In:
Tumori Journal, SAGE Publications, Vol. 79, No. 5 ( 1993-10), p. 331-335
Abstract:
The study was performed to assess the toxicity and impact on relapse pattern of postoperative intraperitoneal cisplatin, 5-fluorouracil, leucovorin and interferon therapy as adjuvant treatment for gastric cancer patients who are at high risk for recurrence after potentially curative resection (T2 N1-2; T3-4 N any Mo). Patients and Methods Starting 14 to 21 days after potentially curative resection of primary gastric cancers, 22 patients were given intraperitoneal cisplatin, 60 mg/m 2 ; 5-fluorouracil, 1000 mg/m 2 ; 6S-leucovorin, 250 mg/m 2 ; interferon alpha 2b, 10 MU/m 2 ; every other week for six times. Results After a median follow-up of 24 months, 63 % of patients were alive and free of disease. Eight patients had recurred; five had an intraabdominal component, and 3 had extraabdominal failure. Toxicity was mild: no grade III-IV WHO toxicity was observed. Conclusions Intraperitoneal cisplatin, 5-fluorouracil, 6S-leucovorin and interferon is a tolerable therapy in the postoperative setting for patients with resected gastric cancer. These data make this approach interesting for the development of new programs of adjuvant therapy of high-risk gastric cancer.
Type of Medium:
Online Resource
ISSN:
0300-8916
,
2038-2529
DOI:
10.1177/030089169307900509
Language:
English
Publisher:
SAGE Publications
Publication Date:
1993
detail.hit.zdb_id:
280962-X
detail.hit.zdb_id:
2267832-3
Bookmarklink