In:
Annals of Nutrition and Metabolism, S. Karger AG, Vol. 74, No. 2 ( 2019), p. 132-139
Abstract:
〈 b 〉 〈 i 〉 Background/Aims: 〈 /i 〉 〈 /b 〉 The mode of delivery (vaginal or cesarean section) and feeding type (breastfeeding or formula feeding) of neonates are considered the most influential factors in the development of gut microbiota. 〈 b 〉 〈 i 〉 Objectives: 〈 /i 〉 〈 /b 〉 This study investigated the effect of prebiotic-rich breast milk on overcoming gut microbiota dysbiosis. 〈 b 〉 〈 i 〉 Method: 〈 /i 〉 〈 /b 〉 Stool samples from 36 healthy Japanese neonates were obtained at 4 days and 1 month of age, and divided into 4 groups based on mode of delivery and feeding type. The gut microbiota composition and bacterial diversity were assessed using 16S rRNA sequencing. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 At 4 days old, vaginally delivered neonates had a significantly higher diversity of bacteria than those born by cesarean section. Bacteroidales and Enterobacteriales were overrepresented in vaginally delivered neonates ( 〈 i 〉 p 〈 /i 〉 = 0.0031 and 〈 i 〉 p 〈 /i 〉 = 0.011), while Bacillales and Lactobacillales were overrepresented in caesarean section delivered neonates ( 〈 i 〉 p 〈 /i 〉 = 0.012 and 〈 i 〉 p 〈 /i 〉 = 0.0016). However, there was little difference in bacterial diversity and bacterial relative abundance at 1 month of age between groups. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Cesarean section delivery appeared to reduce the diversity of neonate gut microbiota, resulting in dysbiosis, but this improved to the equivalent level seen in vaginally delivered infants by 1 month of age. Breastfeeding, even for short periods, may therefore improve neonate gut dysbiosis.
Type of Medium:
Online Resource
ISSN:
0250-6807
,
1421-9697
Language:
English
Publisher:
S. Karger AG
Publication Date:
2019
detail.hit.zdb_id:
1481977-6
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