In:
Menopause, Ovid Technologies (Wolters Kluwer Health), Vol. 26, No. 6 ( 2019-06), p. 670-676
Abstract:
The evidence between age at menarche and mortality risk is controversial. We aimed to quantify the dose–response association of age at menarche and risk of all-cause and cardiovascular disease (CVD) mortality based on cohort studies. Methods: PubMed, EMBASE, Web of Science, and Scopus databases were searched up to March 15, 2018 for relevant articles. Random-effects models and restricted cubic splines were used for this meta-analysis. Results: Twelve cohort studies, with 79,363 deaths and 2,341,769 participants, met the inclusion criteria. With each 1-year increase in menarche age, the relative risk (RR) was reduced for all-cause mortality (RR: 0.977, 95% confidence interval [CI]: 0.970-0.984), CVD mortality (RR: 0.993, 95% CI: 0.975-1.011), ischemic heart disease (IHD) mortality (RR: 0.969, 95% CI: 0.947-0.993), and stroke mortality (RR: 0.983, 95% CI: 0.954-1.012). We found a nonlinear dose–response association ( P nonlinearity = 0.001) between age at menarche and all-cause mortality, with the lowest risk observed at menarche age 15 years (RR: 0.849 95% CI: 0.800-0.901), but no evidence of a nonlinear association between menarche age and CVD mortality ( P nonlinearity = 0.543), IHD mortality ( P nonlinearity = 0.310), or stroke mortality ( P nonlinearity = 0.824). Conclusions: Age at menarche is inversely associated with all-cause and IHD mortality.
Type of Medium:
Online Resource
ISSN:
1072-3714
,
1530-0374
DOI:
10.1097/GME.0000000000001289
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2019
detail.hit.zdb_id:
2071114-1
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