In:
Journal of Bioactive and Compatible Polymers, SAGE Publications, Vol. 9, No. 2 ( 1994-04), p. 142-151
Abstract:
Four polyanion-Pt(II)-complexes, PEE-cis-DACH-Pt, PEE- cis- (ACP) 2 -Pt, PCR- cis -DACH-Pt, and PCR- cis-(ACP) 2 -Pt, were synthesized by the reactions of polyanions such as poly[(2-ethoxytetrahydropyran-5,6-diyl)(1,2- dicarboxyethylene)](PEE) and poly[(3,4-dicarboxytetrahydropyran-2,6-diyl)- (1,2-dicarboxypropylene)] (PCP) with cis-[Pt(amine) 2 ) 2 ](NO 3 ) 2 , where the amine was 1,2-diaminocyclohexane (DACH) or aminocyclopropane (ACP). The biologi cal activities of the complexes were measured in vitro against A-459 nonsmall cell lung, Sk-OV-3 ovarian, SK-Mel-2 melanoma, XF-498 CNS, and HCT-15 colon tumor cell lines. The increased life span was measured against L1210 leukemia and found to be 223% for PCP- cis-(ACP) 2 -Pt(II) at the dose of 25 mg/Kg.
Type of Medium:
Online Resource
ISSN:
0883-9115
,
1530-8030
DOI:
10.1177/088391159400900202
Language:
English
Publisher:
SAGE Publications
Publication Date:
1994
detail.hit.zdb_id:
2073790-7
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