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  • S. Karger AG  (8)
  • 1
    Online-Ressource
    Online-Ressource
    Oral Supplementation of L-Arginine Prevents Chronic Cyclosporine Nephrotoxicity in Rats
    S. Karger AG ; 1998
    In:  Nephron Experimental Nephrology Vol. 6, No. 1 ( 1998-2-4), p. 50-56
    Details
    In: Nephron Experimental Nephrology, S. Karger AG, Vol. 6, No. 1 ( 1998-2-4), p. 50-56
    Kurzfassung: This study was performed to evaluate the effect of 〈 i 〉 L 〈 /i 〉 -arginine ( 〈 i 〉 L 〈 /i 〉 -Arg) on the prevention of chronic cyclosporine (CsA) nephrotoxicity in rats. Rats pair-fed a low-salt diet (0.05%) were given CsA (15 mg/kg/day s.c.), CsA and 〈 i 〉 L 〈 /i 〉 -Arg ( 〈 i 〉 L 〈 /i 〉 -Arg group, 1.25 g/l water), CsA and N-nitro- 〈 i 〉 L 〈 /i 〉 -arginine methyl ester ( 〈 i 〉 L 〈 /i 〉 -NAME group, 70 mg/l water) or vehicle. After 28 days, the 〈 i 〉 L 〈 /i 〉 -Arg group had a higher glomerular filtration rate compared to the CsA (0.42±0.05 vs. 0.31±0.06 ml/min/100 g, p 〈 0.05) and the 〈 i 〉 L 〈 /i 〉 -NAME groups (vs. 0.19± 0.04 ml/min/100 g, p 〈 0.05) and a significantly lower serum creatinine level compared to the CsA (0.70±0.06 vs. 0.92±0.12 mg/dl, p 〈 0.05) and the 〈 i 〉 L 〈 /i 〉 -NAME groups (vs. 1.21±0.17 mg/dl, p 〈 0.05). The 〈 i 〉 L 〈 /i 〉 -Arg group had less fibrosis, tubular injury (TI), and arteriolopathy than the CsA (fibrosis 0.39±0.14 vs. 0.74±0.15; TI 1.3±0.3 vs. 2.0±0.1; arteriolopathy 33±7 vs. 48±17, p 〈 0.05, respectively) and the 〈 i 〉 L 〈 /i 〉 -NAME groups (fibrosis vs. 1.67±0.32, TI vs. 2.6±0.3, arteriolopathy vs. 63±10, p 〈 0.05, respectively). Plasma renin activity in the 〈 i 〉 L 〈 /i 〉 -Arg group was less than in the CsA (18±2 vs. 23±3 ng Ang I/ml/h, p 〈 0.05) and the 〈 i 〉 L 〈 /i 〉 -NAME groups (vs. 30±3 ng Ang I/ml/h, p 〈 0.05). Nitric oxide production in 〈 i 〉 L 〈 /i 〉 -Arg group was higher than in the CsA (24.2±1.7 vs. 11.1±1.5 µmol/24 h, p 〈 0.05) and the 〈 i 〉 L 〈 /i 〉 -NAME groups (vs. 8.4±1.0 µmol/24 h, p 〈 0.05). In conclusion, the nitric oxide pathway is associated with the pathogenesis of chronic CsA nephrotoxicity, and exogenous 〈 i 〉 L 〈 /i 〉 -Arg supplementation is effective in reducing chronic CsA nephrotoxicity in rats.
    Materialart: Online-Ressource
    ISSN: 1660-2129
    URL: Article
    DOI: 10.1159/000020504
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 1998
    ZDB Id: 2098337-2
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  • 2
    Online-Ressource
    Online-Ressource
    Indomethacin Treatment Decreases Renal Blood Flow Velocity in Human Neonates
    S. Karger AG ; 1999
    In:  Neonatology Vol. 76, No. 5 ( 1999), p. 261-265
    Details
    In: Neonatology, S. Karger AG, Vol. 76, No. 5 ( 1999), p. 261-265
    Kurzfassung: This study was designed to evaluate the effect of indomethacin (ID) on renal perfusion in 13 neonates with symptomatic patent ductus arteriosus (PDA). Serial blood flow velocity in the left renal artery was measured just before and at 10, 30, 45, 60, 75 and 90 min after ID administration. Serum creatinine (Cr), sodium (Na), and osmolarity were measured just before, at 12 and 24 h, and at 3 days after ID administration. Timed urine also was collected for measurement of amount, fractional excretion of Na (FE 〈 sub 〉 Na 〈 /sub 〉 ), and creatinine clearance (C 〈 sub 〉 Cr 〈 /sub 〉 ). ID decreased end-diastolic flow velocity of renal artery and increased Pourcelot’s index, starting at 10 min and lasting for 75 min (p 〈 0.05). Serum Cr significantly increased at 12 h, and hourly urine output and C 〈 sub 〉 Cr 〈 /sub 〉 decreased for 24 h. Serum Na and osmolarity decreased for a period of at least 3 days (p 〈 0.05). FE 〈 sub 〉 Na 〈 /sub 〉 decreased at 12–24 h (p 〈 0.05). We conclude that ID treatment can induce significant renal dysfunction due to diminution of renal perfusion in human neonates.
    Materialart: Online-Ressource
    ISSN: 1661-7800 , 1661-7819
    URL: Article
    DOI: 10.1159/000014167
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 1999
    ZDB Id: 2403535-X
    SSG: 12
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  • 3
    Online-Ressource
    Online-Ressource
    Genetic Variants in Histone Modification Regions Predict Clinical Outcomes of Pemetrexed Chemotherapy in Lung Adenocarcinoma
    S. Karger AG ; 2023
    In:  Oncology Vol. 101, No. 2 ( 2023), p. 96-104
    Details
    In: Oncology, S. Karger AG, Vol. 101, No. 2 ( 2023), p. 96-104
    Kurzfassung: 〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 This study was conducted to investigate the association between genetic variants in histone modification regions and clinical outcomes of PEM chemotherapy in patients with lung adenocarcinoma. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Potentially functional SNPs were selected using integrated analysis of ChIP-seq and RNA-seq. The associations of 279 SNPs with chemotherapy response and overall survival (OS) were analyzed in 314 lung adenocarcinoma patients who underwent PEM chemotherapy. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Among the SNPs investigated, 18 were significantly associated with response to chemotherapy, while 28 with OS. Of these SNPs, rs549794A & #x3e;G in an enhancer which is expected to regulate the expression of 〈 i 〉 ribosomal protein S3 〈 /i 〉 ( 〈 i 〉 RPS3 〈 /i 〉 ) gene was significantly associated with both worse response to chemotherapy and worse OS (adjusted odds ratio = 0.59, 95% CI = 0.36–0.97, 〈 i 〉 p 〈 /i 〉 = 0.04; adjusted hazard ratio = 1.44, 95% CI = 1.09–1.91, 〈 i 〉 p 〈 /i 〉 = 0.01, respectively). Previous studies suggested that RPS3, a multi-functional protein with various extraribosomal activities, may play a role in chemotherapy resistance. Therefore, it is postulated that rs549794-induced change in the expression level of RPS3 may affect the response to PEM chemotherapy and consequently the survival outcomes in lung adenocarcinoma patients. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 This study suggests that genetic variants in the histone modification regions may be useful for the prediction of clinical outcomes of PEM chemotherapy in advanced lung adenocarcinoma.
    Materialart: Online-Ressource
    ISSN: 0030-2414 , 1423-0232
    URL: Article
    DOI: 10.1159/000527492
    RVK:
    XH 3305
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 2023
    ZDB Id: 1483096-6
    ZDB Id: 250101-6
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  • 4
    Online-Ressource
    Online-Ressource
    Polymorphisms in Matrix Metalloproteinase-1, -9 and -12 Genes and the Risk of Chronic Obstructive Pulmonary Disease in a Korean Population
    S. Karger AG ; 2010
    In:  Respiration Vol. 80, No. 2 ( 2010), p. 133-138
    Details
    In: Respiration, S. Karger AG, Vol. 80, No. 2 ( 2010), p. 133-138
    Kurzfassung: 〈 i 〉 Background: 〈 /i 〉 Although a few studies have been conducted to evaluate the association of polymorphisms in matrix metalloproteinase 〈 i 〉 (MMP) 〈 /i 〉 genes with chronic obstructive pulmonary disease (COPD), the results have been inconsistent. 〈 i 〉 Objectives: 〈 /i 〉 To investigate the association of 3 polymorphisms of 〈 i 〉 MMP 〈 /i 〉 genes ( 〈 i 〉 MMP-1 〈 /i 〉 –1607G→GG, 〈 i 〉 MMP-9 〈 /i 〉 –1562C→T and 〈 i 〉 MMP-12 〈 /i 〉 N357S), which have been reported to be associated with COPD-related phenotypes, with the risk of COPD in a Korean population. 〈 i 〉 Methods: 〈 /i 〉 The genotypes of the 3 polymorphisms were determined in 301 patients with COPD and 333 healthy controls. 〈 i 〉 Results: 〈 /i 〉 Of the 3 polymorphisms studied, only the distribution of the 〈 i 〉 MMP-9 〈 /i 〉 –1562C→T genotypes was significantly different between the cases and controls (p = 0.01), with the frequency of the variant T allele being significantly lower in the cases than in the controls (10.4 vs. 15.7%; p = 0.006). Individuals with at least 1 variant T allele were at a significantly decreased risk of COPD when compared with those with homozygous wild-type alleles (adjusted odds ratio = 0.69; 95% CI = 0.45–0.98; p = 0.04). 〈 i 〉 Conclusions: 〈 /i 〉 These findings suggest that the 〈 i 〉 MMP-9 〈 /i 〉 –1562C→T polymorphism could be used as a marker for determining the genetic susceptibility to COPD in a Korean population.
    Materialart: Online-Ressource
    ISSN: 0025-7931 , 1423-0356
    URL: Article
    DOI: 10.1159/000284926
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 2010
    ZDB Id: 1464419-8
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  • 5
    Online-Ressource
    Online-Ressource
    The Phosphotransferase System of 〈i〉Corynebacterium glutamicum〈/i〉: Features of Sugar Transport and Carbon Regulation
    S. Karger AG ; 2007
    In:  Microbial Physiology Vol. 12, No. 1-2 ( 2007), p. 43-50
    Details
    In: Microbial Physiology, S. Karger AG, Vol. 12, No. 1-2 ( 2007), p. 43-50
    Kurzfassung: In this review, we describe the phosphotransferase system (PTS) of 〈 i 〉 Corynebacterium glutamicum 〈 /i 〉 and discuss genes for putative global carbon regulation associated with the PTS. 〈 i 〉 C. glutamicum 〈 /i 〉 ATCC 13032 has PTS genes encoding the general phosphotransferases enzyme I, HPr and four enzyme II permeases, specific for glucose, fructose, sucrose and one yet unknown substrate. 〈 i 〉 C. gluamicum 〈 /i 〉 has a peculiar sugar transport system involving fructose efflux after hydrolyzing sucrose transported via sucrose EII. Also, in addition to their primary PTS, fructose and glucose are each transported by a second transporter, glucose EII and a non-PTS permease, respectively. Interestingly, 〈 i 〉 C. glutamicum 〈 /i 〉 does not show any preference for glucose, and thus co-metabolizes glucose with other sugars or organic acids. Studies on PTS-mediated sugar uptake and its related regulation in 〈 i 〉 C. glutamicum 〈 /i 〉 are important because the production yield of lysine and cell growth are dependent on the PTS sugars used as substrates for fermentation. In many bacteria, the PTS is also involved in several regulatory processes. However, the detailed molecular mechanism of global carbon regulation associated with the PTS in this organism has not yet been revealed.
    Materialart: Online-Ressource
    ISSN: 2673-1665 , 2673-1673
    URL: Article
    DOI: 10.1159/000096458
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 2007
    ZDB Id: 3042601-7
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  • 6
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    Polymorphisms in Glycolysis-Related Genes Are Associated with Clinical Outcomes of Paclitaxel-Cisplatin Chemotherapy in Non-Small Cell Lung Cancer
    S. Karger AG ; 2020
    In:  Oncology Vol. 98, No. 7 ( 2020), p. 468-477
    Details
    In: Oncology, S. Karger AG, Vol. 98, No. 7 ( 2020), p. 468-477
    Kurzfassung: 〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 This study was conducted to investigate whether polymorphisms in glycolysis-related genes are associated with clinical outcomes of patients with advanced-stage non-small cell lung cancer (NSCLC) undergoing chemotherapy. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 A total of 377 patients with NSCLC were enrolled. Sixty-five single-nucleotide polymorphisms in 26 genes involved in the glycolytic pathway were evaluated. The associations of the variants with the chemotherapy response and overall survival (OS) were analyzed. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Among the 65 variants investigated, 〈 i 〉 PFKL 〈 /i 〉 rs2073436C & #x3e;G and 〈 i 〉 GPI 〈 /i 〉 rs7248411C & #x3e;G significantly correlated with clinical outcomes after chemotherapy in multivariate analyses. 〈 i 〉 PFKL 〈 /i 〉 rs2073436C & #x3e;G was significantly associated with both a worse response to chemotherapy (adjusted odds ratio [aOR] = 0.64, 95% CI = 0.45–0.90, 〈 i 〉 p 〈 /i 〉 = 0.01) and a worse OS (adjusted hazard ratio [aHR] = 1.35, 95% CI = 1.14–1.61, 〈 i 〉 p 〈 /i 〉 = 0.001). 〈 i 〉 GPI 〈 /i 〉 rs7248411C & #x3e;G was significantly associated with both a better chemotherapy response (aOR = 1.58, 95% CI = 1.07–2.23, 〈 i 〉 p 〈 /i 〉 = 0.02) and a better OS (aHR = 0.80, 95% CI = 0.66–0.98, 〈 i 〉 p 〈 /i 〉 = 0.03). When stratified by tumor histology, 〈 i 〉 PFKL 〈 /i 〉 rs2073436C & #x3e;G was significantly associated with OS only in squamous cell carcinoma, whereas 〈 i 〉 GPI 〈 /i 〉 rs7248411C & #x3e;G exhibited a significant association with the chemotherapy response and OS only in adenocarcinoma. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 This result suggests that the 〈 i 〉 PFKL 〈 /i 〉 rs2073436C & #x3e;G and 〈 i 〉 GPI 〈 /i 〉 rs7248411C & #x3e;G are useful for predicting the clinical outcome of first-line paclitaxel-cisplatin chemotherapy in NSCLC.
    Materialart: Online-Ressource
    ISSN: 0030-2414 , 1423-0232
    URL: Article
    DOI: 10.1159/000504175
    RVK:
    XH 3305
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 2020
    ZDB Id: 1483096-6
    ZDB Id: 250101-6
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  • 7
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    Online-Ressource
    Genetic Variants in One-Carbon Metabolism Pathway Predict Survival Outcomes of Early-Stage Non-Small Cell Lung Cancer
    S. Karger AG ; 2020
    In:  Oncology Vol. 98, No. 12 ( 2020), p. 897-904
    Details
    In: Oncology, S. Karger AG, Vol. 98, No. 12 ( 2020), p. 897-904
    Kurzfassung: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 This study was conducted to investigate the association between genetic variants in one-carbon metabolism and survival outcomes of surgically resected non-small cell lung cancer (NSCLC). 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 We genotyped 41 potentially functional variants of 19 key genes in the one-carbon metabolism pathway among 750 NSCLC patients who underwent curative surgery. The association between genetic variants and overall survival (OS)/disease-free survival (DFS) were analyzed. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Among the 41 single-nucleotide polymorphisms (SNPs) analyzed, 4 SNPs ( 〈 i 〉 MTHFD1L 〈 /i 〉 rs6919680T & #x3e;G and rs3849794T & #x3e;C, 〈 i 〉 MTR 〈 /i 〉 rs2853523C & #x3e;A, and 〈 i 〉 MTHFR 〈 /i 〉 rs4846049G & #x3e;T) were significantly associated with survival outcomes. 〈 i 〉 MTHFD1L 〈 /i 〉 rs6919680T & #x3e;G and 〈 i 〉 MTR 〈 /i 〉 rs2853523C & #x3e;A were significantly associated with better OS (adjusted hazard ratio [aHR] = 0.73, 95% confidence interval [CI] = 0.54–0.99, 〈 i 〉 p 〈 /i 〉 = 0.04) and worse OS (aHR = 2.14, 95% CI = 1.13–4.07, 〈 i 〉 p 〈 /i 〉 = 0.02), respectively. 〈 i 〉 MTHFD1L 〈 /i 〉 rs3849794T & #x3e;C and 〈 i 〉 MTHFR 〈 /i 〉 rs4846049G & #x3e;T were significantly associated with worse DFS (aHR = 1.41, 95% CI = 1.08–1.83, 〈 i 〉 p 〈 /i 〉 = 0.01; and aHR = 1.97, 95% CI = 1.10–3.53, 〈 i 〉 p 〈 /i 〉 = 0.02, respectively). When the patients were divided according to histology, the associations were significant only in squamous cell carcinoma (SCC), but not in adenocarcinoma (AC). In SCC, 〈 i 〉 MTHFD1L 〈 /i 〉 rs6919680T & #x3e;G and 〈 i 〉 MTR 〈 /i 〉 rs2853523C & #x3e;A were significantly associated with better OS (aHR = 0.64, 95% CI = 0.41–1.00, 〈 i 〉 p 〈 /i 〉 = 0.05) and worse OS (aHR = 2.77, 95% CI = 1.11–6.91, 〈 i 〉 p 〈 /i 〉 = 0.03), respectively, and 〈 i 〉 MTHFD1L 〈 /i 〉 rs3849794T & #x3e;C and 〈 i 〉 MTHFR 〈 /i 〉 rs4846049G & #x3e;T were significantly associated with worse DFS (aHR = 1.73, 95% CI = 1.17–2.56, 〈 i 〉 p 〈 /i 〉 = 0.01; and aHR = 2.78, 95% CI = 1.12–6.88, 〈 i 〉 p 〈 /i 〉 = 0.03, respectively). 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Our results suggest that the genetic variants in the one-carbon metabolism pathway could be used as biomarkers for predicting the clinical outcomes of patients with early-stage NSCLC.
    Materialart: Online-Ressource
    ISSN: 0030-2414 , 1423-0232
    URL: Article
    DOI: 10.1159/000509658
    RVK:
    XH 3305
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 2020
    ZDB Id: 1483096-6
    ZDB Id: 250101-6
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  • 8
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    Analysis of Urine Cytology Tests in 120 Paired Cases
    S. Karger AG ; 2007
    In:  Acta Cytologica Vol. 51, No. 5 ( 2007), p. 782-787
    Details
    In: Acta Cytologica, S. Karger AG, Vol. 51, No. 5 ( 2007), p. 782-787
    Materialart: Online-Ressource
    ISSN: 1938-2650 , 0001-5547
    URL: Article
    DOI: 10.1159/000325842
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 2007
    ZDB Id: 2256676-4
    SSG: 12
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