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  • Oxford University Press (OUP)  (4)
  • 1
    Online Resource
    Online Resource
    Oxford University Press (OUP) ; 2015
    In:  Microscopy and Microanalysis Vol. 21, No. S3 ( 2015-08), p. 1007-1008
    In: Microscopy and Microanalysis, Oxford University Press (OUP), Vol. 21, No. S3 ( 2015-08), p. 1007-1008
    Type of Medium: Online Resource
    ISSN: 1431-9276 , 1435-8115
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2015
    detail.hit.zdb_id: 1481716-0
    SSG: 11
    SSG: 12
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  • 2
    Online Resource
    Online Resource
    Oxford University Press (OUP) ; 2022
    In:  European Journal of Orthodontics Vol. 44, No. 1 ( 2022-01-25), p. 1-10
    In: European Journal of Orthodontics, Oxford University Press (OUP), Vol. 44, No. 1 ( 2022-01-25), p. 1-10
    Abstract: Several orthognathic procedures have been applied to correct skeletal anterior open bites (SAOB). Which method is most stable has been debated and no consensus has been reached and there is no conclusive evidence for clinicians to use. Objective To analyse whether maxillary, mandibular, or bimaxillary surgery provides a better stability. Materials and methods A systematic search was conducted up to December 2020 using PubMed, EMBASE, Medline, Scopus, Web of Science, Cochrane CENTRAL, and Google Scholar. We made direct comparisons among the controlled trials and also made indirect comparisons via subgroup analysis on the aspects of occlusional, skeletal, and dento-alveolar stability to assess the overall stability of each method. Results Finally 16 cohort studies were identified. At the occlusional level, pooled change in overbite was 0.21 mm in maxillary surgery, 0.37 mm in bimaxillary surgery, and −0.32 mm in mandibular surgery. At the skeletal level, pooled sella–nasion–Point A angle (SNA) was −0.12 degrees in bimaxillary surgery, −0.37 degrees in maxillary surgery and −0.20 degrees in mandibular surgery. The sella–nasion to palatal plane angle (SNPP) relapsed to a statistically significant degree in all samples received single maxillary surgery. Relapse of the sella–nasion–Point B angle (SNB) was 0.47 degrees in mandibular setback, −1.8 degrees in mandibular advancement, and −0.48 degrees in maxillary surgery. The Sella–Nasion to mandibular plane angle (SNMP) relapsed more in procedures involving bilateral sagittal split osteotomy than in other procedures. As for dento-alveolar changes, intrusion of molars and extrusion of incisors took place in most patients. Conclusions Bimaxillary surgery produced the most beneficial post-operative increase in overbite, maxillary surgery led to a lesser but still positive overbite change, and mandibular surgery correlated with some extent of relapse. Skeletally, bimaxillary surgery was more stable than maxillary surgery at both SNA and SNPP; SNB was more stable in mandibular setback than advancement; and SNMP was unstable in both mandibular and bimaxillary surgeries versus maxillary surgery with comparable surgical changes. Dento-alveolar compensation helped maintain a positive overbite. Registration number CRD42020198088.
    Type of Medium: Online Resource
    ISSN: 0141-5387 , 1460-2210
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
    detail.hit.zdb_id: 1466699-6
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  • 3
    In: Stem Cells Translational Medicine, Oxford University Press (OUP), Vol. 5, No. 12 ( 2016-12-01), p. 1644-1655
    Abstract: Niemann-Pick disease type A (NPA) is a lysosomal storage disease caused by mutations in the SMPD1 gene that encodes acid sphingomyelinase (ASM). Deficiency in ASM function results in lysosomal accumulation of sphingomyelin and neurodegeneration. Currently, there is no effective treatment for NPA. To accelerate drug discovery for treatment of NPA, we generated induced pluripotent stem cells from two patient dermal fibroblast lines and differentiated them into neural stem cells. The NPA neural stem cells exhibit a disease phenotype of lysosomal sphingomyelin accumulation and enlarged lysosomes. By using this disease model, we also evaluated three compounds that reportedly reduced lysosomal lipid accumulation in Niemann-Pick disease type C as well as enzyme replacement therapy with ASM. We found that α-tocopherol, δ-tocopherol, hydroxypropyl-β-cyclodextrin, and ASM reduced sphingomyelin accumulation and enlarged lysosomes in NPA neural stem cells. Therefore, the NPA neural stem cells possess the characteristic NPA disease phenotype that can be ameliorated by tocopherols, cyclodextrin, and ASM. Our results demonstrate the efficacies of cyclodextrin and tocopherols in the NPA cell-based model. Our data also indicate that the NPA neural stem cells can be used as a new cell-based disease model for further study of disease pathophysiology and for high-throughput screening to identify new lead compounds for drug development. Significance Currently, there is no effective treatment for Niemann-Pick disease type A (NPA). To accelerate drug discovery for treatment of NPA, NPA-induced pluripotent stem cells were generated from patient dermal fibroblasts and differentiated into neural stem cells. By using the differentiated NPA neuronal cells as a cell-based disease model system, α-tocopherol, δ-tocopherol, and hydroxypropyl-β-cyclodextrin significantly reduced sphingomyelin accumulation in these NPA neuronal cells. Therefore, this cell-based NPA model can be used for further study of disease pathophysiology and for high-throughput screening of compound libraries to identify lead compounds for drug development.
    Type of Medium: Online Resource
    ISSN: 2157-6564 , 2157-6580
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2016
    detail.hit.zdb_id: 2642270-0
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  • 4
    Online Resource
    Online Resource
    Oxford University Press (OUP) ; 2019
    In:  Bioinformatics Vol. 35, No. 14 ( 2019-07-15), p. 2441-2448
    In: Bioinformatics, Oxford University Press (OUP), Vol. 35, No. 14 ( 2019-07-15), p. 2441-2448
    Abstract: Small P-values are often required to be accurately estimated in large-scale genomic studies for the adjustment of multiple hypothesis tests and the ranking of genomic features based on their statistical significance. For those complicated test statistics whose cumulative distribution functions are analytically intractable, existing methods usually do not work well with small P-values due to lack of accuracy or computational restrictions. We propose a general approach for accurately and efficiently estimating small P-values for a broad range of complicated test statistics based on the principle of the cross-entropy method and Markov chain Monte Carlo sampling techniques. Results We evaluate the performance of the proposed algorithm through simulations and demonstrate its application to three real-world examples in genomic studies. The results show that our approach can accurately evaluate small to extremely small P-values (e.g. 10-6 to 10-100). The proposed algorithm is helpful for the improvement of some existing test procedures and the development of new test procedures in genomic studies. Availability and implementation R programs for implementing the algorithm and reproducing the results are available at: https://github.com/shilab2017/MCMC-CE-codes. Supplementary information Supplementary data are available at Bioinformatics online.
    Type of Medium: Online Resource
    ISSN: 1367-4803 , 1367-4811
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2019
    detail.hit.zdb_id: 1468345-3
    SSG: 12
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