In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 3 ( 2022-3-4), p. e0264854-
Abstract:
Myocardial infarction has a high mortality rate worldwide. Therefore, clinical intervention in cardiac remodeling after myocardial infarction is essential. Açai pulp is a natural product and has been considered a functional food because of its antioxidant/anti-inflammatory properties. The aim of the present study was to analyze the effect of açai pulp supplementation on cardiac remodeling after myocardial infarction in rats. After 7 days of surgery, male Wistar rats were assigned to six groups: sham animals fed standard chow (SA0, n = 14), fed standard chow with 2% açai pulp (SA2, n = 12) and fed standard chow with 5% açai pulp (SA5, n = 14), infarcted animals fed standard chow (IA0, n = 12), fed standard chow with 2% açai pulp (IA2, n = 12), and fed standard chow with 5% açai pulp (IA5, n = 12). After 3 months of supplementation, echocardiography and euthanasia were performed. Açai pulp supplementation, after myocardial infarction, improved energy metabolism, attenuated oxidative stress (lower concentration of malondialdehyde, P = 0.023; dose-dependent effect), modulated the inflammatory process (lower concentration of interleukin-10, P 〈 0.001; dose-dependent effect) and decreased the deposit of collagen (lower percentage of interstitial collagen fraction, P 〈 0.001; dose-dependent effect). In conclusion, açai pulp supplementation attenuated cardiac remodeling after myocardial infarction in rats. Also, different doses of açai pulp supplementation have dose-dependent effects on cardiac remodeling.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0264854
DOI:
10.1371/journal.pone.0264854.g001
DOI:
10.1371/journal.pone.0264854.g002
DOI:
10.1371/journal.pone.0264854.g003
DOI:
10.1371/journal.pone.0264854.g004
DOI:
10.1371/journal.pone.0264854.t001
DOI:
10.1371/journal.pone.0264854.t002
DOI:
10.1371/journal.pone.0264854.t003
DOI:
10.1371/journal.pone.0264854.t004
DOI:
10.1371/journal.pone.0264854.t005
DOI:
10.1371/journal.pone.0264854.t006
DOI:
10.1371/journal.pone.0264854.s001
DOI:
10.1371/journal.pone.0264854.s002
DOI:
10.1371/journal.pone.0264854.s003
DOI:
10.1371/journal.pone.0264854.s004
DOI:
10.1371/journal.pone.0264854.s005
DOI:
10.1371/journal.pone.0264854.r001
DOI:
10.1371/journal.pone.0264854.r002
DOI:
10.1371/journal.pone.0264854.r003
DOI:
10.1371/journal.pone.0264854.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
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