In:
American Journal of Nephrology, S. Karger AG, Vol. 36, No. 5 ( 2012), p. 444-450
Abstract:
〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 The aim of this study was to explore the associations between the prevalence of chronic kidney disease (CKD) and polymorphisms in the genes encoding matrix metalloproteinases (MMPs) and tissue inhibitor of matrix metalloproteinases (TIMPs). MMPs degrade extracellular matrix proteins in the glomerulus, and play important roles in kidney disease progression. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 DNA samples from 3,309 subjects aged 35–69 years were genotyped for 10 potentially functional polymorphisms in 〈 i 〉 MMP 〈 /i 〉 and 〈 i 〉 TIMP 〈 /i 〉 genes. The prevalence of CKD (estimated glomerular filtration rate 〈 60 ml/min/1.73 m 〈 sup 〉 2 〈 /sup 〉 ) was compared among the genotypes. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The prevalence of CKD decreased significantly with the number of minor alleles in 〈 i 〉 MMP9 〈 /i 〉 C–1562T (odds ratios (ORs) 0.77 for CT and 0.65 for TT compared with CC; p for trend = 0.023) and 〈 i 〉 MMP9 〈 /i 〉 R668Q (ORs, 0.79 for RQ and 0.64 for QQ compared with RR; p for trend = 0.024). The haplotype 〈 i 〉 MMP9 〈 /i 〉 –1562T/279R/668Q showed a reduced risk for CKD compared with the most common –1562C/279R/668R (OR 0.77, p = 0.008), and the genotype combination –1562TT/ 279RR/668QQ showed a halved risk for CKD compared with major allele homozygous –1562CC/279RR/668RR (OR 0.53, p = 0.091). 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 The potentially functional polymorphisms of 〈 i 〉 MMP9 〈 /i 〉 were associated with the prevalence of CKD in a large Japanese population. These genotypes have been reported to increase 〈 i 〉 MMP9 〈 /i 〉 expression, supporting the hypothesis that MMP-9 has a protective role in the progression of kidney diseases.
Type of Medium:
Online Resource
ISSN:
0250-8095
,
1421-9670
Language:
English
Publisher:
S. Karger AG
Publication Date:
2012
detail.hit.zdb_id:
1468523-1
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