Annals of the New York Academy of Sciences Vol. 855, No. 1 ( 1998-11), p. 648-651
    In: Annals of the New York Academy of Sciences, Wiley, Vol. 855, No. 1 ( 1998-11), p. 648-651
    Abstract: ABSTRACT: We tested four normosmics and four anosmics in detection thresholds for six terpenes commonly found indoors: cumene, p ‐cymene, delta‐3‐carene, linalool, 1,8‐cineole and geraniol. Normosmics provided odor thresholds and anosmics provided nasal pungency thresholds. All subjects provided nasal localization ( i.e. , right/left nostril) and eye irritation thresholds. Each type of threshold was measured eight times per subject‐stimulus combination. Stimuli were presented from squeeze bottles in a two‐alternative forced‐choice procedure via an ascending method of limits. Odor thresholds ranged between 0.1 and 1.0 parts per million (ppm, by volume). Nasal pungency thresholds lay about three orders of magnitude above odor thresholds. Nasal localization and eye irritation thresholds did not differ between normosmics and anosmics, and fell close to nasal pungency thresholds. Olfactory thresholds could be obtained for all stimuli in all repetitions using the criterion of five correct choices in a row. Trigeminal thresholds ( i.e. , pungency, localization and eye irritation) could be obtained on all repetitions only for some terpenes using that same criterion. Carene and cineol produced nasal pungency and eye irritation on all repetitions. None of the terpenes could be localized on all repetitions, but cineol was localized a higher percentage of instances than were the other stimuli. At the other extreme, geraniol failed to evoke any of the three trigeminal responses in most instances. Overall, the results indicate that the three trigeminal thresholds produce a uniform view of the potency of these terpenes, with nasal pungency and eye irritation being slightly more sensitive than nasal localization. Furthermore, application of a previously derived linear solvation energy relationship to the results reinforced the view that physico‐chemical properties can predict the chemesthetic impact of volatile organic compounds.
    Type of Medium: Online Resource
    ISSN: 0077-8923 , 1749-6632
    URL: Issue
    RVK:
    Language: English
    Publisher: Wiley
    Publication Date: 1998
    detail.hit.zdb_id: 2834079-6
    detail.hit.zdb_id: 211003-9
    detail.hit.zdb_id: 2071584-5
    SSG: 11
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
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