In:
FEBS Letters, Wiley, Vol. 208, No. 1 ( 1986-11-10), p. 39-42
Abstract:
In quiescent cultures of Swiss 3T3 cells, platelet‐derived growth factor or fibroblast growth factor known to induce both protein kinase C activation and Ca 2+ mobilization raised c‐ fos mRNA. This action of the growth factors was mimicked by the specific activators for protein kinase C, such as phorbol esters and a membrane‐permeable synthetic diacylglycerol, and also by the Ca 2+ ionophores, such as A23187 and ionomycin. Prostaglandin E 1 known to elevate cyclic AMP also raised c‐ fos mRNA, and this action was mimicked by 8‐bromo‐cyclic AMP, dibutyryl cyclic AMP and forskolin. These results suggest that expression of the c‐ fos gene is regulated by three different intracellular messenger systems, protein kinase C, Ca 2+ and cyclic AMP, in Swiss 3T3 cells.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/0014-5793(86)81527-7
Language:
English
Publisher:
Wiley
Publication Date:
1986
detail.hit.zdb_id:
1460391-3
SSG:
12
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