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  • 1
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    Online Resource
    A Prospective Multicenter Study on the Prevalence of Fructose Malabsorption in Patients with Chronic Inflammatory Bowel Disease
    S. Karger AG ; 2021
    In:  Digestion Vol. 102, No. 3 ( 2021), p. 397-403
    Details
    In: Digestion, S. Karger AG, Vol. 102, No. 3 ( 2021), p. 397-403
    Abstract: Background and Aims: Patients with chronic inflammatory bowel disease (IBD) might have a higher prevalence of fructose malabsorption than healthy controls. This study’s aim was to determine the prevalence and symptom severity of fructose malabsorption in patients with active and inactive IBD. Methods: The present study was a multicenter noninterventional diagnostic pilot trial. Two hundred fifty-one participants were recruited from 12 outpatient clinics for internal medicine across Germany and from the University of Kiel. Fructose malabsorption was diagnosed by hydrogen breath testing. Patients diagnosed with bacterial overgrowth, non-H2 producers, and patients who were tested positive for lactose malabsorption were excluded. Gastrointestinal symptoms during breath testing were evaluated using four-point subjective items to determine severity of bloating, abdominal pain, and diarrhea. Results: Two hundred five patients (45 with active IBD, 80 with IBD in remission, and 81 healthy controls) were analyzed. The number of patients diagnosed with fructose malabsorption – 35/44 (79.6%) in patients with active IBD, 59/80 (73.8%) inactive IBD, and 66/81 (81.5%) in healthy controls – did not differ between the groups (χ2 [2, N = 205] = 1.48, p = 0.48). However, abdominal pain was more frequent in patients with active IBD than patients with IBD in remission (z = −2.936, p = 0.010), and diarrhea was more frequent in patients with active IBD than in healthy controls (z = 2.489, p = 0.038). Conclusions: Fructose malabsorption is not more common among patients with IBD than healthy subjects. However, the greater prevalence of patient-reported symptoms among patients with IBD may be of pathological and therapeutic relevance.
    Type of Medium: Online Resource
    ISSN: 0012-2823 , 1421-9867
    URL: Article
    DOI: 10.1159/000507851
    RVK:
    XA 40650
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2021
    detail.hit.zdb_id: 1482218-0
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  • 2
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    Online Resource
    Phytotherapie in den medizinischen S3-Leitlinien der Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften - eine systematische Übersichtsarbeit
    S. Karger AG ; 2014
    In:  Complementary Medicine Research Vol. 21, No. 6 ( 2014), p. 388-400
    Details
    In: Complementary Medicine Research, S. Karger AG, Vol. 21, No. 6 ( 2014), p. 388-400
    Abstract: 〈 i 〉 Phytotherapy in the German Medical AWMF S3 Guidelines - a Systematic Overview 〈 /i 〉 In Deutschland werden an die interdisziplinär, evidenz- und konsensbasiert erstellten S3-Leitlinien der Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF) höchste wissenschaftliche Ansprüche gestellt; sie prägen die Gestaltung der Patientenversorgung. Phytotherapeutika haben in der medizinischen Versorgung im deutschsprachigen Raum eine große Tradition. Zunehmend existiert Evidenz für ihre Wirksamkeit bei verschiedenen Erkrankungen. Die vorliegende Übersichtsarbeit untersucht, in welchem Ausmaß pflanzliche Arzneimittel in den aktuellen S3-Leitlinien Berücksichtigung finden. Mittels Überprüfung aller verfügbaren S3-Leitlinien der AWMF wurden die Empfehlungen/Statements zu phytotherapeutischen Therapieoptionen von 2 unabhängigen Experten identifiziert und in 3 Kategorien eingeteilt: positive, negative und offene. Darüber hinaus wurden Ausführungen zu Nebenwirkungen und Interaktionen recherchiert. In 40 (31,3%) der 128 Leitlinien wird Phytotherapie benannt. In 55 Leitlinien (42,9%), in denen grundsätzlich phytotherapeutische Therapieoptionen bestehen, werden pflanzlichen Arzneimittel nicht berücksichtigt. Von insgesamt 204 Empfehlungen zu Phytotherapeutika fallen 139 (68,1%) negativ aus oder bleiben ergebnisoffen. Phytotherapie wird in 27 Leitlinien (67,5%) im jeweiligen Kapitel zu komplementären und alternativen Verfahren und/oder unter Sonstiges eingeordnet, in 7 Leitlinien (17,5%) steht sie am Ende der Empfehlungen zur medikamentösen Therapie, in 8 Leitlinien (20%) zwischen den Empfehlungen zu konventionellen Verfahren. Hinweise zu Neben- und Wechselwirkungen finden sich zu 70 der 204 Empfehlungen (34,3%). Weit weniger als die Hälfte der verfügbaren AWMF-S3-Leitlinien beinhalten eine Recherche zu Phytotherapeutika, nur in 17 S3-Leitlinien finden sich aktuell positive Empfehlungen. Eine systematische Aufarbeitung der vorhandenen Evidenz ist notwendig, um die adäquate Berücksichtigung der Phytotherapie in den medizinischen Leitlinien zu gewährleisten.
    Type of Medium: Online Resource
    ISSN: 2504-2092 , 2504-2106
    URL: Article
    DOI: 10.1159/000370079
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2014
    detail.hit.zdb_id: 2888724-4
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  • 3
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    Online Resource
    Leitlinienarbeit im Bereich Naturheilkunde und Komplementärmedizin - das Potenzial ist noch lange nicht erschöpft
    S. Karger AG ; 2016
    In:  Forschende Komplementärmedizin / Research in Complementary Medicine Vol. 23, No. 3 ( 2016), p. 145-146
    Details
    In: Forschende Komplementärmedizin / Research in Complementary Medicine, S. Karger AG, Vol. 23, No. 3 ( 2016), p. 145-146
    Type of Medium: Online Resource
    ISSN: 1661-4119 , 1661-4127
    URL: Article
    DOI: 10.1159/000447314
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2016
    detail.hit.zdb_id: 2888724-4
    detail.hit.zdb_id: 1468807-4
    SSG: 15,3
    SSG: 5,21
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  • 4
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    Komplementäre Therapien in den Leitlinien für die Behandlung des Fibromyalgiesyndroms Update 2012
    S. Karger AG ; 2012
    In:  Forschende Komplementärmedizin / Research in Complementary Medicine Vol. 19, No. 6 ( 2012), p. 280-283
    Details
    In: Forschende Komplementärmedizin / Research in Complementary Medicine, S. Karger AG, Vol. 19, No. 6 ( 2012), p. 280-283
    Type of Medium: Online Resource
    ISSN: 1661-4127 , 1661-4119
    URL: Article
    DOI: 10.1159/000346147
    RVK:
    XA 10000
    Language: German
    Publisher: S. Karger AG
    Publication Date: 2012
    detail.hit.zdb_id: 2888724-4
    detail.hit.zdb_id: 1468807-4
    SSG: 15,3
    SSG: 5,21
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  • 5
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    Online Resource
    Effects of Mind-Body Therapy on Quality of Life and Neuroendocrine and Cellular Immune Functions in Patients with Ulcerative Colitis
    S. Karger AG ; 2005
    In:  Psychotherapy and Psychosomatics Vol. 74, No. 5 ( 2005), p. 277-287
    Details
    In: Psychotherapy and Psychosomatics, S. Karger AG, Vol. 74, No. 5 ( 2005), p. 277-287
    Abstract: 〈 i 〉 Background: 〈 /i 〉 The aim of this study was to investigate the effects of mind-body therapy on neuroendocrine and cellular immune measures, health-related quality of life and disease activity in patients with ulcerative colitis (UC) in remission. 〈 i 〉 Methods: 〈 /i 〉 Thirty UC patients in remission or with low disease activity were randomly assigned to an intervention group (n = 15) or a usual-care waiting control group (n = 15). Intervention consisted of a structured 60-hour training program over 10 weeks which included stress management training, moderate exercise, Mediterranean diet, behavioral techniques and self-care strategies. Quality of life, perceived stress and disease activity were assessed with standardized questionnaires (IBDQ, SF-36, PSS, CAI). In addition, the distribution of circulating lymphocytes and lymphocyte subsets as well as the β-adrenergic modulation of TNF-α production in vitro were analyzed. Urine catecholamines and plasma cortisol, prolactin and growth hormone were measured pre- and postinterventionally, and were compared with a healthy control group (n = 10). 〈 i 〉 Results: 〈 /i 〉 In response to therapy, patients in the intervention group showed significantly greater improvement in the SF-36 scale Mental Health and the Psychological Health Sum score compared with changes observed in the usual-care waiting control group. Patients in the intervention group showed significantly greater improvement on the IBDQ scale Bowel Symptoms compared with the control group. However, no significant group differences in circulating lymphocyte subsets or endocrine parameters were observed in response to therapy. In addition, no significant effects of intervention on either the basal levels of TNF-α or the suppressive action of the β-adrenergic agonist isoproterenol on TNF-α production were observed. 〈 i 〉 Conclusion: 〈 /i 〉 Mind-body therapy may improve quality of life in patients with UC in remission, while no effects of therapy on clinical or physiological parameters were found, which may at least in part be related to selective patient recruitment.
    Type of Medium: Online Resource
    ISSN: 0033-3190 , 1423-0348
    URL: Article
    DOI: 10.1159/000086318
    RVK:
    CU 5500
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2005
    detail.hit.zdb_id: 1472321-9
    SSG: 5,2
    SSG: 15,3
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  • 6
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    Efficacy of Caraway Oil Poultices in Treating Irritable Bowel Syndrome - A Randomized Controlled Cross-Over Trial
    S. Karger AG ; 2015
    In:  Digestion Vol. 92, No. 1 ( 2015), p. 22-31
    Details
    In: Digestion, S. Karger AG, Vol. 92, No. 1 ( 2015), p. 22-31
    Abstract: 〈 b 〉 〈 i 〉 Background/Aim: 〈 /i 〉 〈 /b 〉 Irritable bowel syndrome (IBS) is a frequent gastrointestinal disorder, with only limited evidence regarding self-management approaches. This study tested the efficacy of caraway oil poultices (CarO) for treating IBS. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 This randomized controlled open-label cross-over trial included three treatment periods with hot CarO and hot olive oil poultice (OlivH) or nonheated poultices (OlivC) with olive oil as control interventions. Patients applied each intervention daily for 3 weeks. The primary outcome was symptom severity (IBS-SSS); secondary outcomes included responder rates (improvement ≥50 IBS-SSS), quality of life (EQ-5D, IBS-QOL), psychological distress (HADS), adequate relief, and safety. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 48 patients with IBS were included (40 females, 53.9 ± 14.4 years). A significant difference was found for symptom severity in favor of CarO compared to OlivC (difference -38.4, 95% CI -73.6, -3.1, p = 0.033), but not compared to OlivH (difference -24.3, 95% CI -56.5, 7.9, p = 0.139). Responder rates were highest for CarO compared to OlivH and OlivC (43.9, 20.0, 18.9%, respectively). Within the CarO, 51.8% reported adequate relief compared to 23.5% (OlivH) and 25.8% (OlivC). One adverse event (gastrointestinal infection) was reported during CarO. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Hot caraway oil poultices appear effective and safe, although their effects may be a result of the heat application. Patients reported highest levels of subjective benefit from caraway oil poultices, making their use appropriate in the self-management of IBS.
    Type of Medium: Online Resource
    ISSN: 0012-2823 , 1421-9867
    URL: Article
    DOI: 10.1159/000398790
    RVK:
    XA 40650
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2015
    detail.hit.zdb_id: 1482218-0
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  • 7
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    The Predictive Value of the Hydrogen Breath Test in the Diagnosis of Fructose Malabsorption
    S. Karger AG ; 2019
    In:  Digestion Vol. 99, No. 2 ( 2019), p. 140-147
    Details
    In: Digestion, S. Karger AG, Vol. 99, No. 2 ( 2019), p. 140-147
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Fructose malabsorption is commonly diagnosed by the hydrogen fructose (H 〈 sub 〉 2 〈 /sub 〉 ) breath test. However, the mechanisms behind fructose malabsorption in humans are not well understood and the clinical relevance of this test is considered controversial. Hence, the main aim of this study is to evaluate the predictive value of the H 〈 sub 〉 2 〈 /sub 〉 breath test. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Regarding exclusion criteria, the study enrolled 562 consecutive patients, enlisted to a gastroenterology clinic between 2009 and 2011 for testing malabsorption. In the final data analysis, 246 patients were included. Ecotrophologists used 3 categories to rate dietary success: complete response, partial response and no response to the diet. They also rated the occurrence of abdominal pain, diarrhoea and bloating during the H 〈 sub 〉 2 〈 /sub 〉 breath test. Ordinal regression analysis using SPSS was performed to evaluate whether H 〈 sub 〉 2 〈 /sub 〉 breath test results – measured as the maximum H 〈 sub 〉 2 〈 /sub 〉 level, the maximum increase in H 〈 sub 〉 2 〈 /sub 〉 , and the area under the curve (AUC) – predicted dietary success or failure. Correlation analyses were applied to test whether symptoms of fructose malabsorption correlated with the H 〈 sub 〉 2 〈 /sub 〉 breath test measures. Finally, we evaluated whether cut-off-values of 40 or 60 parts per million (ppm) serve better than the test measure of 20 ppm to diagnose fructose malabsorption. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 When a fructose-free diet was administered it was found that 103 patients (41.9%) were complete responders, 116 (47.2%) were partial responders and 27 (11%) were non-responders. The H 〈 sub 〉 2 〈 /sub 〉 breath test with the 20 ppm cut-off-value, that is, the maximum H 〈 sub 〉 2 〈 /sub 〉 level, the maximum increase in H 〈 sub 〉 2 〈 /sub 〉 , and the AUC did not predict dietary response (all 95% CI ns). This was also the case when using 40 or 60 ppm as cut-off-values (all 95% CI ns). Abdominal pain during the test correlated significantly with the AUC. Diarrhoea and bloating correlated significantly with the AUC, the maximum H 〈 sub 〉 2 〈 /sub 〉 level and the maximum increase in H 〈 sub 〉 2 〈 /sub 〉 ( 〈 i 〉 p 〈 /i 〉 & #x3c; 0.05). 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 The H 〈 sub 〉 2 〈 /sub 〉 breath test produced no predictive value for the fructose-free diet outcomes; its value as a predictive test is therefore questionable. However, the symptoms of fructose malabsorption correlated significantly with the H 〈 sub 〉 2 〈 /sub 〉 breath test measures, and this is an indication that there is at least a degree of validity of the H2 breath test beyond the simple detection or exclusion of fructose malabsorption.
    Type of Medium: Online Resource
    ISSN: 0012-2823 , 1421-9867
    URL: Article
    DOI: 10.1159/000489877
    RVK:
    XA 40650
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2019
    detail.hit.zdb_id: 1482218-0
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  • 8
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    Komplementäre, alternative und integrative Therapien in den medizinischen Leitlinien - die Leitlinie «Diagnostik und Therapie der Colitis ulcerosa» als Beispiel gelungener Integration
    S. Karger AG ; 2014
    In:  Complementary Medicine Research Vol. 21, No. 1 ( 2014), p. 4-6
    Details
    In: Complementary Medicine Research, S. Karger AG, Vol. 21, No. 1 ( 2014), p. 4-6
    Type of Medium: Online Resource
    ISSN: 2504-2092 , 2504-2106
    URL: Article
    DOI: 10.1159/000358577
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2014
    detail.hit.zdb_id: 2888724-4
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  • 9
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    Herbal Medicine for Cough: a Systematic Review and Meta-Analysis
    S. Karger AG ; 2015
    In:  Complementary Medicine Research Vol. 22, No. 6 ( 2015), p. 359-368
    Details
    In: Complementary Medicine Research, S. Karger AG, Vol. 22, No. 6 ( 2015), p. 359-368
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 The aim of this review was to systematically assess the literature on herbal medicine for cough as a symptom of upper respiratory tract infections and common cold. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 The Cochrane Library, Scopus, MEDLINE/PubMed, and Embase were searched through March 2012 for RCTs testing the effects of herbal medicine for cough. Risk of bias was assessed using the Cochrane tool. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 34 RCTs (N = 7,083) on 〈 i 〉 Pelargonium sidoides 〈 /i 〉 (11 RCTs), 〈 i 〉 Echinacea 〈 /i 〉 (8 RCTs), 〈 i 〉 Andrographis paniculata 〈 /i 〉 (6 RCTs), ivy/primrose/thyme (4 RCTs), essential oils (4 RCTs) and bakumondoto (1 RCT) were included. Controls were mainly placebo. Most studies had a low risk of bias. The meta-analysis revealed strong evidence for 〈 i 〉 A. paniculata 〈 /i 〉 (SMD = -1.00, 95% CI = -1.85, -0.15; P 〈 0.001) and ivy/primrose/thyme (RR = 1.40, 95% CI = 1.23, 1.60; P 〈 0.001) in treating cough; moderate evidence for 〈 i 〉 P. sidiodes 〈 /i 〉 (RR = 4.60; 95% CI = 2.89,7.31; P 〈 0.001), and limited evidence for 〈 i 〉 Echinacea 〈 /i 〉 (SMD = -0.68; 95% CI = -1.32, -0.04; P = 0.04). 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 This review found strong evidence for 〈 i 〉 A. paniculata 〈 /i 〉 and ivy/primrose/thyme-based preparations and moderate evidence for 〈 i 〉 P. sidoides 〈 /i 〉 being significantly superior to placebo in alleviating the frequency and severity of patients' cough symptoms. Additional research, including other herbal treatments, is needed in this area.
    Type of Medium: Online Resource
    ISSN: 2504-2092 , 2504-2106
    URL: Article
    DOI: 10.1159/000442111
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2015
    detail.hit.zdb_id: 2888724-4
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  • 10
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    A Systematic Review of Phytotherapy for Acute Rhinosinusitis
    S. Karger AG ; 2016
    In:  Complementary Medicine Research Vol. 23, No. 3 ( 2016), p. 165-169
    Details
    In: Complementary Medicine Research, S. Karger AG, Vol. 23, No. 3 ( 2016), p. 165-169
    Abstract: Herbal medicine is a promising alternative in the treatment of acute rhinosinusitis (ARS). We performed a systematic review for phytopharmaceutical treatments of ARS. A computerized search of databases (Cochrane Library, PubMed, and Scopus) up to 16 September 2015 was performed. Randomized controlled trials (RCTs) and controlled trials (CTs) were included and assessed using the Cochrane risk of bias tool. Seven trials on 〈 i 〉 Pelargonium sidoides 〈 /i 〉 (EPs 7630, Umckaloabo®), Myrtol (GeloMyrtol® forte), BNO 1016 (Sinupret® extract), BNO 101 (Sinupret®), 〈 i 〉 Cyclamen europaeum 〈 /i 〉 (Nasodren®), and Esberitox® were included. Risk of bias was heterogeneous. EPs 7630 appeared to be useful in the treatment of ARS. Myrtol showed benefits against a placebo compound, and BNO 1016 and BNO 101 might be helpful; however, there was little evidence for the effectiveness of 〈 i 〉 Cyclamen europaeum 〈 /i 〉 and Esberitox®. Herbal medicine might be effective for the treatment of ARS, but given the low number of clinical trials and the heterogeneous methodological quality, further research is necessary.
    Type of Medium: Online Resource
    ISSN: 2504-2092 , 2504-2106
    URL: Article
    DOI: 10.1159/000447467
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2016
    detail.hit.zdb_id: 2888724-4
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