In:
International Archives of Allergy and Immunology, S. Karger AG, Vol. 88, No. 1-2 ( 1989), p. 40-45
Abstract:
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a well-characterized hematopoietic growth factor. Recently, using purified recombinant-derived material, we have found that GM-CSF is also a potent activator of mature functional macrophages. Thus, we have found that exogenous GM-CSF augments the primary plaque-forming response to sheep red blood cells and that this effect is due to upregulation of la antigen expression and interleukin 1 production by the macrophages. We also show that GM-CSF inhibits the replication of 〈 i 〉 Trypanosoma cruzi 〈 /i 〉 in cultured peritoneal macrophages and causes an accelarated clearance of 〈 i 〉 Salmonella typhimurium 〈 /i 〉 from the peritoneal cavity of mice. These data indicate that GM-CSF is a multifunctional molecule stimulating both hematopoiesis and mature macrophage function.
Type of Medium:
Online Resource
ISSN:
1018-2438
,
1423-0097
Language:
English
Publisher:
S. Karger AG
Publication Date:
1989
detail.hit.zdb_id:
1482722-0
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