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  • 1
    Online Resource
    Online Resource
    Polskie Towarzystwo Biochemiczne (Polish Biochemical Society) ; 1970
    In:  Acta Biochimica Polonica Vol. 64, No. 1 ( 1970-01-01)
    In: Acta Biochimica Polonica, Polskie Towarzystwo Biochemiczne (Polish Biochemical Society), Vol. 64, No. 1 ( 1970-01-01)
    Abstract: Numerous evidences suggested that the hepatitis B virus (HBV) was recognized as an important factor in the development of hepatocellular carcinoma (HCC). Dickkopf-1 (DKK1) recently was reported to be involved in the progress of HCC. HBV may regulate DKK1 expression in hematoma carcinogenesis. Here, we demonstrated that HBV could regulate DKK1 promoter activity which resulted in upregulation of its mRNA and protein expression in several HBV existing cell lines, and HBx played a prominent role in this process. Transcription factor binding site search result showed that there is a SP1 site in DKK1 promoter region. Luciferase assay showed that overexpression of SP1 could increase DKK1 promoter activity in a dose dependent manner. Accordingly, siRNA inhibition of SP1 expression reduced DKK1 promoter activity and decreased the expression of DKK1 protein.
    Type of Medium: Online Resource
    ISSN: 1734-154X , 0001-527X
    Language: Unknown
    Publisher: Polskie Towarzystwo Biochemiczne (Polish Biochemical Society)
    Publication Date: 1970
    detail.hit.zdb_id: 2086022-5
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  • 2
    Online Resource
    Online Resource
    AccScience Publishing ; 1970
    In:  International Journal of Bioprinting Vol. 7, No. 2 ( 1970-01-01), p. 346-
    In: International Journal of Bioprinting, AccScience Publishing, Vol. 7, No. 2 ( 1970-01-01), p. 346-
    Abstract: Poly-L-lactic acid (PLLA) lacks osteogenic activity, which limits its application in bone repair. Zinc (Zn) is widely applied to strengthen the biological properties of polymers due to its excellent osteogenic activity. In the present study, Zndoped mesoporous silica (Zn-MS) particles were synthesized by one-pot hydrothermal method. Then, the particles were induced into PLLA scaffolds prepared by selective laser sintering technique, aiming to improve their osteogenic activity. Our results showed that the synthesized particles possessed rosette-like morphology and uniform mesoporous structure, and the composite scaffold displayed the sustained release of Zn ion in a low concentration range, which was attributed to the shield effect of the PLLA matrix and the strong bonding interaction of Si-O-Zn. The scaffold could evidently promote osteogenesis differentiation of mouse bone marrow mesenchymal stem cells by upregulating their osteogenesis-related gene expression. Besides, Zn-MS particles could significantly increase the compressive strength of the PLLA scaffold because of their rosettelike morphology and mesoporous structure, which can form micromechanical interlocking with the PLLA matrix. The Zn-MS particles possess great potential to improve various polymer scaffold properties due to their advantageous morphology and physicochemical properties. & nbsp;
    Type of Medium: Online Resource
    ISSN: 2424-7723 , 2424-8002
    Language: Unknown
    Publisher: AccScience Publishing
    Publication Date: 1970
    detail.hit.zdb_id: 2834694-4
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  • 3
    Online Resource
    Online Resource
    Bio-Byword Scientific Publishing, Pty. Ltd. ; 1970
    In:  Journal of Architectural Research and Development Vol. 1, No. 2 ( 1970-01-01)
    In: Journal of Architectural Research and Development, Bio-Byword Scientific Publishing, Pty. Ltd., Vol. 1, No. 2 ( 1970-01-01)
    Abstract: The gas boiler house is responsible for heating 308,000 m2 of residents in the community, and the historical heating energy consumption reached 3,000 tons of standard coal in 2012. The heating energy consumption index in this community is higher than that of heating energy consumption index in other residential communities. The heating system in this community is tested and analyzed comprehensively in this paper. The three aspects of heating system heat source, pipe network transmission and distribution and thermal user are combed and analyzed in this paper, to look for the energy-saving potential of each link. It is found that the exhaust gas temperature is 175℃ through the test of thermal efficiency of 2 # boiler in XX Community, and the heat loss of exhaust gas is higher. Meanwhile, it is found that the exhaust gas temperature is too high in all boilers through checking the operation record. It is found that the system water recharge is larger and the problems of leaking and aging thermal insulation layer and pipeline appear in the heating network through operation record analysis and on-site inspection. The analysis shows that there is a problem of hydraulic imbalance through the on-site test on the wall temperature of the supply pipe of the hot water supply wells in the residential buildings near, middle and far-ends. Analyze the problem existing in the heating system in XX Community, and put forward some corresponding energy saving technical proposals, such as flue gas condensing waste heat recovery, hydraulic balance adjustment and pipeline insulation improvement according to on-site survey and analysis; meanwhile, estimate the energy saving effect and the investment payback period.It is expected to realize the energy saving 728.72 tce and energy saving benefit of 1.4415 million yuan through three measures for energy saving and technicalm transformation. Estimated investment cost is 3.16 million yuan.
    Type of Medium: Online Resource
    ISSN: 2208-3537 , 2208-3529
    URL: Issue
    Language: Unknown
    Publisher: Bio-Byword Scientific Publishing, Pty. Ltd.
    Publication Date: 1970
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