In:
Nepal Journal of Obstetrics and Gynaecology, Nepal Journals Online (JOL), Vol. 4, No. 1 ( 1970-01-01), p. 19-24
Abstract:
Aim: To investigate the prognostic risk factor(s) and pattern of disease relapse of patients with cervicalcarcinoma and pelvic node metastasis.Methods: One hundred twenty four cases of FIGOIB1~IIA cervical carcinoma with pelvic node metastasistreated from January 1991 to December 2001 were selected for this study. Prognosis and recurrence wereretrospectively analyzed using the clinico-pathological data.Results: The overall 5 year survival and disease-free survival (DFS) was 63.3% and 61.4% respectively.Overall recurrence rate was 39.5% (49/124). Intra-pelvic relapse (25/41, 61.0%) was significantly morefrequent than extra-pelvic relapse (13/41, 1.7%, P=0.008). Multivariate analysis identified involvement ofcommon iliac node as independent prognostic factor (P=0.035). According to this factor, node-positivepatients could be divided into low risk group (without common iliac node involvement, 104 cases) and highrisk group (with common iliac node involvement, 20 cases). The DFS were 69.4% and 24.5% respectively,and the difference was significant (P=0.003). Intra-pelvic relapse was observed in 22.1% of low risk and25.0% of high risk group respectively, the difference was not significant (P 〉 0.05), however extra-pelvicrelapse was seen in 7.7% of low risk and 40.0% of high risk group, and the difference was significant(P 〈 0.001).Conclusions: Common iliac node involvement is the significant factor that influences the prognosis ofpatients with cervical carcinoma and pelvic node metastasis. According to this factor, survival and recurrencepattern differs significantly. These findings provide important reference for individualized modification andinvestigation of treatment mode.Keywords: Cervical neoplasms; lymph node metastasis; prognosisDOI: 10.3126/njog.v4i1.3327Nepal Journal of Obstetrics and Gynaecology June-July 2009; 4(1): 19-24
Type of Medium:
Online Resource
ISSN:
1999-8546
,
1999-9623
DOI:
10.3126/njog.v4i1.3327
Language:
Unknown
Publisher:
Nepal Journals Online (JOL)
Publication Date:
1970
detail.hit.zdb_id:
2430134-6
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