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  • 1
    Online Resource
    Online Resource
    Royal College of Psychiatrists ; 2013
    In:  British Journal of Psychiatry Vol. 203, No. 3 ( 2013-09), p. 188-195
    In: British Journal of Psychiatry, Royal College of Psychiatrists, Vol. 203, No. 3 ( 2013-09), p. 188-195
    Abstract: Adolescent substance use is associated with both earlier childhood behavioural problems and serious lifetime addiction problems later in life. Aims To examine whether, and through which mechanisms, targeting risk factors in early childhood prevents substance use across adolescence. Method Disruptive kindergarten boys ( n = 172) living in Montreal were randomly allocated to a preventive intervention and a control condition. The intervention was delivered over 2 years (7–9 years of age) with two main components: (a) social and problem-solving skills training for the boys; and (b) training for parents on effective child-rearing skills. Results Adolescent substance use, up to 8 years post-intervention, was reduced in those who received the intervention ( d = 0.48−0.70). Of most interest, the intervention effects were explained partly by reductions in impulsivity, antisocial behaviour and affiliation with less deviant peers during pre-adolescence (11–13 years). Conclusions Adolescent substance use may be indirectly prevented by selectively targeting childhood risk factors that disrupt the developmental cascade of adolescent risk factors for substance use.
    Type of Medium: Online Resource
    ISSN: 0007-1250 , 1472-1465
    RVK:
    Language: English
    Publisher: Royal College of Psychiatrists
    Publication Date: 2013
    detail.hit.zdb_id: 2021500-9
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  • 2
    In: The British Journal of Psychiatry, Royal College of Psychiatrists, Vol. 214, No. 3 ( 2019-03), p. 137-145
    Abstract: Heritability of antisocial behaviour is estimated at approximately 50% and involves multiple genes. Aims To investigate the cumulative genetic effects of 116 single nucleotide polymorphisms mapping to 11 candidate serotonergic genes and antisocial behaviours, in adolescence and in early adulthood. Method Participants were 410 male members of the Quebec Longitudinal Study of Kindergarten Children, a population-based cohort followed up prospectively from age 6 to age 23. The serotonergic genes were selected based on known physiological processes and prior associations with antisocial behaviours. Antisocial behaviours were self-reported and assessed by using semi-structured interviews in adolescence and in adulthood. Results Cumulative, haplotype-based contributions of serotonergic genes conferring risk and protection for antisocial behaviours were detected by using multilocus genetic profile risk scores (MGPRSs) and multilocus genetic profile protection scores (MGPPSs). Cumulatively, haplotype-based MGPRSs and MGPPSs contributed to 9.6, 8.5 and 15.2% of the variance in general delinquency in adolescence, property/violent crimes in early adulthood and physical partner violence in early adulthood, respectively. Conclusions This study extends previous research by showing a cumulative effect of multiple haplotypes conferring risk and protection to antisocial behaviours in adolescence and early adulthood. The findings further support the relevance of concomitantly considering multiple serotonergic polymorphisms to better understand the genetic aetiology of antisocial behaviours. Future studies should investigate the interplay between risk and protective haplotype-based multilocus genetic profile scores with the environment. Declaration of interest: I.O.-M. holds a Canada Research Chair in the developmental origins of vulnerability and resilience.
    Type of Medium: Online Resource
    ISSN: 0007-1250 , 1472-1465
    RVK:
    Language: English
    Publisher: Royal College of Psychiatrists
    Publication Date: 2019
    detail.hit.zdb_id: 2021500-9
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  • 3
    Online Resource
    Online Resource
    Royal College of Psychiatrists ; 2007
    In:  British Journal of Psychiatry Vol. 191, No. 5 ( 2007-11), p. 415-419
    In: British Journal of Psychiatry, Royal College of Psychiatrists, Vol. 191, No. 5 ( 2007-11), p. 415-419
    Abstract: Many intervention programmes have attempted to reduce disruptive behaviour problems during early childhood to prevent maladjustment during adolescence and adulthood. Aims To assess the long-term impact and clinical significance of a 2-year multicomponent preventive intervention on criminal behaviour and academic achievement, using intention-to-treat analyses. Method Targeted disruptive–aggressive boys considered to be at risk of later criminality and low school achievement (n =250), identified from a community sample (n =895), were randomly allocated to an intervention or a control group. The rest of the sample (n =645) served as the low-risk group. The intervention was multimodal and aimed at boys, parents and teachers. Official data measured both outcomes. Results Significantly more boys in the intervention group (13%; P 〈 0.05) completed high-school graduation and generally fewer (11%; P =0.06) had a criminal record compared with those allocated to the control group. Conclusions The results suggest that early preventive intervention for those at high risk of antisocial behaviour is likely to benefit both the individuals concerned and society.
    Type of Medium: Online Resource
    ISSN: 0007-1250 , 1472-1465
    RVK:
    Language: English
    Publisher: Royal College of Psychiatrists
    Publication Date: 2007
    detail.hit.zdb_id: 2021500-9
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  • 4
    In: The British Journal of Psychiatry, Royal College of Psychiatrists, Vol. 220, No. 2 ( 2022-02), p. 79-85
    Abstract: Youth who attempt suicide are more at risk for later mental disorders and suicide. However, little is known about their long-term socioeconomic outcomes. Aims We investigated associations between youth suicide attempts and adult economic and social outcomes. Method Participants were drawn from the Quebec Longitudinal Study of Kindergarten Children ( n = 2140) and followed up from ages 6 to 37 years. Lifetime suicide attempt was assessed at 15 and 22 years. Economic (employment earnings, retirement savings, welfare support, bankruptcy) and social (romantic partnership, separation/divorce, number of children) outcomes were assessed through data linkage with government tax return records obtained from age 22 to 37 years (2002–2017). Generalised linear models were used to test the association between youth suicide attempt and outcomes adjusting for background characteristics, parental mental disorders and suicide, and youth concurrent mental disorders. Results By age 22, 210 youths (9.8%) had attempted suicide. In fully adjusted models, youth who attempted suicide had lower annual earnings (average last 5 years, US$ −4134, 95% CI −7950 to −317), retirement savings (average last 5 years, US$ −1387, 95% CI −2982 to 209), greater risk of receiving welfare support (risk ratio (RR) = 2.05, 95% CI 1.39 to 3.04) and were less likely to be married/cohabiting (RR = 0.82, 95% CI 0.73 to 0.93), compared with those who did not attempt suicide. Over a 40-year working career, the loss of individual earnings attributable to suicide attempts was estimated at US$98 384. Conclusions Youth who attempt suicide are at risk of poor adult socioeconomic outcomes. Findings underscore the importance of psychosocial interventions for young people who have attempted suicide to prevent long-term social and economic disadvantage.
    Type of Medium: Online Resource
    ISSN: 0007-1250 , 1472-1465
    RVK:
    Language: English
    Publisher: Royal College of Psychiatrists
    Publication Date: 2022
    detail.hit.zdb_id: 2021500-9
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  • 5
    Online Resource
    Online Resource
    Royal College of Psychiatrists ; 2008
    In:  British Journal of Psychiatry Vol. 193, No. 2 ( 2008-08), p. 134-139
    In: British Journal of Psychiatry, Royal College of Psychiatrists, Vol. 193, No. 2 ( 2008-08), p. 134-139
    Abstract: Although childhood abuse is an important correlate of suicidality, not all individuals who were abused as children attempt suicide. Aims To identify correlates and moderators of suicide attempts in adults reporting childhood physical abuse, contact sexual abuse, or both. Method A French-Canadian, school-based cohort ( n =1684) was prospectively followed. Results The identity of the abuser moderated the relationship of abuse frequency and suicide attempts, with individuals abused by their immediate family being at highest risk. Although paternal education exhibited negative associations (OR=0.71, 95% CI 0.58–0.88), several externalising phenotypes had positive associations with suicide attempts: disruptive disorders (OR=3.10, 95% CI 1.05–9.15), conduct problems (OR=1.09, 95% CI 1.01–1.19) and childhood aggression (OR=1.41, 95% CI 1.08–1.83). Conclusions Characteristics of the abuser and abusive acts may be important additional indicators of risk for suicide attempts. Future research needs to employ developmental approaches to examine the extent and mechanisms by which childhood abuse contributes to the shared variance of suicidality, maladaptive traits and psychopathology.
    Type of Medium: Online Resource
    ISSN: 0007-1250 , 1472-1465
    RVK:
    Language: English
    Publisher: Royal College of Psychiatrists
    Publication Date: 2008
    detail.hit.zdb_id: 2021500-9
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  • 6
    Online Resource
    Online Resource
    Royal College of Psychiatrists ; 2016
    In:  British Journal of Psychiatry Vol. 208, No. 1 ( 2016-01), p. 42-48
    In: British Journal of Psychiatry, Royal College of Psychiatrists, Vol. 208, No. 1 ( 2016-01), p. 42-48
    Abstract: The monoamine oxidase A ( MAOA ) gene has been shown to moderate the impact of maltreatment on antisocial behaviour. Replication efforts have, however, yielded inconsistent results. Aims To investigate whether the interaction between the MAOA gene and violence is present across the full distribution of violence or emerges at higher levels of exposure. Method Participants were 327 male members of the Québec Longitudinal Study of Kindergarten Children. Exposure to violence comprised retrospective reports of mother's and father's maltreatment, sexual and physical abuse. Conduct disorder and antisocial personality symptoms were assessed in semi-structured interviews and partner violence, property-violent crimes and arrest were self-reported. Results Non-linear interactions between the MAOA gene and violence were detected, suggesting that the genetic moderation may come about once a certain level of violence is experienced. Conclusions Future studies should investigate the mechanisms translating substantial violence exposure, which could, subsequently, trigger the expression of genetically based differences in antisocial behaviour.
    Type of Medium: Online Resource
    ISSN: 0007-1250 , 1472-1465
    RVK:
    Language: English
    Publisher: Royal College of Psychiatrists
    Publication Date: 2016
    detail.hit.zdb_id: 2021500-9
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