In:
Journal of Medical Biochemistry, Centre for Evaluation in Education and Science (CEON/CEES), Vol. 38, No. 4 ( 2019-01-22), p. 461-467
Abstract:
Methylenetetrahydrofolate reductase ( MTHFR ) gene polymorphisms have been associated with overweight people and obesity. The goal of this study was to investigate the relationship of the MTHFR 677C 〉 T polymorphism with obesity and biochemical variables in young individuals of Mexico. Methods A total of 316 young individuals were included in the study, 172 with normal weight (NW) and 144 with over weight/obesity. Body mass index (BMI) was classified as NW, overweight, and obesity. Also, waist circumference was measured. Moreover, glucose, total cholesterol, and triglycerides were determined. Genotyping for MTHFR 677C 〉 T polymorphism was performed by the PCR-RFLP method. Results There was no difference in the distribution of the MTHFR 677C 〉 T polymorphism between individuals with NW and overweight/obesity; neither when they were divided by overweight vs NW, nor when we contrasted obese vs NW. However, an analysis stratified by gender showed a significant protector effect of the TT genotype against obesity in males and elevated waist circumference in females. Also, overweight/obese individuals with TT genotype had less risk of high cholesterol or triglycerides than overweight/obese subjects with the other genotypes. Conclusions These results suggest that the MTHFR 677T polymorphism might not be a risk factor for being overweight/obesity. Rather, on the basis of our results, this variant could be a protector effect. However, further large-scale population-based studies are still necessary to clarify the role of the MTHFR 677C 〉 T polymorphism in overweight, obesity, and lipid profile level.
Type of Medium:
Online Resource
ISSN:
1452-8266
DOI:
10.2478/jomb-2018-0046
Language:
Unknown
Publisher:
Centre for Evaluation in Education and Science (CEON/CEES)
Publication Date:
2019
detail.hit.zdb_id:
2405112-3
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