In:
Journal of Diabetes Research, Hindawi Limited, Vol. 2016 ( 2016), p. 1-7
Abstract:
Immune phenotyping provides insight into disease pathogenesis and prognostic markers. Trajectories from age of 4 to 36 weeks were modeled for insulin autoantibodies and for leukocyte subpopulations in peripheral blood from female NOD ( n = 58 ) and NOR ( n = 22 ) mice. NOD mice had higher trajectories of insulin autoantibodies, CD4 + and CD8 + T lymphocytes, B lymphocytes, IgD + IgM − B lymphocytes, and NK cells and lower trajectories of CD4 + CD25 + T lymphocytes, IgM + B lymphocytes, granulocytes, and monocytes than NOR mice (all p 〈 0.001 ). Of these, only the increased IAA trajectory was observed in NOD mice that developed diabetes as compared to NOD mice that remained diabetes-free. Therefore, the profound differences in peripheral blood leukocyte proportions observed between the diabetes-prone NOD mice and the diabetes-resistant mice do not explain the variation in diabetes development within NOD mice and do not provide markers for diabetes prediction in this model.
Type of Medium:
Online Resource
ISSN:
2314-6745
,
2314-6753
DOI:
10.1155/2016/4208156
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2016
detail.hit.zdb_id:
2711897-6
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