In:
PLOS ONE, Public Library of Science (PLoS), Vol. 18, No. 4 ( 2023-4-6), p. e0282221-
Abstract:
To investigate the diagnostic role of heart rate variability in breast cancer and its relationship with Carcinoembryonic antigen (CEA) in peripheral serum. Methods We reviewed the electronic medical records of patients who attended Zhujiang Hospital of Southern Medical University between October 2016 and May 2019. The patients were grouped based on breast cancer history and were divided into two groups: breast cancer group(n = 19) and control group(n = 18). All women were invited for risk factor screening, including 24-hour ambulatory ECG monitoring and blood biochemistry after admission. The difference and correlation between the breast cancer group and control group were performed by comparing the heart rate variability and serum CEA levels. Additionally, diagnostic efficacy analysis of breast cancer was calculated by combining heart rate variability and serum CEA. Results In total, 37 patients were eligible for analysis, with 19 and 18 patients in the breast cancer group and control groups, respectively. Women with breast cancer had a significantly lower level of total LF, awake TP, and awake LF, and a significantly higher level of serum CEA compared with women with no breast cancer. Total LF, awake TP, and awake LF were negatively correlated with the CEA index (P 〈 0.05). The receiver operating characteristic (ROC) curves indicated the highest area under the curve (AUC) scores and specificity of the combination of awake TP, awake LF, and serum CEA (P 〈 0.05), while sensitivity was highest for total LF, awake TP, and awake LF (P 〈 0.05). Conclusions Women with history of breast cancer had abnormalities in autonomic function. The combined analysis of heart rate variability and serum CEA analysis may have a predictive effect on the development of breast cancer and provide more basis for clinical diagnosis and treatment.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0282221
DOI:
10.1371/journal.pone.0282221.g001
DOI:
10.1371/journal.pone.0282221.g002
DOI:
10.1371/journal.pone.0282221.g003
DOI:
10.1371/journal.pone.0282221.g004
DOI:
10.1371/journal.pone.0282221.t001
DOI:
10.1371/journal.pone.0282221.t002
DOI:
10.1371/journal.pone.0282221.t003
DOI:
10.1371/journal.pone.0282221.s001
DOI:
10.1371/journal.pone.0282221.s002
DOI:
10.1371/journal.pone.0282221.s003
DOI:
10.1371/journal.pone.0282221.s004
DOI:
10.1371/journal.pone.0282221.s005
DOI:
10.1371/journal.pone.0282221.s006
DOI:
10.1371/journal.pone.0282221.s007
DOI:
10.1371/journal.pone.0282221.s008
DOI:
10.1371/journal.pone.0282221.r001
DOI:
10.1371/journal.pone.0282221.r002
DOI:
10.1371/journal.pone.0282221.r003
DOI:
10.1371/journal.pone.0282221.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2267670-3
Bookmarklink