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  • Bentham Science Publishers Ltd.  (5)
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  • Bentham Science Publishers Ltd.  (5)
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  • 1
    Online Resource
    Online Resource
    Targeting Epidermal Growth Factor Receptor in Non-Small-Cell-Lung Cancer: Current State and Future Perspective
    Bentham Science Publishers Ltd. ; 2019
    In:  Anti-Cancer Agents in Medicinal Chemistry Vol. 19, No. 8 ( 2019-08-21), p. 984-991
    Details
    In: Anti-Cancer Agents in Medicinal Chemistry, Bentham Science Publishers Ltd., Vol. 19, No. 8 ( 2019-08-21), p. 984-991
    Abstract: Lung cancer is one of the leading cause of cancer death worldwide, the most common histological type of lung cancer is non-small cell lung cancer (NSCLC), whose occurrence and development is closely related to the mutation and amplification of epidermal growth factor receptors (EGFR). Currently , a series of targeted drugs were developed on the inhibition of EGFR such as epidermal growth factor receptortyrosine kinase inhibitor EGFR-TKI and monoclonal antibody (McAb). Objective: We sought to summarizes the current drugs targeting Epidermal Growth Factor Receptor in nonsmall- cell-lung. Methods: We conducted a comprehensive review of the development and application of EGFR-TKI and McAb which targeted EGFR in NSCLC and compared the mechanisms of PROTAC with the traditional inhibitors. Results: The drugs targeted EGFR in NSCLC have been widely used in clinic practices. Compared to traditional chemotherapy, these drugs excel with their clear and specific targeting, better curative effects, and less toxic and side effects. However, the mechanism comes with some insurmountable weaknesses like serious toxic and other side effects, as well as proneness to producing drug resistance. Results: The drugs targeted EGFR in NSCLC have been widely used in clinic practices. Compared to traditional chemotherapy, these drugs excel with their clear and specific targeting, better curative effects, and less toxic and side effects. However, the mechanism comes with some insurmountable weaknesses like serious toxic and other side effects, as well as proneness to producing drug resistance. Conclusion: The emerging PROTAC (Proteolysis Targeting Chimera) technology has been successfully applied to selective degradation of multiple protein targets, including EGFR. It also highlights the potential and challenges of PROTAC therapy regarding future combination therapeutic options in NSCLC treatment.
    Type of Medium: Online Resource
    ISSN: 1871-5206
    URL: Article
    DOI: 10.2174/1871520619666190313161009
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2019
    SSG: 15,3
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  • 2
    Online Resource
    Online Resource
    cGAS-STING-mediated IFN-I Response in Host Defense and Neuroinflammatory Diseases
    Bentham Science Publishers Ltd. ; 2022
    In:  Current Neuropharmacology Vol. 20, No. 2 ( 2022-02), p. 362-371
    Details
    In: Current Neuropharmacology, Bentham Science Publishers Ltd., Vol. 20, No. 2 ( 2022-02), p. 362-371
    Abstract: The presence of foreign or misplaced nucleic acids is a dangerous signal that triggers innate immune responses by activating cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) and binding to its downstream signaling effector stimulator of interferon genes (STING). Then the cGAS-STING pathway activation links nucleic acid-sensing to immune responses and pathogenic entities clearance. However, the overactivation of this signaling pathway leads to fatal immune disorders and contributes to the progression of many human inflammatory diseases. Therefore, optimal activation of this pathway is crucial for the elimination of invading pathogens and the maintenance of immune homeostasis. In this review, we will summarize its fundamental roles in initiating host defense against invading pathogens and discuss its pathogenic roles in multiple neuro-inflammatory diseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS) and other neurodegenerative diseases.
    Type of Medium: Online Resource
    ISSN: 1570-159X
    URL: Article
    DOI: 10.2174/1570159X19666210924110144
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2022
    detail.hit.zdb_id: 2119376-9
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  • 3
    Online Resource
    Online Resource
    Targeting the Neuronal Activity of Prefrontal Cortex: New Directions for the Therapy of Depression
    Bentham Science Publishers Ltd. ; 2020
    In:  Current Neuropharmacology Vol. 18, No. 4 ( 2020-03-20), p. 332-346
    Details
    In: Current Neuropharmacology, Bentham Science Publishers Ltd., Vol. 18, No. 4 ( 2020-03-20), p. 332-346
    Abstract: Depression is one of the prevalent psychiatric illnesses with a comprehensive performance such as low self-esteem, lack of motivation, anhedonia, poor appetite, low energy, and uncomfortableness without a specific cause. So far, the cause of depression is not very clear, but it is certain that many aspects of biological psychological and social environment are involved in the pathogenesis of depression. Recently, the prefrontal cortex (PFC) has been indicated to be a pivotal brain region in the pathogenesis of depression. And increasing evidence showed that the abnormal activity of the PFC neurons is linked with depressive symptoms. Unveiling the molecular and cellular, as well as the circuit properties of the PFC neurons will help to find out how abnormalities in PFC neuronal activity are associated with depressive disorders. In addition, concerning many antidepressant drugs, in this review, we concluded the effect of several antidepressants on PFC neuronal activity to better understand its association with depression.
    Type of Medium: Online Resource
    ISSN: 1570-159X
    URL: Article
    DOI: 10.2174/1570159X17666191101124017
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2020
    detail.hit.zdb_id: 2119376-9
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  • 4
    Online Resource
    Online Resource
    Molecular Interactions During Borrelia burgdorferi Migration from the Vector to the Mammalian Nervous System
    Bentham Science Publishers Ltd. ; 2020
    In:  Current Protein & Peptide Science Vol. 21, No. 5 ( 2020-06-02), p. 517-526
    Details
    In: Current Protein & Peptide Science, Bentham Science Publishers Ltd., Vol. 21, No. 5 ( 2020-06-02), p. 517-526
    Abstract: Lyme disease (LD) is an infectious disease caused by the spirochetes of genus borrelia, which are transmitted by the ticks of the genus ixodes. LD is transmitted by the spirochete B. burgdorferi sensu lato. Once in contact with the host through a tick bite, the pathogen comes into contact with the host defense, and must escape this machinery to establish LD, thus using a large number of mechanisms involving the vector of the pathogen, the pathogen itself and also the host. The initial diagnosis of the disease can be made based on the clinical symptoms of LD and the disease can be treated and cured with antibiotics if the diagnosis is made early in the beginning of the disease. Contrariwise, if LD is left untreated, the pathogen disseminates throughout the tissues and organs of the body, where it establishes different types of disease manifestations. In the nervous system, the inflammation caused by B. burgdorferi is known as Lyme neuroborreliosis (LNB). LNB is one of the principal manifestations of LD. In this review, we systematically describe the different molecular interactions among B. burgdorferi, the vector (tick) and the mammalian host.
    Type of Medium: Online Resource
    ISSN: 1389-2037
    URL: Article
    DOI: 10.2174/1389203720666191015145714
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2020
    SSG: 12
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  • 5
    Online Resource
    Online Resource
    Research on Orbit Assembly Strategy of Large-scale Space Truss Structure
    Bentham Science Publishers Ltd. ; 2022
    In:  Recent Patents on Engineering Vol. 17, No. 1 ( 2022-01)
    Details
    In: Recent Patents on Engineering, Bentham Science Publishers Ltd., Vol. 17, No. 1 ( 2022-01)
    Abstract: With the rapid development of spatial technology and mankind's continuous exploration of the space domain, expandable space trusses play an important role in the construction of space station piggyback platforms. Therefore, the study of the in-orbit assembly strategy for space trusses has become increasingly important in recent years. The spatial truss assembly strategy proposed in this paper is fast and effective, and it is applied for the construction of future large-scale space facilities effectively. Objective: The four-prismatic truss periodic module is taken as the research object, and the assembly process of the truss and the assembly behaviors of the spatial cellular robot serving for on-orbit assembly are expressed. Methods: The article uses a reinforcement learning algorithm to study the coupling of truss assembly sequence and robot action sequence, then uses a q-learning algorithm to plan the strategy of the truss cycle module. Results: The robot is trained through the greedy strategy and avoids the failure problem caused by assembly uncertainty. The simulation experiment proves that the Q-learning algorithm of reinforcement learning used for planning the on-orbit assembly sequence of the truss periodic module structures is feasible, and the optimal assembly sequence with the least number of assembly steps obtained by this strategy. Conclusion: In order to address the on-orbit assembly issues of large spatial truss structures in the space environment, we trained the robots through greedy strategy to prevent failure due to the uncertainty conditions both in the strategy analysis and in the simulation study. Finally, the Q-learning algorithm in reinforcement learning is used to plan the on-orbit assembly sequence in the truss cycle module, which can obtain the optimal assembly sequence in the minimum number of assembly steps.
    Type of Medium: Online Resource
    ISSN: 1872-2121
    URL: Article
    DOI: 10.2174/1872212116666211230121623
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2022
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