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  • 1
    Online Resource
    Online Resource
    Topical Tacrolimus as a Therapeutic Adjunct in Patients with Cutaneous Lupus erythematosus
    S. Karger AG ; 2003
    In:  Dermatology Vol. 207, No. 4 ( 2003), p. 381-385
    Details
    In: Dermatology, S. Karger AG, Vol. 207, No. 4 ( 2003), p. 381-385
    Abstract: The topical therapy of cutaneous lupus erythematosus (LE) consists mainly of corticosteroids which may lead to significant side effects when overused. We report the efficacy of topical tacrolimus as a therapeutic adjunct in 3 patients with cutaneous LE of the face. All patients, 1 with systemic LE and a malar rash, 1 with annular subacute cutaneous LE, the other with a papular variant of subacute cutaneous LE, experienced significant improvement following application of tacrolimus ointment. Treatment with topical tacrolimus was tolerated well without major side effects in all patients. The presented cases are in line with recent reports that topical tacrolimus may be effective in facial LE.
    Type of Medium: Online Resource
    ISSN: 1018-8665 , 1421-9832
    URL: Article
    DOI: 10.1159/000074119
    RVK:
    XA 37700
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2003
    detail.hit.zdb_id: 1482189-8
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  • 2
    Online Resource
    Online Resource
    Cell Surface Membrane Antigen Phenotype of Human Gastrointestinal Mast Cells
    S. Karger AG ; 2005
    In:  International Archives of Allergy and Immunology Vol. 138, No. 2 ( 2005), p. 111-120
    Details
    In: International Archives of Allergy and Immunology, S. Karger AG, Vol. 138, No. 2 ( 2005), p. 111-120
    Abstract: 〈 i 〉 Background: 〈 /i 〉 Mast cells (MC) are important effector cells of allergic and inflammatory reactions in diverse organs. These cells interact with a number of other immune cells and structural cells in the tissues as well as with proinflammatory mediators and cytokines. The various interactions are considered to be mediated through distinct cell surface membrane receptors on MC. 〈 i 〉 Methods: 〈 /i 〉 In the present study, we have established the cell surface membrane phenotype of human gastrointestinal MC (HGMC) using a panel of monoclonal antibodies and indirect immunofluorescence staining techniques. 〈 i 〉 Results: 〈 /i 〉 HGMC were found to react with antibodies against CD29, CD33, CD44, CD45, CD47, CD54, CD55, CD58, CD63, CD117, CD147, CD151, CD172a, and CD203c. By contrast, HGMC did not express detectable amounts of CD1, CD2, CD4, CD5, CD14, CD15, CD16, CD22, CD24, CD25, CD26, CD27, CD28, CD31, CD32, CD34, CD35, CD88, or CD116. The α-chain of the IL-3 receptor (CD123) was detectable neither in resting HGMC nor in HGMC exposed to stem cell factor and interleukin-4. 〈 i 〉 Conclusions: 〈 /i 〉 HGMC express a unique profile of surface antigens including the receptor for mast cell growth factor, adhesion-related molecules, and activation-linked membrane antigens.
    Type of Medium: Online Resource
    ISSN: 1018-2438 , 1423-0097
    URL: Article
    DOI: 10.1159/000088432
    RVK:
    XA 49650
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2005
    detail.hit.zdb_id: 1482722-0
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  • 3
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    Online Resource
    Long-Term Efficacy of Occlusive Therapy with Topical Pimecrolimus in Severe Dyshidrosiform Hand and Foot Eczema
    S. Karger AG ; 2007
    In:  Dermatology Vol. 214, No. 1 ( 2007), p. 99-100
    Details
    In: Dermatology, S. Karger AG, Vol. 214, No. 1 ( 2007), p. 99-100
    Type of Medium: Online Resource
    ISSN: 1018-8665 , 1421-9832
    URL: Article
    DOI: 10.1159/000096923
    RVK:
    XA 37700
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2007
    detail.hit.zdb_id: 1482189-8
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  • 4
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    Online Resource
    Heart Rate Reduction by Ivabradine Improves Aortic Compliance in Apolipoprotein E-Deficient Mice
    S. Karger AG ; 2012
    In:  Journal of Vascular Research Vol. 49, No. 5 ( 2012), p. 432-440
    Details
    In: Journal of Vascular Research, S. Karger AG, Vol. 49, No. 5 ( 2012), p. 432-440
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Impaired vascular compliance is associated with cardiovascular mortality. The effects of heart rate on vascular compliance are unclear. Therefore, we characterized effects of heart rate reduction (HRR) by I( 〈 i 〉 f 〈 /i 〉 ) current inhibition on aortic compliance and underlying molecular mechanisms in apolipoprotein E-deficient (ApoE 〈 sup 〉 – 〈 /sup 〉 / 〈 sup 〉 – 〈 /sup 〉 ) mice. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 ApoE 〈 sup 〉 – 〈 /sup 〉 / 〈 sup 〉 – 〈 /sup 〉 mice fed a high-cholesterol diet and wild-type (WT) mice were treated with ivabradine (20 mg/kg/d) or vehicle for 6 weeks. Compliance of the ascending aorta was evaluated by MRI. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Ivabradine reduced heart rate by 113 ± 31 bpm (∼19%) in WT mice and by 133 ± 6 bpm (∼23%) in ApoE 〈 sup 〉 – 〈 /sup 〉 / 〈 sup 〉 – 〈 /sup 〉 mice. Compared to WT controls, ApoE 〈 sup 〉 – 〈 /sup 〉 / 〈 sup 〉 – 〈 /sup 〉 mice exhibited reduced distensibility and circumferential strain. HRR by ivabradine increased distensibility and circumferential strain in ApoE 〈 sup 〉 – 〈 /sup 〉 / 〈 sup 〉 – 〈 /sup 〉 mice but did not affect both parameters in WT mice. Ivabradine reduced aortic protein and mRNA expression of the angiotensin II type 1 (AT1) receptor and reduced rac1-GTPase activity in ApoE 〈 sup 〉 – 〈 /sup 〉 / 〈 sup 〉 – 〈 /sup 〉 mice. Moreover, membrane translocation of p47 〈 sup 〉 phox 〈 /sup 〉 was inhibited. In ApoE 〈 sup 〉 – 〈 /sup 〉 / 〈 sup 〉 – 〈 /sup 〉 mice, HRR induced anti-inflammatory effects by reduction of aortic mRNA expression of IL-6, TNF-alpha and TGF-beta. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 HRR by ivabradine improves vascular compliance in ApoE 〈 sup 〉 – 〈 /sup 〉 / 〈 sup 〉 – 〈 /sup 〉 mice. Contributing mechanisms include downregulation of the AT1 receptor, attenuation of oxidative stress and modulation of inflammatory cytokine expression.
    Type of Medium: Online Resource
    ISSN: 1018-1172 , 1423-0135
    URL: Article
    DOI: 10.1159/000339547
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2012
    detail.hit.zdb_id: 1482726-8
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  • 5
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    Online Resource
    The Role of Melanocortins in Skin Homeostasis
    S. Karger AG ; 2000
    In:  Hormone Research in Paediatrics Vol. 54, No. 5-6 ( 2000), p. 287-293
    Details
    In: Hormone Research in Paediatrics, S. Karger AG, Vol. 54, No. 5-6 ( 2000), p. 287-293
    Abstract: Melanocortins are structurally related bioactive peptides which are produced by many extra-neural tissues including the skin. All of the melanocortins (α, β, and γ-melanocyte-stimulating hormone and adrenocorticotropin) have melanotropic activity but can elicit many other effects on skin cells. On the basis of in vitro and in vivo findings melanocortins have been shown to regulate immune and inflammatory responses, hair growth, exocrine gland activity and extracellular matrix composition. These effects are mediated by melanocortin receptors among which the melanocortin-1 receptor is most ubiquitously expressed by human skin cells. Simultaneous expression of melanocortins and their receptors suggest a complex autocrine and/or paracrine regulatory network whose disruption invariably affects skin homeostasis. Expression of melanocortin receptors on various skin cell types further indicates novel pharmacological targets for the treatment of skin diseases.
    Type of Medium: Online Resource
    ISSN: 1663-2818 , 1663-2826
    URL: Article
    DOI: 10.1159/000053273
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2000
    detail.hit.zdb_id: 2540224-9
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  • 6
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    Online Resource
    Differences in Patient Characteristics Among Men Choosing Open or Robot-Assisted Radical Prostatectomy in Contemporary Practice at a European High-Volume Center
    S. Karger AG ; 2016
    In:  Urologia Internationalis Vol. 97, No. 1 ( 2016), p. 8-15
    Details
    In: Urologia Internationalis, S. Karger AG, Vol. 97, No. 1 ( 2016), p. 8-15
    Abstract: 〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 To examine the characteristics of robot-assisted radical prostatectomy (RARP) and open radical prostatectomy (ORP) patients at a high-volume center. 〈 b 〉 〈 i 〉 Patients and Methods: 〈 /i 〉 〈 /b 〉 We relied on the Martini-Clinic database and focused on prostate cancer patients treated in 2013. Characteristics in ORP and RARP patients were assessed. In multivariable logistic regression analyses (MVA), we predicted RARP treatment. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Of 1,920 patients, 575 (29.9%) underwent RARP and 1,345 (70.1%) ORP. RARP patients had a lower prostate-specific antigen (PSA), and were less likely to harbor pT3b, pathological Gleason ≥4 + 4 or lymph node metastases (all p 〈 0.05). Pelvic lymph node dissection (PLND) (84.3 vs. 87.0%, p = 0.1), as well as positive surgical margins (15.5 vs. 15.7%, p = 0.7) and the nerve-sparing status (p = 0.5) were comparable between RARP and ORP. Lymph node yield (median 11 vs. 16), and median blood loss (250 vs. 700 ml) were lower at RARP (all p 〈 0.001). Additionally, the median operating room time was higher at RARP (215 vs. 185 min, p 〈 0.001). In MVA, patients with body mass index (BMI) ≥30 were more likely to undergo RARP (OR 1.8, 95% CI 1.3-2.4, p 〈 0.001). Conversely, patients with PSA 〉 20 ng/ml were less likely to undergo RARP (OR 0.6, 95% CI 0.4-1.0, p = 0.03). 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 More favorable pathological characteristics were recorded at RARP. High BMI and low PSA were independent predictors for RARP. Treatment characteristics such as PLND rates, margin status and nerve sparing were comparable between RARP and ORP. Despite lower blood loss at RARP, a longer operating room time and lower yield of lymph nodes were recorded.
    Type of Medium: Online Resource
    ISSN: 0042-1138 , 1423-0399
    URL: Article
    DOI: 10.1159/000443701
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2016
    detail.hit.zdb_id: 1464417-4
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  • 7
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    Online Resource
    Expression of the α7 Nicotinic Acetylcholine Receptor Is Critically Required for the Antifibrotic Effect of PHA-543613 on Skin Fibrosis
    S. Karger AG ; 2022
    In:  Neuroendocrinology Vol. 112, No. 5 ( 2022), p. 446-456
    Details
    In: Neuroendocrinology, S. Karger AG, Vol. 112, No. 5 ( 2022), p. 446-456
    Abstract: 〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 Targeting the α7 nicotinic acetylcholine receptor (α7nAChR) has recently been suggested as a potential new treatment for fibrotic skin diseases. Here, we performed a genetic and pharmacologic approach to clarify the role of this receptor in the bleomycin (BLM) mouse model of skin fibrosis using α7nAChR KO mice. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 We analyzed the expression of extracellular matrix (ECM) components in murine skin using quantitative RT-PCR, pepsin digestion/SDS-PAGE of proteins and performed hydroxyproline assays as well as histological/immunohistochemical staining of skin sections. To identity the target cells of the α7nAChR agonist PHA-543613, we used murine dermal fibroblasts (MDF). We tested their response to the profibrotic cytokine transforming growth factor-β 〈 sub 〉 1 〈 /sub 〉 (TGF-β 〈 sub 〉 1 〈 /sub 〉 ) and utilized gene silencing to elucidate the role of the α7nAChR. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 We confirmed our previous findings on C3H/HeJ mice and detected a suppressive effect of PHA-543613 on BLM-induced skin fibrosis in the mouse strain C57BL/6J. This antifibrotic effect of PHA-543613 was abrogated in α7nAChR-KO mice. Interestingly, α7nAChR-KO animals exhibited a basal profibrotic signature by higher RNA expression of ECM genes and hydroxyproline content than WT mice. In WT MDF, PHA-543613 suppressed ECM gene expression induced by TGF-β 〈 sub 〉 1 〈 /sub 〉 . Gene silencing of α7nAChR by small interfering RNA neutralized the effects of PHA-543613 on TGF-β 〈 sub 〉 1 〈 /sub 〉 -mediated ECM gene expression. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 In summary, we have identified the α7nAChR as the essential mediator of the antifibrotic effect of PHA-543613. MDF are directly targeted by PHA-543613 to suppress collagen synthesis. Our findings emphasize therapeutic exploitation of α7nAChR receptor agonists in fibrotic skin diseases.
    Type of Medium: Online Resource
    ISSN: 0028-3835 , 1423-0194
    URL: Article
    DOI: 10.1159/000517772
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2022
    detail.hit.zdb_id: 1483028-0
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  • 8
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    Online Resource
    Disseminated Giant Molluscum Contagiosum in a Patient with Idiopathic CD4+ Lymphocytopenia
    S. Karger AG ; 2008
    In:  Dermatology Vol. 217, No. 3 ( 2008), p. 196-198
    Details
    In: Dermatology, S. Karger AG, Vol. 217, No. 3 ( 2008), p. 196-198
    Abstract: Idiopathic CD4+ lymphocytopenia is a rare disease without HIV infection or any other underlying immunodeficiency. Patients with this condition are predisposed to various opportunistic infections. We describe a 31-year-old woman with giant molluscum contagiosum disseminated over nearly the whole body. Immunologic analysis disclosed very low numbers of CD4+ lymphocytes ( 〈 11/µl, normal range: 240–3,100), an abnormal proliferative response of the patient’s lymphocytes to artificial mitogens and specific antigens, and an anergic delayed-type hypersensitivity skin response. HIV serology was repetitively negative. The diagnosis of idiopathic CD4+ lymphocytopenia was established. Systemic treatment with pegylated interferon-α2b (50 µg/week) for 16 months resulted in complete eradication of her disseminated giant molluscum contagiosum. In this report we will further describe the nature of idiopathic CD4+ lymphocytopenia and emphasize its relevance to clinical dermatology.
    Type of Medium: Online Resource
    ISSN: 1018-8665 , 1421-9832
    URL: Article
    DOI: 10.1159/000141649
    RVK:
    XA 37700
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2008
    detail.hit.zdb_id: 1482189-8
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  • 9
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    Online Resource
    Prediction of Significant Prostate Cancer at Prostate Biopsy and Per Core Detection Rate of Targeted and Systematic Biopsies Using Real-Time Shear Wave Elastography
    S. Karger AG ; 2015
    In:  Urologia Internationalis Vol. 95, No. 2 ( 2015), p. 189-196
    Details
    In: Urologia Internationalis, S. Karger AG, Vol. 95, No. 2 ( 2015), p. 189-196
    Abstract: 〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 Prostate cancer (PCa) detection is accompanied by overdiagnosis and mischaracterization of PCa. Therefore, new imaging modalities like shear wave elastography (SWE) are required. 〈 b 〉 〈 i 〉 Aim: 〈 /i 〉 〈 /b 〉 The aim of this study was to evaluate per-core detection rates (DRs) of targeted biopsies and systematic biopsies and to test if SWE findings can predict presence of clinically significant PCa (csPCa) at biopsy. 〈 b 〉 〈 i 〉 Patients and Methods: 〈 /i 〉 〈 /b 〉 Overall, 95 patients scheduled for prostate biopsy in our center underwent SWE. SWE findings were classified into suspicious or normal. Targeted biopsies were taken in up to 3 SWE-suspicious areas. csPCa was defined as the presence of Gleason pattern ≥4, level of prostate-specific antigen ≥10 ng/ml or 〉 2 positive cores. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Overall DR for csPCa in our study cohort was 40%. Per-core DR for exclusively SWE-targeted cores versus systematic samples cores was 10.5 vs. 8.6% (p = 0.3). In the logistic regression models, individuals with suspicious SWE findings are at 6.4-fold higher risk of harboring csPCa (p = 0.03). Gain in predictive accuracy was 2.3% (0.82 vs. 0.84, p = 0.01). 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Presence of suspicious SWE findings is an independent predictor of csPCa. Therefore, SWE may be helpful in selecting patients for biopsy. Nonetheless, per-core DR for SWE-targeted cores was not statistically significant higher than DR of systematic sampled cores. Therefore, additional systematic biopsy is mandatory.
    Type of Medium: Online Resource
    ISSN: 0042-1138 , 1423-0399
    URL: Article
    DOI: 10.1159/000431233
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2015
    detail.hit.zdb_id: 1464417-4
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