In:
PLOS ONE, Public Library of Science (PLoS), Vol. 18, No. 1 ( 2023-1-18), p. e0280359-
Abstract:
SGLT-2 inhibitor, traditionally used for glycemic control, has several beneficial effects that can help manage heart failure (HF). SGLT-2 inhibitors reduce the risk of cardiovascular mortality in patients with HF. As atrial fibrillation (AF) is closely associated with HF and diabetes mellitus (DM) is a risk factor for AF, we assume that SGLT-2 inhibitors will also show therapeutic benefits regarding AF, especially for rhythm control. This trial has a multicenter, prospective, open, blinded endpoint design. It is a 1:1 randomized and controlled study. A total of 716 patients who are newly diagnosed of AF and DM within 1 year will be enrolled from 7 tertiary medical centers. The trial is designed to compare the effects of SGLT-2 inhibitors and other oral hypoglycemic agents on atrial rhythm control in patients with AF and DM. The primary outcome is the recurrence of AF within a year (including post-antiarrhythmic drugs (AAD) or ablation). The secondary outcomes are the ablation rate within a year, change in AF burden, size of the left atrium, NT-proBNP, the AF symptom score, and the quality of life. This trial will prospectively evaluate the effect and safety of SGLT-2 inhibitors on AF rhythm control in patients with DM. It will provide an invaluable dataset on rhythm control in AF with DM for future studies and offer novel information to assist in clinical decisions. (BEYOND trial, ClinicalTrials.gov number: NCT05029115. https://clinicaltrials.gov/ct2/show/NCT05029115 ).
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0280359
DOI:
10.1371/journal.pone.0280359.g001
DOI:
10.1371/journal.pone.0280359.g002
DOI:
10.1371/journal.pone.0280359.t001
DOI:
10.1371/journal.pone.0280359.t002
DOI:
10.1371/journal.pone.0280359.t003
DOI:
10.1371/journal.pone.0280359.t004
DOI:
10.1371/journal.pone.0280359.t005
DOI:
10.1371/journal.pone.0280359.s001
DOI:
10.1371/journal.pone.0280359.s002
DOI:
10.1371/journal.pone.0280359.s003
DOI:
10.1371/journal.pone.0280359.s004
DOI:
10.1371/journal.pone.0280359.s005
DOI:
10.1371/journal.pone.0280359.s006
DOI:
10.1371/journal.pone.0280359.r001
DOI:
10.1371/journal.pone.0280359.r002
DOI:
10.1371/journal.pone.0280359.r003
DOI:
10.1371/journal.pone.0280359.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2267670-3
Bookmarklink