In:
ISRN Pediatrics, Hindawi Limited, Vol. 2011 ( 2011-01-24), p. 1-9
Abstract:
Objective . We assessed adolescent anthropometry, lipids, insulin, glucose, and blood pressures to identify factors associated with high-sensitivity C-reactive protein (hsCRP) and its tracking in young adults. Methods . Ten-year prospective study of 589 schoolgirls, 321 black, 268 white. Results . HsCRP did not differ ( P 〉 .08 ) by race or oral contraceptive use. HsCRP tracked from age 16 to 25 ( r = 0.77 ), 16 to 26 ( r = 0.50 ), 24 to 26 ( r = 0.66 ), and 25 to 26 ( r = 0.71 ), all P ≤ .02 . By stepwise regression, at age 16, waist circumference accounted for 44.8% of hsCRP variance; BMI accounted for 33.1%, 34.4%, and 31.1% at ages 24, 25, and 26, P 〈 .0001 for all. Changes in cholesterol and BMI were associated with change in hsCRP from age 24–26 (partial R 2 = 12.3 % P 〈 .0001 , 6.6% P = .0012 ). Changes in BMI and triglyceride (partial R 2 = 8.5 % P = .0001 , 3.3%, P = .0045 ) were associated with change in hsCRP from age 25 to 26. Conclusions . HsCRP tracks from age 16 to 26, with BMI, waist circumference, and cholesterol as major determinants.
Type of Medium:
Online Resource
ISSN:
2090-469X
,
2090-4703
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2011
detail.hit.zdb_id:
2603570-4
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