In:
The Journal of Immunology, The American Association of Immunologists, Vol. 78, No. 2 ( 1957-02-01), p. 79-93
Abstract:
The preparation of rabbit immune globulins from tissue cultures of human skin cells and whole human placenta is described. An assay of the cytopathogenic effect of the anti-skin immune globulin demonstrated a profound activity against human cells of ectodermal and mesodermal origin. No effect on mouse liver epithelium and mouse subcutaneous (strain L) cells was found. A selective cytotoxicity was demonstrated by the anti-placental immune globulin in vitro. Only fibroblast-like cells were destroyed in cultures of mixed cells arising from skin. The cytotoxic activity of anti-skin globulin could be effectively inhibited by the presence of chicken plasma or pooled, frozen, human serum.
Type of Medium:
Online Resource
ISSN:
0022-1767
,
1550-6606
DOI:
10.4049/jimmunol.78.2.79
Language:
English
Publisher:
The American Association of Immunologists
Publication Date:
1957
detail.hit.zdb_id:
1475085-5
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