In:
Acta Haematologica, S. Karger AG, Vol. 137, No. 3 ( 2017), p. 163-172
Abstract:
Within this retrospective single-center study, we analyzed the survival of 320 multiple myeloma (MM) patients receiving melphalan high-dose chemotherapy (HDCT) and either single ( 〈 i 〉 n 〈 /i 〉 = 286) or tandem ( 〈 i 〉 n 〈 /i 〉 = 34) autologous stem cell transplantation (ASCT) from 1996 to 2012. Additionally, the impact of novel induction regimens was assessed. Median follow-up was 67 months, median overall survival (OS) 62 months, median progression-free survival (PFS) 33 months (95% CI 27-39), and treatment-related death (TRD) 3%. Multivariate analysis revealed age ≥60 years ( 〈 i 〉 p = 〈 /i 〉 0.03) and stage 3 according to the International Staging System ( 〈 i 〉 p = 〈 /i 〉 0.006) as adverse risk factors regarding PFS. Median OS was significantly better in newly diagnosed MM patients receiving induction therapy with novel agents, e.g., bortezomib, thalidomide, or lenalidomide, compared with a traditional regimen (69 vs. 58 months; 〈 i 〉 p = 〈 /i 〉 0.01). More patients achieved at least a very good partial remission in the period from 2005 to 2012 than from 1996 to 2004 (65 vs. 30%; 〈 i 〉 p 〈 /i 〉 〈 0.001), with a longer median OS in the later period (71 vs. 52 months, 〈 i 〉 p 〈 /i 〉 = 0.027). In conclusion, our analysis confirms HDCT-ASCT as an effective therapeutic strategy in an unselected large myeloma patient cohort with a low TRD rate and improved prognosis due to novel induction strategies.
Type of Medium:
Online Resource
ISSN:
0001-5792
,
1421-9662
Language:
English
Publisher:
S. Karger AG
Publication Date:
2017
detail.hit.zdb_id:
1481888-7
detail.hit.zdb_id:
80008-9
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