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  • Hindawi Limited  (14)
  • 1
    Online Resource
    Online Resource
    Elevated Blood Urea Nitrogen-to-Serum Albumin Ratio as a Factor That Negatively Affects the Mortality of Patients with Hospital-Acquired Pneumonia
    Hindawi Limited ; 2019
    In:  Canadian Journal of Infectious Diseases and Medical Microbiology Vol. 2019 ( 2019-06-16), p. 1-6
    Details
    In: Canadian Journal of Infectious Diseases and Medical Microbiology, Hindawi Limited, Vol. 2019 ( 2019-06-16), p. 1-6
    Abstract: This study aimed to evaluate the factors that affect 30-day mortality of patients with HAP. The data used in this study were collected from all HAP occurred in our hospital between January 2014 and December 2017. A total of 1158 cases were included. 150 (13.0%) of whom died within 30 days. This reported mortality identified by the univariate Cox regression analysis is found to have been affected by the following factors: age greater than 70 years, presence of diabetes mellitus and chronic obstructive pulmonary disease, gastric tube intubation, administration of proton-pump inhibitor, blood albumin level less than 30 g/l, elevated neutrophil-to-lymphocyte ratio, antibiotics therapy in the preceding 90 days, intensive care unit (ICU) admission, blood lymphocyte count less than 0.8 × 10 9 /L, elevated blood urea nitrogen/albumin (BUN/ALB) level, and presence of multidrug-resistant (MDR) pathogens. In the second multivariate analysis, administration of proton-pump inhibitor, administration of antibiotics in the preceding 90 days, ICU admission, blood lymphocyte count less than 0.8 × 10 9 /L, elevated BUN/ALB level, and presence of MDR pathogens were still associated with 30-day mortality. The area under the receiver operating characteristic curves in the BUN/ALB predicting 30-day mortality due to HAP was 0.685. A high BUN/ALB was significantly associated with a worse survival than a low BUN/ALB P 〈 0.001 . Therefore, an elevated BUN/ALB level is a risk factor for mortality on patients with HAP.
    Type of Medium: Online Resource
    ISSN: 1712-9532 , 1918-1493
    URL: Article
    DOI: 10.1155/2019/1547405
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2207109-X
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  • 2
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    Online Resource
    Serum and Ectopic Endometrium from Women with Endometriosis Modulate Macrophage M1/M2 Polarization via the Smad2/Smad3 Pathway
    Hindawi Limited ; 2018
    In:  Journal of Immunology Research Vol. 2018 ( 2018-09-12), p. 1-14
    Details
    In: Journal of Immunology Research, Hindawi Limited, Vol. 2018 ( 2018-09-12), p. 1-14
    Abstract: Objective . This study investigated the alterations in macrophage polarization in patients with endometriosis as well as the underlying molecular mechanisms. Methods . Peritoneal washings, serum samples, and endometrial tissues were collected from endometriosis patients and control subjects. Endometrial stromal cells (ESCs) were isolated from endometrial tissue, and conditioned medium was prepared by treating ESCs with or without various concentrations of interleukin- (IL-) 6, estrogen, or progestin. The frequencies of CD86+ and CD163+ cells and expression levels of these markers as well as the cytokines IL-12 and IL-10 were measured in THP-1- (human monocytic leukemia cell) derived macrophages. Results . There was a decrease in the percentage of CD86+ macrophages in the peritoneal wash solution of patients with endometriosis. Ectopic endometrial homogenates could promote M1 to M2 macrophage polarization in response to lipopolysaccharide (LPS), as evidenced by the increased percentage of CD163+ macrophages and increased IL-10 expression as well as a decreased percentage of CD86+ cells and lower IL-12 expression. In contrast, addition of serum from women with endometriosis to THP-1 cells resulted in the polarization of macrophages towards both M1 and M2 phenotypes. Upregulation of Smad2/Smad3 in macrophages upon exposure to eutopic and ectopic endometrial homogenates as well as serum of women with endometriosis was observed, and blockage of Smad2/Smad3 with their inhibitor SB431542 could reverse the macrophage polarization from M1 to M2. Conditioned medium induced by IL-6, but neither estrogen nor progestin, could facilitate M2 polarization. Neutralization of IL-6 diminished macrophage M2 polarization in endometriosis. Conclusion . This study provides detailed evidence supporting alterations in M1 to M2 macrophage polarization that may contribute to the initiation as well as progression of endometriosis.
    Type of Medium: Online Resource
    ISSN: 2314-8861 , 2314-7156
    URL: Article
    DOI: 10.1155/2018/6285813
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2817541-4
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  • 3
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    Cooperative Evolution Mechanism of Unmanned Swarm within the Framework of Public Goods Game
    Hindawi Limited ; 2021
    In:  Mathematical Problems in Engineering Vol. 2021 ( 2021-4-5), p. 1-12
    Details
    In: Mathematical Problems in Engineering, Hindawi Limited, Vol. 2021 ( 2021-4-5), p. 1-12
    Abstract: One of the key advantages of unmanned swarm operation is its autonomous cooperation. When the communication is interrupted or the centralized control manner is lost, the cooperative operation can still be carried out orderly. This work proposed a cooperative evolution mechanism within the framework of multiplayer public goods game to solve the problem of autonomous collaboration of unmanned swarm in case of failure of centralized control. It starts with the requirement analysis of autonomous cooperation in unmanned swarm, and then, the evolutionary game model of multiplayer public goods based on aspiration-driven dynamics is established. On this basis, the average abundance function is constructed by theoretical derivation, and furthermore, the influence of cost, multiplication factor, and aspiration level on the average abundance is simulated. Finally, the evolutionary mechanism of parameter adjustment in swarm cooperation is revealed via case study, and deliberate proposals are suggested to provide a meaningful exploration in the actual control of unmanned swarm cooperation.
    Type of Medium: Online Resource
    ISSN: 1563-5147 , 1024-123X
    URL: Article
    DOI: 10.1155/2021/5575815
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2014442-8
    SSG: 11
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  • 4
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    Online Resource
    PA-LBF: Prefix-Based and Adaptive Learned Bloom Filter for Spatial Data
    Hindawi Limited ; 2023
    In:  International Journal of Intelligent Systems Vol. 2023 ( 2023-3-29), p. 1-19
    Details
    In: International Journal of Intelligent Systems, Hindawi Limited, Vol. 2023 ( 2023-3-29), p. 1-19
    Abstract: The recently proposed learned bloom filter (LBF) opens a new perspective on how to reconstruct bloom filters with machine learning. However, the LBF has a massive time cost and does not apply to multidimensional spatial data. In this paper, we propose a prefix-based and adaptive learned bloom filter (PA-LBF) for spatial data, which efficiently supports the insertion and deletion. The proposed PA-LBF is divided into three parts: (1) the prefix-based classification. The Z-order space-filling curve is used to extract data, prefix it, and classify it. (2) The adaptive learning process. The multiple independent adaptive sub-LBFs are designed to train the suffixes of data, combined with part 1, to reduce the false positive rate (FPR), query, and learning process time consumption. (3) The backup filter uses CBF. Two kinds of backup CBF are constructed to meet the situation of different insertion and deletion frequencies. Experimental results prove the validity of the theory and show that the PA-LBF reduces the FPR by 84.87%, 79.53%, and 43.01% with the same memory usage compared with the LBF on three real-world spatial datasets. Moreover, the time consumption of PA-LBF can be reduced to 5 × and 2.05 × that of the LBF on the query and learning process, respectively.
    Type of Medium: Online Resource
    ISSN: 1098-111X , 0884-8173
    URL: Article
    DOI: 10.1155/2023/4970776
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2023
    detail.hit.zdb_id: 2002369-8
    SSG: 24,1
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  • 5
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    Online Resource
    Qinggan Huoxue Recipe Protects against Experimental Alcoholic Liver Fibrosis through CXCL16 Inhibition
    Hindawi Limited ; 2023
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2023 ( 2023-1-3), p. 1-14
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2023 ( 2023-1-3), p. 1-14
    Abstract: Background. Qinggan Huoxue recipe (QGHXR), a traditional Chinese medicinal formula, has a protective effect against liver fibrosis. However, the underlying mechanisms remain unclear. Objective. This study investigated the antifibrotic role of QGHXR and its underlying mechanisms. Methods. The composition of QGHXR was determined using ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Female C57BL/6J mice were fed either a Lieber–DeCarli liquid diet or pair-fed control diet and intraperitoneally injected with CCl4 for 8 weeks (n = 8). In week 5, the mice were administered 100, 200, and 400 mg/kg QGHXR via oral gavage daily for 4 weeks. Results. UPLC-MS result showed that QGHXR contained 45 compounds including salvianolic acid A, scutellarin, baicalin, rutin, and chai saponin D. QGHXR alleviated pathological alterations in the liver. The alanine aminotransferase (ALT) level was reduced to 44.88 ± 4.39 U/L, aspartate aminotransferase (AST) to 76.25 ± 4.17 U/L, alkaline phosphatase (ALP) to 60.75 ± 5.41 U/L, and acetaldehyde to 38.54 ± 1.01 U/L compared with that of the control group (ALT 72.38 ± 5.19 U/L, AST 119.63 ± 9.82 U/L, and ALP 98.63 ± 6.71 U/L and acetaldehyde 64.86 ± 4.70 U/L). QGHXR inhibited lipid overproduction and fibrotic gene expression. The serum concentration of chemokine C-X-C ligand 16 (CXCL16) was reduced to 62.83 ± 6.80 pg/ml compared with that of the control group (130.91 ± 13.72 pg/mL). QGHXR downregulated CXCL16 mRNA and protein expressions. Pharmacological CXCL16 treatment reversed the QGHXR-induced protective effects in ethanol plus CCl4 fed mice. QGHXR reduced CXCL16 levels (91.97 ± 5.86 pg/ml) in LPS-stimulated RAW264.7 cells compared with that of the control group (148.68 ± 8.62 pg/ml) and inhibited toll-like receptor 4 and nuclear factor-kappa B phosphorylation. Conclusions. This study demonstrated that QGHXR mitigates experimental alcoholic liver fibrosis by CXCL16 inhibition, and may be considered a potential therapeutic agent for treating liver fibrosis.
    Type of Medium: Online Resource
    ISSN: 1741-4288 , 1741-427X
    URL: Article
    DOI: 10.1155/2023/5642713
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2023
    detail.hit.zdb_id: 2148302-4
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  • 6
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    The Risk Factors for Nosocomial Infection in Chinese Patients with Active Rheumatoid Arthritis in Shanghai
    Hindawi Limited ; 2012
    In:  ISRN Rheumatology Vol. 2012 ( 2012-03-19), p. 1-5
    Details
    In: ISRN Rheumatology, Hindawi Limited, Vol. 2012 ( 2012-03-19), p. 1-5
    Abstract: Objective . To analyse the potential risk factors of nosocomial infections in patients with active rheumatoid arthritis (RA). Methods . A total of 2452 active RA patients at Hospitals in Shanghai between January 2009 and February 2011 were analyzed. Their demographic and clinical characteristics were compared with those without infection, and the potential risk factors were determined by logistic regression analysis. Results . Multivariate analysis indicated the gender ( OR = 0.70 , 95% CI 0.53–0.92), duration in hospital ( OR = 1.03 , 95%CI 1.01–1.05), number of organs involved ( OR = 0.82, 95%CI 0.72–0.92), number of disease-modifying antirheumatic drugs ((DMARDs) ( OR = 1.22, 95%CI 1.061–1.40)), corticosteroid therapy ( OR = 1.02, 95%CI 1.01–1.03), peripheral white blood cell counts ((WBC) ( OR = 1.04, 95%CI 1.00–1.08)), levels of serum albumin ( OR = 0.98 , 95%CI 0.97–0.99), and C-reactive protein ((CRP) ( OR = 1.03 , 95%CI 1.01–1.04)) that were significantly associated with the risk of infections. Conclusion . The female patients, longer hospital stay, more organs involved, more DMARDs, corticosteroid usage, high counts of WBC, lower serum albumin, and higher serum CRP were independent risk factors of infections in active RA patients.
    Type of Medium: Online Resource
    ISSN: 2090-5475
    URL: Article
    DOI: 10.5402/2012/215692
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2012
    detail.hit.zdb_id: 2604664-7
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  • 7
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    CBCT-Aided Microscopic and Ultrasonic Treatment for Upper or Middle Thirds Calcified Root Canals
    Hindawi Limited ; 2016
    In:  BioMed Research International Vol. 2016 ( 2016), p. 1-9
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2016 ( 2016), p. 1-9
    Abstract: Root canal calcification is considered a great challenge during root canal treatment. Although the application of ultrasonic instruments and dental operating microscope (DOM) has advantages, dealing with calcified root canals still suffers a great risk of failure because of limited information about the location, length, and direction of obliteration on periapical radiographs. In this work, a cone-beam computed tomography- (CBCT-) aided method aimed at solving complicated calcified root canals in which conventional approaches could not work was proposed. Thirteen teeth with sixteen calcified canals (12 calcified in the upper third, 4 calcified in the middle third), which cannot be negotiated with conventional methods, were treated with the aid of CBCT. The location of calcification and depth of instrumentation and operating direction were calculated and assessed in three dimensions with ultrasonic instruments under DOM. In all thirteen teeth, canals with upper and middle thirds calcification were treated successfully. Finally, a guideline was proposed to help achieve consistent apical patency in calcified canals.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2016/4793146
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2698540-8
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  • 8
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    Online Resource
    Synthesis, Characterization and Antitumor Activity of a Series of Polypyridyl Complexes
    Hindawi Limited ; 2000
    In:  Metal-Based Drugs Vol. 7, No. 6 ( 2000-01-01), p. 343-348
    Details
    In: Metal-Based Drugs, Hindawi Limited, Vol. 7, No. 6 ( 2000-01-01), p. 343-348
    Abstract: A series of polypyridyl complexes have been synthesized. All polypyridyl complexes and some of the soluble ligands have been assayed for antitumor activity in vitro against the HL-60 (the human leucocytoma) cells, BEL-7402 (the human liver carcinoma) cells, KB (the human nasopharyngeal carcinoma) cells and HELA (the human adenocarcinoma of cervix) cells. The results indicate that several complexes have relative activity against different cell lines. Especially, the complexes [Co(bpy) 2 (pip)] 3+ , [Co(phen) 2 (pip)] 3+ , [Ru(bpy) 2 (pztp)] 2+ and [Ru(pztp) 2 (bpy)] 2+ show relative high activity against four tumor cell lines. Moreover, they are slightly more effective than cisplatin. At the concentration of 100 μg/mL, the complexes show inhibitory rate of 72∼86% for the cancer cells and have no toxicity for MDCK and Vero cells. It is indicated that these complexes can inhibit cancer cells selectively.
    Type of Medium: Online Resource
    ISSN: 0793-0291
    URL: Article
    DOI: 10.1155/MBD.2000.343
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2000
    detail.hit.zdb_id: 2392146-8
    SSG: 15,3
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  • 9
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    Online Resource
    Renin–angiotensin system blockade for the risk of cancer and death
    Hindawi Limited ; 2016
    In:  Journal of the Renin-Angiotensin-Aldosterone System Vol. 17, No. 3 ( 2016-07), p. 147032031665667-
    Details
    In: Journal of the Renin-Angiotensin-Aldosterone System, Hindawi Limited, Vol. 17, No. 3 ( 2016-07), p. 147032031665667-
    Abstract: The effects of renin–angiotensin system blockade with angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II type 1 receptor blockers (ARBs) on cancer remain inconsistent. Methods: We searched existing databases from 1960 to August 2015, for randomised controlled trials and observational studies (case–control studies and cohort studies) of ARB/ACEI therapy with a minimal one year of follow-up. Outcomes were incidence and mortality of cancer. Results: We included 14 randomised controlled trials and 17 observational studies of 3,957,725 participants (350,329 ARB/ACEI users). The users had a lower incidence of cancer in the observational studies (RR 0.82, 95% CI 0.73–0.93) but not in the randomised controlled trials (RR 1.00, 95% CI 0.92–1.08). The protection persisted for lung cancer (RR 0.85, 95% CI 0.75–0.97) but not for other sites of cancer. The relative risk of cancer associated with renin–angiotensin system blockade was reduced along with time of follow-up. Mortality reduction with ARB/ACEI was marginally significant in the observational studies (RR 0.71, 95% CI 0.55–0.93) but not in the randomised controlled trials (RR 0.99, 95% CI 0.89–1.09). Conclusions: The significant benefits of renin–angiotensin system blockade observed in case–control studies and cohort studies might diminish in randomised controlled trials. Clinical design, site of cancer and duration of follow-up may affect the clinical outcomes.
    Type of Medium: Online Resource
    ISSN: 1470-3203 , 1752-8976
    URL: Article
    DOI: 10.1177/1470320316656679
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2261873-9
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  • 10
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    The acquisition of an inheritable 50-bp deletion in the human mtDNA control region does not affect the mtDNA copy number in peripheral blood cells
    Hindawi Limited ; 2010
    In:  Human Mutation ( 2010), p. n/a-n/a
    Details
    In: Human Mutation, Hindawi Limited, ( 2010), p. n/a-n/a
    Type of Medium: Online Resource
    ISSN: 1059-7794 , 1098-1004
    URL: Article
    DOI: 10.1002/humu.21220
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2010
    detail.hit.zdb_id: 1498165-8
    SSG: 12
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