In:
Fetal Diagnosis and Therapy, S. Karger AG, Vol. 46, No. 4 ( 2019), p. 257-265
Abstract:
〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 The false-positive rate in the prediction of fetal anemia is 10–15%. We investigated if a new, noninvasive MRI method used as a supplement to ultrasound could improve the prediction. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Fetuses suspected of anemia and controls were scanned in a 1.5-tesla MRI scanner 1–4 times during pregnancy. Cases were scanned before and after intrauterine blood transfusion with a T1-mapping MRI sequence in a cross-section of the umbilical vein. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Inclusion of 8 cases and 11 controls resulted in 10 case scans (2 cases were included twice) and 33 control scans. In controls, the T1 relaxation time was 1,005–1,391 ms; in cases with severe anemia, 1,505–1,595 ms, moderate anemia 1,503–1,525 ms, and no/mild anemia 1,245–1,410 ms. After blood transfusions, values dropped to 1,123–1,288 ms. The mean value in moderate and severe anemic cases was 275 ms higher than in controls (95% CI 210–341 ms, 〈 i 〉 p 〈 /i 〉 & #x3c; 0.0001), and after blood transfusion it was comparable to controls (3 ms, 95% CI –62 to 68 ms, 〈 i 〉 p 〈 /i 〉 = 0.934). A 1,450-ms cut-off would have identified all cases in need of blood transfusion with no false-positive cases. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Our findings indicate a potential for this new MRI method to improve the prediction of fetal anemia as a supplement to ultrasound.
Type of Medium:
Online Resource
ISSN:
1015-3837
,
1421-9964
Language:
English
Publisher:
S. Karger AG
Publication Date:
2019
detail.hit.zdb_id:
1482292-1
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