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  • S. Karger AG  (7)
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  • S. Karger AG  (7)
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  • 1
    Online Resource
    Online Resource
    Clinical Manifestations and Management of Acute Thallium Poisoning
    S. Karger AG ; 2008
    In:  European Neurology Vol. 60, No. 6 ( 2008), p. 292-297
    Details
    In: European Neurology, S. Karger AG, Vol. 60, No. 6 ( 2008), p. 292-297
    Abstract: Clinical information regarding 3 patients diagnosed with acute thallium poisoning was collected and retrospectively analyzed. All 3 patients presented with severe burning pain in the lower limbs and the abdomen. Diffuse alopecia, hepatic dysfunction and Mees’ lines in the digits of each limb were observed between 2 and 3 weeks after onset. A physical examination demonstrated paresthesia of all 4 limbs, but normal deep tendon reflexes. Blood and urine thallium concentrations were significantly elevated. Treatment was initiated using hemoperfusion, hemodialysis, potassium supplementation, oral laxatives and B complex supplementation. Clinical symptoms improved as blood and urine thallium concentrations decreased, although a residual sensory neuropathy remained. This study demonstrated that the primary clinical manifestations of acute thallium poisoning include gastrointestinal symptoms, polyneuropathy and dermatological changes. Hemoperfusion and hemodialysis may be effective treatments for acute thallium poisoning.
    Type of Medium: Online Resource
    ISSN: 0014-3022 , 1421-9913
    URL: Article
    DOI: 10.1159/000157883
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2008
    detail.hit.zdb_id: 1482237-4
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  • 2
    Online Resource
    Online Resource
    Exenatide and Renal Outcomes in Patients with Type 2 Diabetes and Diabetic Kidney Disease
    S. Karger AG ; 2020
    In:  American Journal of Nephrology Vol. 51, No. 10 ( 2020), p. 806-814
    Details
    In: American Journal of Nephrology, S. Karger AG, Vol. 51, No. 10 ( 2020), p. 806-814
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Cardiovascular outcomes in clinical trials with type 2 diabetes mellitus (T2DM) patients have shown that glucagon-like peptide-1 receptor agonist can have a beneficial effect on the kidney. This trial aimed to assess the effects of exenatide on renal outcomes in patients with T2DM and diabetic kidney disease (DKD). 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 We performed a randomized parallel study encompassing 4 general hospitals. T2DM patients with an estimated glomerular filtration rate (eGFR) ≥30 mL/min/1.73 m 〈 sup 〉 2 〈 /sup 〉 and macroalbuminuria, defined as 24-h urinary albumin excretion rate (UAER) & #x3e;0.3 g/24 h were randomized 1:1 to receive exenatide twice daily plus insulin glargine (intervention group) or insulin lispro plus glargine (control group) for 24 weeks. The primary outcome was the UAER percentage change from the baseline after 24 weeks of intervention. The rates of hypoglycemia, adverse events (AEs), and change in eGFR during the follow-up were measured as safety outcomes. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Between March 2016 and April 2019, 92 patients were randomized and took at least 1 dose of the study drug. The mean age of the participants was 56 years. At baseline, the median UAER was 1,512.0 mg/24 h and mean eGFR was 70.4 mL/min/1.73 m 〈 sup 〉 2 〈 /sup 〉 . After 24 weeks of treatment, the UAER percentage change was significantly lower in the intervention group than in the control group ( 〈 i 〉 p 〈 /i 〉 = 0.0255). Moreover, the body weight declined by 1.3 kg in the intervention group (the difference between the 2 groups was 2.7 kg, 〈 i 〉 p 〈 /i 〉 = 0.0001). Compared to the control group, a lower frequency of hypoglycemia and more gastrointestinal AEs were observed in the intervention group. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Exenatide plus insulin glargine treatment for 24 weeks resulted in a reduction of albuminuria in T2DM patients with DKD.
    Type of Medium: Online Resource
    ISSN: 0250-8095 , 1421-9670
    URL: Article
    DOI: 10.1159/000510255
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2020
    detail.hit.zdb_id: 1468523-1
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  • 3
    Online Resource
    Online Resource
    Hearing Restoration for Adults with Vestibular Schwannoma in the Only Hearing Ear: Ipsilateral or Contralateral Cochlear Implantation?
    S. Karger AG ; 2016
    In:  ORL Vol. 78, No. 5 ( 2016), p. 281-288
    Details
    In: ORL, S. Karger AG, Vol. 78, No. 5 ( 2016), p. 281-288
    Abstract: 〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 To explore auditory outcomes following cochlear implantation (CI) in patients with vestibular schwannoma (VS) in the only hearing ear. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Three patients, all with a long history of hearing loss on one side and with newly diagnosed VS on the other side, underwent ipsilateral or contralateral CI. Their clinical data were collected retrospectively. Postoperative hearing outcomes were measured during follow-up and compared with the preoperative test results. A thorough search of the English-language literature was performed. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Patients 1 and 2 underwent CI in the ipsilateral and contralateral ear, respectively, without tumor removal; patient 3 underwent CI after tumor resection. At the last follow-up, the result of pure-tone audiometry was 25, 45, and 25 dB, respectively. An open-set speech discrimination score was achieved in all 3 patients, with monosyllabic word recognition of 60, 30, and 75%, respectively. Besides the patients included in our study, 28 CI cases with VS in the only hearing ear have been reported up to now. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 In patients with VS in the only hearing ear, significant hearing deterioration with no obvious tumor growth is a good indication for ipsilateral CI. Long-term deafness in the tumor-free ear is not an absolute contraindication for CI.
    Type of Medium: Online Resource
    ISSN: 0301-1569 , 1423-0275
    URL: Article
    DOI: 10.1159/000451003
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2016
    detail.hit.zdb_id: 1483533-2
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  • 4
    Online Resource
    Online Resource
    The Release of Cyclophilin A from Rapamycin-Stimulated Vascular Smooth Muscle Cells Mediated by Myosin II Activation: Involvement of Apoptosis but Not Autophagy
    S. Karger AG ; 2020
    In:  Journal of Vascular Research Vol. 57, No. 5 ( 2020), p. 254-260
    Details
    In: Journal of Vascular Research, S. Karger AG, Vol. 57, No. 5 ( 2020), p. 254-260
    Abstract: 〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 The exocytosis of cyclophilin A (CyPA) by a vesicular pathway in response to reactive oxygen species has been determined. However, other sources of extracellular CyPA remain obscure. 〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 The aim of this study was to determine the role of autophagy in the secretion of CyPA. 〈 b 〉 〈 i 〉 Methods and Results: 〈 /i 〉 〈 /b 〉 Rapamycin induced the activation of autophagy and release of CyPA from primary cultured rat aortic smooth muscle cells (RASMCs). However, inhibition of autophagy by knockdown of Atg7 or chloroquine did not affect the rapamycin-induced release of CyPA. With the exception of myosin II activity, rho-associated coiled-coil kinase (ROCK), actin remodelling, and synaptic vesicles were not implicated in the release of rapamycin-induced CyPA. Finally, we confirmed that rapamycin-induced extracellular CyPA originated from apoptotic RASMCs. Furthermore, the decreased activation of myosin II by blebbistatin blocked the release of CyPA from apoptotic RASMCs induced by rapamycin. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Rapamycin induced the release of CyPA from apoptotic RASMCs but did not affect exocytosis through autophagosomes. ROCK, actin remodelling, and synaptic vesicles were not involved in the apoptosis-related release of CyPA. Myosin II activation modulated the apoptosis of vascular smooth muscle cells and the release of CyPA from rapamycin-induced apoptotic cell death.
    Type of Medium: Online Resource
    ISSN: 1018-1172 , 1423-0135
    URL: Article
    DOI: 10.1159/000506685
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2020
    detail.hit.zdb_id: 1482726-8
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  • 5
    Online Resource
    Online Resource
    Neuropsychiatric Profiles of Patients with Insulinomas
    S. Karger AG ; 2010
    In:  European Neurology Vol. 63, No. 1 ( 2010), p. 48-51
    Details
    In: European Neurology, S. Karger AG, Vol. 63, No. 1 ( 2010), p. 48-51
    Abstract: 〈 i 〉 Background/Aims: 〈 /i 〉 Insulinoma is a rare and potentially curable disease. It is often misdiagnosed as neurological or psychiatric disorder. This study was performed to characterize the neuropsychiatric symptoms (PNS) of the patients with insulinoma from a regional clinical center. 〈 i 〉 Methods: 〈 /i 〉 All medical records of the patients with histopathologically identified insulinoma were reviewed during the period from 1998 to 2008. A case-control analysis was performed to compare the demographic data, details of clinical presentation, biochemical findings, tumor localization, and intraoperative findings between the patients with and without a prior misdiagnosis. 〈 i 〉 Results: 〈 /i 〉 Among 42 patients with insulinoma, 25 patients with PNS were initially misdiagnosed as having a neurological or psychiatric disease, while 17 patients with no PNS were correctly diagnosed. Most (64%) of PNS cases were not diagnosed correctly until 12 months after the first consultation. In patients with PNS that remained undiagnosed for at least 5 years, the most frequent symptoms were confusion, convulsion, and visual disturbances. Twelve cases of PNS were initially misdiagnosed as epilepsy and 3 of them showed epileptiform discharges on electroencephalography. 〈 i 〉 Conclusions: 〈 /i 〉 Episodic hypoglycemia induced by insulinoma can greatly mimic neurological and psychiatric presentation. A thorough history taking and inpatient assessment are necessary in evaluating recurrent neurological and psychiatric symptoms.
    Type of Medium: Online Resource
    ISSN: 0014-3022 , 1421-9913
    URL: Article
    DOI: 10.1159/000268166
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2010
    detail.hit.zdb_id: 1482237-4
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  • 6
    Online Resource
    Online Resource
    Lässt sich anhand von klinischen Variablen der Binokularfunktion die langfristige Stabilität der postoperativen Augenstellung nach Korrektur einer intermittierenden Exotropie vorhersagen?
    S. Karger AG ; 2020
    In:  Kompass Ophthalmologie Vol. 6, No. 4 ( 2020), p. 169-177
    Details
    In: Kompass Ophthalmologie, S. Karger AG, Vol. 6, No. 4 ( 2020), p. 169-177
    Abstract: Zielsetzung: Untersuchung, ob klinische Variablen der postoperativen Binokularfunktion die langfristige Stabilität der postoperativen Augenstellung nach Korrektur einer intermittierenden Exotropie bei Kindern vorhersagen können. Methode: Es erfolgte eine retrospektive Studie zu 39 Kindern (medianes Alter: 7 Jahre), die wegen einer intermittierenden Exotropie operativ behandelt worden waren und bei denen keine Überkorrektur erfolgt war (weniger als 10 Prismen-Dioptrien (PDPT) Exodeviation 1 Monat nach der Operation). Präoperativ sowie 1 Monat und 6 Monate nach der Operation und bei der letzten Nachuntersuchung (≥24 Monate) des Patienten wurden die Schielwinkel und Variablen der Binokularfunktion bestimmt. Wir untersuchten die Beziehung zwischen postoperativer Drift (Änderung der Augenstellung) und Variablen der Binokularfunktion (sensorische Funktion, konvergente Fusionsbreite und Stereosehschärfe). Ergebnisse: Die Erfolgsrate der Operation (Esophorie/-tropie ≤5 PDPT bis Exophorie/-tropie ≤10 PDPT) hatte 6 Monate nach der Operation auf 76,9% und zum Zeitpunkt der letzten Nachuntersuchungen der Patienten (im Mittel nach 37 Monaten) auf 53,8% abgenommen. Die mittlere Exodrift betrug zwischen 1 Monat nach der Operation und der letzten Nachuntersuchung bei Fernfixation 7,7 ± 9,2 PDPT ( 〈 i 〉 p 〈 /i 〉 & #x3c; 0,001). Die Stereosehschärfe in der Ferne, die zentrale Fusion und die konvergente Fusionsbreite verbesserten sich nach der Operation signifikant ( 〈 i 〉 p 〈 /i 〉 & #x3c; 0,05). Allerdings wurde keine signifikante Korrelation zwischen den Binokularfunktionen zu Beginn jeder Nachbeobachtungsphase und der postoperativen Drift beobachtet (alle 〈 i 〉 p 〈 /i 〉 & #x3e; 0,13). Schlussfolgerung: Unsere Beobachtungen weisen darauf hin, dass die klinischen Variablen sensorische Fusion, konvergente Fusionsbreite und Stereosehschärfe bei erfolgreich operierten Patienten, die 1 Monat nach der Operation keine Überkorrektur zeigen, nicht als robuste Prädiktoren für die langfristige Stabilität der postoperativen, korrigierten Augenstellung geeignet sind.
    Type of Medium: Online Resource
    ISSN: 2297-0118 , 2297-0045
    URL: Article
    DOI: 10.1159/000511471
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2020
    detail.hit.zdb_id: 2834706-7
    detail.hit.zdb_id: 3052375-8
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  • 7
    Online Resource
    Online Resource
    Immune Responses Mediated by Th17 Cells in 〈b〉〈i〉Helicobacter pylori 〈/i〉〈/b〉Infection
    S. Karger AG ; 2016
    In:  Integrative Medicine International Vol. 3, No. 1-2 ( 2016-7-9), p. 57-63
    Details
    In: Integrative Medicine International, S. Karger AG, Vol. 3, No. 1-2 ( 2016-7-9), p. 57-63
    Abstract: T helper 17 (Th17) cells are one of the CD4+ T-cell subsets which induce a variety of diseases by secreting IL-17 and other inflammatory factors. After 〈 i 〉 Helicobacter pylori 〈 /i 〉 (Hp) infection, cytotoxin-associated gene A and urease subunit B regulate the number of Th17 cells via induction of cell differentiation by infected macrophages, activation of MyD88 and other pathways, and by driving chemokines, which upregulates the number of both Th17 cells and regulatory T cells (Tregs) and switches towards a Treg-type immune response. Meanwhile, Th17 cells also play important roles in the response to Hp infection, participating in the clearance of Hp by recruiting neutrophils and expanding inflammatory response, causing mucosal damage and even inducing cancer. Thereby, Th17 cells participate in the occurrence and development of Hp-related diseases, such as gastritis, peptic ulcer disease and gastric cancer.
    Type of Medium: Online Resource
    ISSN: 2296-7362
    URL: Article
    DOI: 10.1159/000446317
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2016
    detail.hit.zdb_id: 2782059-2
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