In:
European Journal of Biochemistry, Wiley, Vol. 128, No. 2-3 ( 1982-11), p. 293-296
Abstract:
Interactions between α‐adrenergic‐induced lactate production, respiration and K + uptake of perfused rat livers were investigated. Inhibition of mitochondrial electron transport by cyanide had no effect on K + uptake, decreased phenylephrine‐induced lactate production by 60% and suppressed extra O 2 consumption by more than 90%. Ouabain did not affect α‐adrenergic‐induced respiration but inhibited K + uptake and extra lactate production. Effects of ouabain and K + ‐free medium on lactate production were additive and independent of cyanide, indicating that they were mediated by extramitochondrial mechanisms. Extra ATP utilized for K+ uptake in response to phenylephrine was apparently of glycolytic rather than mitochondrial origin. We propose that α‐adrenergic‐induced lactate production is secondary to an enhanced operation of the plasma membrane (Na + ,K + )‐ATPase.
Type of Medium:
Online Resource
ISSN:
0014-2956
,
1432-1033
DOI:
10.1111/ejb.1982.128.issue-2-3
DOI:
10.1111/j.1432-1033.1982.tb06964.x
Language:
English
Publisher:
Wiley
Publication Date:
1982
detail.hit.zdb_id:
1398347-7
detail.hit.zdb_id:
2172518-4
SSG:
12
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