Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    In: Nutrients, MDPI AG, Vol. 14, No. 15 ( 2022-07-30), p. 3158-
    Abstract: Background: low vitamin D status has been associated with an increased incidence of cardiovascular events. However, whether vitamin D supplementation would reduce the incidence of cardiovascular events remains unclear. Purpose: To perform a systematic review and meta-analysis of the effect of vitamin D supplementation on the mortality and incidence of cardiovascular events. Data Sources: We searched Medline, Embase, and the Cochrane Central Register of Controlled Trials from their inception until 3 May 2022. Study Selection: Two authors searched for randomized clinical trials that reported vitamin D supplementation’s effect on cardiovascular events outcomes. Data Extraction: Two authors conducted independent data extraction. Data Synthesis: We identified 41,809 reports; after exclusions, 18 trials with a total of 70,278 participants were eligible for analysis. Vitamin D supplementation was not associated with the mortality of cardiovascular events (RR 0.96, 95% CI 0.88–1.06, I2 = 0%), the incidence of stroke (RR 1.05, 95% CI 0.92–1.20, I2 = 0%), myocardial infarction (RR 0.97, 95% CI 0.87–1.09, I2 = 0%), total cardiovascular events (RR 0.97, 95% CI 0.91–1.04, I2 = 27%), or cerebrovascular events (RR 1.01, 95% CI 0.87–1.18, I2 = 0%). Limitation: Cardiovascular events were the secondary outcome in most trials and thus, might be selectively reported. Conclusion: In this meta-analysis of randomized clinical trials, vitamin D supplementation was not associated with a lower risk of cardiovascular events than no supplementation. These findings do not support the routine use of vitamin D supplementation in general.
    Type of Medium: Online Resource
    ISSN: 2072-6643
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2518386-2
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Online Resource
    Online Resource
    MDPI AG ; 2016
    In:  International Journal of Molecular Sciences Vol. 17, No. 5 ( 2016-04-28), p. 624-
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 17, No. 5 ( 2016-04-28), p. 624-
    Type of Medium: Online Resource
    ISSN: 1422-0067
    Language: English
    Publisher: MDPI AG
    Publication Date: 2016
    detail.hit.zdb_id: 2019364-6
    SSG: 12
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 16, No. 3 ( 2015-03-02), p. 4628-4641
    Type of Medium: Online Resource
    ISSN: 1422-0067
    Language: English
    Publisher: MDPI AG
    Publication Date: 2015
    detail.hit.zdb_id: 2019364-6
    SSG: 12
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    Online Resource
    Online Resource
    MDPI AG ; 2015
    In:  International Journal of Molecular Sciences Vol. 17, No. 1 ( 2015-12-23), p. 19-
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 17, No. 1 ( 2015-12-23), p. 19-
    Type of Medium: Online Resource
    ISSN: 1422-0067
    Language: English
    Publisher: MDPI AG
    Publication Date: 2015
    detail.hit.zdb_id: 2019364-6
    SSG: 12
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    In: Nanomaterials, MDPI AG, Vol. 9, No. 12 ( 2019-12-11), p. 1760-
    Abstract: Lead-free double perovskites have been considered as a potential environmentally friendly photovoltaic material for substituting the hybrid lead halide perovskites due to their high stability and nontoxicity. Here, lead-free double perovskite Cs2AgBiBr6 films are initially fabricated by single-source evaporation deposition under high vacuum condition. X-ray diffraction and scanning electron microscopy characterization show that the high crystallinity, flat, and pinhole-free double perovskite Cs2AgBiBr6 films were obtained after post-annealing at 300 °C for 15 min. By changing the annealing temperature, annealing time, and film thickness, perovskite Cs2AgBiBr6 solar cells with planar heterojunction structure of FTO/TiO2/Cs2AgBiBr6/Spiro-OMeTAD/Ag achieve an encouraging power conversion efficiency of 0.70%. Our preliminary work opens a feasible approach for preparing high-quality double perovskite Cs2AgBiBr6 films wielding considerable potential for photovoltaic application.
    Type of Medium: Online Resource
    ISSN: 2079-4991
    Language: English
    Publisher: MDPI AG
    Publication Date: 2019
    detail.hit.zdb_id: 2662255-5
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 19, No. 11 ( 2018-10-31), p. 3419-
    Abstract: Hepatocellular cancer (HCC) is a lethal malignancy with poor prognosis and easy recurrence. There are few agents with minor toxic side effects that can be used for treatment of HCC. Evodiamine (Evo), one of the major bioactive components derived from fructus Evodiae, has long been shown to exert anti-hepatocellular carcinoma activity by suppressing activation of nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK). In addition, in the Nucleotide-Binding Oligomerization Domain 1 (NOD1) pathway, NOD1 could initiate NF-κB-dependent and MAPK-dependent gene transcription. Recent experimental studies reported that the NOD1 pathway was related to controlling development of various tumors. Here we hypothesize that Evo exerts anti-hepatocellular carcinoma activity by inhibiting NOD1 to suppress NF-κB and MAPK activation. Therefore, we proved the anti-hepatocellular carcinoma activity of Evo on HCC cells and detected the effect of Evo on the NOD1 pathway. We found that Evo significantly induced cell cycle arrest at the G2/M phase, upregulated P53 and Bcl-2 associated X proteins (Bax) proteins, and downregulated B-cell lymphoma-2 (Bcl-2), cyclinB1, and cdc2 proteins in HCC cells. In addition, Evo reduced levels of NOD1, p-P65, p-ERK, p-p38, and p-JNK, where the level of IκBα of HCC cells increased. Furthermore, NOD1 agonist γ-D-Glu-mDAP (IE-DAP) treatment weakened the effect of Evo on suppression of NF-κB and MAPK activation and cellular proliferation of HCC. In an in vivo subcutaneous xenograft model, Evo also exhibited excellent tumor inhibitory effects via the NOD1 signal pathway. Our results demonstrate that Evo could induce apoptosis remarkably and the inhibitory effect of Evo on HCC cells may be through suppressing the NOD1 signal pathway in vitro and in vivo.
    Type of Medium: Online Resource
    ISSN: 1422-0067
    Language: English
    Publisher: MDPI AG
    Publication Date: 2018
    detail.hit.zdb_id: 2019364-6
    SSG: 12
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    In: Sensors, MDPI AG, Vol. 19, No. 16 ( 2019-08-16), p. 3576-
    Abstract: The water and shadow areas in SAR images contain rich information for various applications, which cannot be extracted automatically and precisely at present. To handle this problem, a new framework called Multi-Resolution Dense Encoder and Decoder (MRDED) network is proposed, which integrates Convolutional Neural Network (CNN), Residual Network (ResNet), Dense Convolutional Network (DenseNet), Global Convolutional Network (GCN), and Convolutional Long Short-Term Memory (ConvLSTM). MRDED contains three parts: the Gray Level Gradient Co-occurrence Matrix (GLGCM), the Encoder network, and the Decoder network. GLGCM is used to extract low-level features, which are further processed by the Encoder. The Encoder network employs ResNet to extract features at different resolutions. There are two components of the Decoder network, namely, the Multi-level Features Extraction and Fusion (MFEF) and Score maps Fusion (SF). We implement two versions of MFEF, named MFEF1 and MFEF2, which generate separate score maps. The difference between them lies in that the Chained Residual Pooling (CRP) module is utilized in MFEF2, while ConvLSTM is adopted in MFEF1 to form the Improved Chained Residual Pooling (ICRP) module as the replacement. The two separate score maps generated by MFEF1 and MFEF2 are fused with different weights to produce the fused score map, which is further handled by the Softmax function to generate the final extraction results for water and shadow areas. To evaluate the proposed framework, MRDED is trained and tested with large SAR images. To further assess the classification performance, a total of eight different classification frameworks are compared with our proposed framework. MRDED outperformed by reaching 80.12% in Pixel Accuracy (PA) and 73.88% in Intersection of Union (IoU) for water, 88% in PA and 77.11% in IoU for shadow, and 95.16% in PA and 90.49% in IoU for background classification, respectively.
    Type of Medium: Online Resource
    ISSN: 1424-8220
    Language: English
    Publisher: MDPI AG
    Publication Date: 2019
    detail.hit.zdb_id: 2052857-7
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    In: Remote Sensing, MDPI AG, Vol. 12, No. 3 ( 2020-01-31), p. 441-
    Abstract: Bridge detection from Synthetic Aperture Radar (SAR) images has very important strategic significance and practical value, but there are still many challenges in end-to-end bridge detection. In this paper, a new deep learning-based network is proposed to identify bridges from SAR images, namely, multi-resolution attention and balance network (MABN). It mainly includes three parts, the attention and balanced feature pyramid (ABFP) network, the region proposal network (RPN), and the classification and regression. First, the ABFP network extracts various features from SAR images, which integrates the ResNeXt backbone network, balanced feature pyramid, and the attention mechanism. Second, extracted features are used by RPN to generate candidate boxes of different resolutions and fused. Furthermore, the candidate boxes are combined with the features extracted by the ABFP network through the region of interest (ROI) pooling strategy. Finally, the detection results of the bridges are produced by the classification and regression module. In addition, intersection over union (IOU) balanced sampling and balanced L1 loss functions are introduced for optimal training of the classification and regression network. In the experiment, TerraSAR data with 3-m resolution and Gaofen-3 data with 1-m resolution are used, and the results are compared with faster R-CNN and SSD. The proposed network has achieved the highest detection precision (P) and average precision (AP) among the three networks, as 0.877 and 0.896, respectively, with the recall rate (RR) as 0.917. Compared with the other two networks, the false alarm targets and missed targets of the proposed network in this paper are greatly reduced, so the precision is greatly improved.
    Type of Medium: Online Resource
    ISSN: 2072-4292
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2513863-7
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    Online Resource
    Online Resource
    MDPI AG ; 2020
    In:  Applied Sciences Vol. 10, No. 22 ( 2020-11-15), p. 8091-
    In: Applied Sciences, MDPI AG, Vol. 10, No. 22 ( 2020-11-15), p. 8091-
    Abstract: In this paper, the development and testing of a Roots pump with a new rotor profile for hydrogen recirculation in the fuel cell system are presented. The design method of the rotor profile, port position, and structure of the pump is presented. A prototype of a three-lobe Roots pump with helical rotors was fabricated, and its performance was experimentally tested. The measured data show that the effect of the pressure difference on the flow rate and volumetric efficiency of the Roots pump is the most significant, while the effect of suction pressure is limited. It is concluded that the leakage rather than flow resistance is the key factor, which has a major influence on volumetric and isentropic efficiency. The comparison of the performance is also given by the measured results of the same Roots pump working with air, helium, and hydrogen. Finally, the successful integration of the Roots pumps into three PEM fuel cell systems is reported and the optimal operating parameters of the Roots pump in the systems under various loads are also presented. It is found that the performance of the Roots pump integrated into the fuel cell system is better than that measured with pure hydrogen on the test rig. The performance maps composed of all the measured data of the Roots pump are very helpful for the optimal design and operation of the fuel cell system.
    Type of Medium: Online Resource
    ISSN: 2076-3417
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2704225-X
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    Online Resource
    Online Resource
    MDPI AG ; 2020
    In:  Remote Sensing Vol. 12, No. 19 ( 2020-10-01), p. 3205-
    In: Remote Sensing, MDPI AG, Vol. 12, No. 19 ( 2020-10-01), p. 3205-
    Abstract: Water detection from Synthetic Aperture Radar (SAR) images has been widely utilized in various applications. However, it remains an open challenge due to the high similarity between water and shadow in SAR images. To address this challenge, a new end-to-end framework based on deep learning has been proposed to automatically classify water and shadow areas in SAR images. This end-to-end framework is mainly composed of three parts, namely, Multi-scale Spatial Feature (MSF) extraction, Multi-Level Selective Attention Network (MLSAN) and the Improvement Strategy (IS). Firstly, the dataset is input to MSF for multi-scale low-level feature extraction via three different methods. Then, these low-level features are fed into the MLSAN network, which contains the Encoder and Decoder. The Encoder aims to generate different levels of features using residual network of 101 layers. The Decoder extracts geospatial contextual information and fuses the multi-level features to generate high-level features that are further optimized by the IS. Finally, the classification is implemented with the Softmax function. We name the proposed framework as MSF-MLSAN, which is trained and tested using millimeter wave SAR datasets. The classification accuracy reaches 0.8382 and 0.9278 for water and shadow, respectively; while the overall Intersection over Union (IoU) is 0.9076. MSF-MLSAN demonstrates the success of integrating SAR domain knowledge and state-of-the-art deep learning techniques.
    Type of Medium: Online Resource
    ISSN: 2072-4292
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2513863-7
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. Further information can be found on the KOBV privacy pages