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  • 1
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    Online Resource
    Preventive Effects of Alprostadil Against Contrast-Induced Nephropathy Inpatients With Renal Insufficiency Undergoing Percutaneous Coronary Intervention
    SAGE Publications ; 2018
    In:  Angiology Vol. 69, No. 5 ( 2018-05), p. 393-399
    Details
    In: Angiology, SAGE Publications, Vol. 69, No. 5 ( 2018-05), p. 393-399
    Abstract: We investigated the preventive effect of alprostadil on contrast-induced nephropathy (CIN) in patients with renal insufficiency undergoing percutaneous coronary intervention (PCI). A total of 300 patients with creatinine clearance (crCl) ≤60 mL/min undergoing PCI were randomly assigned to alprostadil or a control group. The primary end point was the incidence of CIN defined as an increase in serum creatinine (Scr) levels by ≥0.5 mg/dL or≥ 25% after administration of the contrast media within 72 hours. The secondary end points were (1) changes in Scr and crCl within 72 hours and (2) the incidence of major adverse events during hospitalization. The incidence of CIN was 2.7% (4/150) in the alprostadil group, and 8.7% (13/150) in the control group (χ 2 = 5.05, P = .043).There was no difference regarding the incidence of major adverse events during hospitalization between the alprostadil group and control groups (2.7% vs 4.0%, P = .750). Multivariate logistic regression analysis showed that alprostadil was an independent protective factor for CIN (odds ratio = 0.136, 95% confidence interval: 0.020-0.944, P = .044). Prophylactic administration of alprostadil may prevent CIN in patients with renal insufficiency undergoing PCI.
    Type of Medium: Online Resource
    ISSN: 0003-3197 , 1940-1574
    URL: Article
    DOI: 10.1177/0003319717730942
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2065911-8
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  • 2
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    Online Resource
    Study on the preparation of zirconium hydroxide textile and its absorption and detoxification of chemical warfare agents
    SAGE Publications ; 2023
    In:  Textile Research Journal
    Details
    In: Textile Research Journal, SAGE Publications
    Abstract: Chemical warfare agents (CWAs) still threaten society and have been used in recent terrorist attacks. Various adsorbents have been developed to remove CWA droplets effectively from contaminated objects to protect against serious injury. In this project, a collection of textiles, zirconium hydroxide (ZH) combined with polyvinyl alcohol (PVA)-polyethylene glycol (PEG) or polyacrylonitrile (PAN), were prepared using electro-spinning. Results of scanning electron microscopy, X-ray diffraction and inductively coupled plasma optical emission spectroscopy indicated that ZH was uniformly distributed and attached in the interstices of the polymer fiber with a high Zr load ratio of 〉 24%. The wetting and absorption of ZH textiles to simulation agents such as 2-chloroethyl ethyl sulfide and dimethyl methylphosphate showed good performance in terms of absorption. The calculation results, where the absorption factor k a of each textile was a constant value, suggested they had excellent capacity of removing CWA droplets, such as bis(2-chloroethyl) sulfide (HD), S-2-(diisopropylamino) ethyl O-ethyl methylphosphonothioate (VX) and pinacolyl methylphosphonofluoridate (GD). The detoxification experiment showed that both textiles of ZH@PAN and PAN had optimum degradation of HD with half-lives of 84.5 min due to its fast natural hydrolysis of HD and good adsorption of HD on textile. For degradation of VX solution, ZH@PVA-PEG presented a strong degradation capability with an almost equal half-life of 64.5 min to ZH. ZH@PVA-PEG could also catalyze GD hydrolysis effectively with a half-life of 55.0 min. This work manifested the possibility for quick absorption of CWAs from contaminated objects with non-powder materials and a strong degradation ability.
    Type of Medium: Online Resource
    ISSN: 0040-5175 , 1746-7748
    URL: Article
    DOI: 10.1177/00405175231179502
    RVK:
    ZS 0001
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2209596-2
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  • 3
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    Online Resource
    Treatment of Malignant Gastric Outlet Obstruction with Metallic Stents : Assessment of Whether Gastrointestinal Position Alters Efficacy
    SAGE Publications ; 2012
    In:  Journal of Investigative Medicine Vol. 60, No. 7 ( 2012-10), p. 1027-1032
    Details
    In: Journal of Investigative Medicine, SAGE Publications, Vol. 60, No. 7 ( 2012-10), p. 1027-1032
    Abstract: Gastric outlet obstruction (GOO) is a late complication of advanced gastric, pancreatic, and duodenal cancer. Palliative treatment of the obstruction is the main aim of therapy for these patients. Self-expandable metal stents are used for treating GOO. From our experience, the placement of the stent across the pylorus is easier and makes the curve of stent better than when the stent is placed within the duodenal area. The purposes of this study were to assess the efficacy of stents placed in either the duodenal area or across the pyloric valve in relieving GOO symptoms and to evaluate whether the location of the stent affects treatment outcomes. Materials and Methods This was a retrospective single-site study of 44 patients with malignant GOO. Expanding metal stents were placed either across the pyloric valve (n = 22; group A) or in the duodenum area (n = 22; group B). Improvement in oral intake was monitored using the Gastric Outlet Obstruction Scoring System (GOOSS). The end of the study was death of the last enrolled patient or 6 months after enrollment of the last patient, or whatever came first. Results Stent implantation similarly improved the patients’ tolerance for food intake from baseline for both groups A and B (median [interquartile range]; 2 [2–3] and 2 [2–3], respectively). Patients in group B who received adjunctive chemotherapy had greater improvement in GOOSS and survival than patients in group B who did not have chemotherapy or any group A patients ( P 〈 0.05). Stent patency was not affected by stent position or chemotherapy. Conclusion Palliative treatment of GOO with placement of an expandable metal stent improved the tolerability of food intake. The location of stent across the pyloric valve or within the duodenum did not affect the efficacy of the procedure or stent patency.
    Type of Medium: Online Resource
    ISSN: 1081-5589 , 1708-8267
    URL: Article
    DOI: 10.2310/JIM.0b013e31826509c8
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
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  • 4
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    Clinical predictors for biochemical failure in patients with positive surgical margin after robotic-assisted radical prostatectomy
    SAGE Publications ; 2022
    In:  Tumori Journal Vol. 108, No. 3 ( 2022-06), p. 270-277
    Details
    In: Tumori Journal, SAGE Publications, Vol. 108, No. 3 ( 2022-06), p. 270-277
    Abstract: Patients with positive surgical margins (PSMs) after radical prostatectomy for localized prostate cancer have a higher risk of biochemical failure (BCF). We investigated the risk factors of BCF in patients with PSMs after robotic-assisted radical prostatectomy (RARP). Methods: We evaluated 462 patients who underwent RARP in a single medical center from 2006 through 2013. Of them, 61 with PSMs did not receive any treatment before BCF. Kaplan-Meier curve and Cox regression analysis were used to compare patients with (n = 19) and without (n = 41) BCF. Results: Overall, 13.2% of patients had PSMs, and of those, 31.7% experienced BCF during follow-up. The mean follow-up duration was 43.7 months (42.4 [non-BCF] vs 46.35 (BCF] , p = 0.51). In univariant analyses, the platelet to lymphocyte ratio (6.26 [non-BCF] vs 8.02 [BCF] , p = 0.04) differed statistically. When patients were grouped by pathologic grade ≦2 or ≧3 ( p = 0.004), the BCF-free survival rates differed significantly. Seminal vesicle invasion also differed significantly (5 [non-BCF] vs 7 [BCF] , p = 0.005). Patients with undetectable nadir prostate-specific antigen (PSA) after RARP (BCF rate 4/34) differed statistically from those with detectable PSA after RARP (BCF rate 15/26) ( p 〈 0.001). In the multivariate analysis, the platelet/lymphocyte (P/L) ratio, pathologic grade, and undetectable nadir PSA remained statistically significant. Conclusions: In patients who undergo RARP and have PSMs, P/L ratio 〉 9 preoperatively, pathologic grade ⩾3, and detectable nadir PSA after RARP should be considered adverse features. Early intervention such as salvage radiation therapy or androgen deprivation therapy should be offered to these patients.
    Type of Medium: Online Resource
    ISSN: 0300-8916 , 2038-2529
    URL: Article
    DOI: 10.1177/03008916211007928
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 280962-X
    detail.hit.zdb_id: 2267832-3
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  • 5
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    Capsaicin Acts Through Reducing P38 MAPK-Dependent Thymidylate Synthase Expression to Enhance 5-Fluorouracil-Induced Cytotoxicity in Human Lung Cancer Cells
    SAGE Publications ; 2021
    In:  Natural Product Communications Vol. 16, No. 2 ( 2021-02), p. 1934578X2199333-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 16, No. 2 ( 2021-02), p. 1934578X2199333-
    Abstract: Capsaicin, an ingredient of green and red bell peppers, shows anticancer activity in several malignant cell lines. Thymidylate synthase (TS) is a well-validated anticancer drug target in non-small cell lung cancer (NSCLC) cells. However, whether capsaicin and 5-fluorouracil (5-FU) induce synergistic cytotoxicity in NSCLC cells by regulating TS expression is unclear. This study investigated the cytotoxicity of capsaicin and 5-FU co-treatment on two hoursuman lung adenocarcinoma cell lines, H520 and H1703, and the underlying mechanisms. Capsaicin decreased TS expression in a p38 mitogen-activated protein kinase (MAPK) inactivation–dependent manner in H520 and H1703 cells. Enhancement of p38 MAPK activity by transfection with constitutive active mitogen-activated protein kinase kinase six vectors increased TS expression and cell survival. In addition, capsaicin and 5-FU co-treatment enhanced synergistic cytotoxicity and inhibited cell growth associated with TS downregulation and p38 MAPK inactivation in H520 and H1703 cells. Capsaicin and 5-FU co-treatment did not affect the cellular content of capsaicin. These results show that capsaicin may be combined with 5-FU to treat NSCLC.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X21993335
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2430442-6
    SSG: 15,3
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  • 6
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    Online Resource
    Impact of far-infrared ray exposure on the mechanical properties of unwounded skin of rats
    SAGE Publications ; 2010
    In:  Experimental Biology and Medicine Vol. 235, No. 8 ( 2010-08), p. 952-956
    Details
    In: Experimental Biology and Medicine, SAGE Publications, Vol. 235, No. 8 ( 2010-08), p. 952-956
    Abstract: Far-infrared ray (FIR) has been applied to promote growth, modulate sleep, speed up the healing of wounds and accelerate microcirculation. The action of FIR on wounds has been well established in previous studies. However, whether the same action also works on normal skin is unclear. Therefore, the aim of this study was to evaluate the impact of FIR exposure on the tensile strength (TS) and composition of unwounded skin. In this study, 84 Sprague–Dawley (SD) rats were randomly divided into control and FIR groups. The dorsum samples were harvested for mechanical testing and histological observation at one, two, four and six weeks. The TS in the control group had no significant difference for all durations. However, a steep increase in the TS occurred between one and two weeks ( P = 0.033) in the FIR group. The TS in the FIR group was found to be significantly higher than the TS in the control group at two weeks ( P = 0.049). From histological observation, capillary dilation and increased inflammatory cells around the capillaries were observed at one week in FIR-treated groups. However, the mild inflammatory changes vanished after two weeks. In conclusion, our results showed that FIR may induce inflammatory changes and enhance skin TS in the short term, but the effect diminished with time.
    Type of Medium: Online Resource
    ISSN: 1535-3702 , 1535-3699
    URL: Article
    DOI: 10.1258/ebm.2010.009372
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
    detail.hit.zdb_id: 2020856-X
    SSG: 12
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  • 7
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    Online Resource
    Body Mass Index Changes in Relation to Male Reproductive Hormones: Longitudinal Results From a Community-Based Cohort Study
    SAGE Publications ; 2021
    In:  American Journal of Men's Health Vol. 15, No. 5 ( 2021-09), p. 155798832110490-
    Details
    In: American Journal of Men's Health, SAGE Publications, Vol. 15, No. 5 ( 2021-09), p. 155798832110490-
    Abstract: The objective of the current study was to explore the relationship between longitudinal change in body mass index (BMI) and reproductive hormones in middle-aged and elderly Chinese men. A cohort study was conducted in a rural area of China. Local male residents aged 40–80 years were recruited at baseline in 2012 and were followed up in 2016. Information about weight, height, waist circumference, sex hormones, smoking status, and medical history were obtained. The change in BMI reported no significant relationship with the change in total testosterone (TT), calculated free testosterone (cFT), and bioavailable testosterone (BioT) in Pearson correlation analyses. When the change in BMI was divided into three groups—“great loss,” “normal fluctuation,” and “great gain”—TT, cFT and BioT had the highest increase (or the lowest decrease) in men with “normal fluctuation” in BMI compared with the other two groups. The advantage of maintaining a stable BMI was more evident for those who were overweight, non-smoking, and disease-free. There was a tendency of a continuous increase in cFT and BioT with BMI increase in smoking and diseased populations. Maintaining a stable BMI is associated with maintaining normal levels of reproductive hormones, especially in overweight, non-smoking, and healthy men aged over 40 years.
    Type of Medium: Online Resource
    ISSN: 1557-9883 , 1557-9891
    URL: Article
    DOI: 10.1177/15579883211049044
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2275106-3
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  • 8
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    Online Resource
    Kane’s method applied to the simulation of a vehicle occupant in side impact
    SAGE Publications ; 2012
    In:  Proceedings of the Institution of Mechanical Engineers, Part K: Journal of Multi-body Dynamics Vol. 226, No. 3 ( 2012-09), p. 183-196
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part K: Journal of Multi-body Dynamics, SAGE Publications, Vol. 226, No. 3 ( 2012-09), p. 183-196
    Abstract: For measuring the response of vehicle occupants, dummy models were used to obtain fundamental information about the human body’s ability to withstand the crushing and tearing forces in a crash test. Various numerical dummy models that accurately simulate human response in crash simulations have been developed for research and development purposes. Multi-body dynamics analyses have recently been applied extensively to biodynamic modelling and to studies of the dynamic behaviour of bio-systems. This study presents three-dimensional 15-segment seated human body model and algorithm based on techniques developed in the study of rigid multi-body system dynamics. The dynamic response and injuries assessment of the vehicle occupant in a side impact was discussed. To confirm the accuracy of the proposed human body model and numerical procedure, the current results were compared with experimental data. The results indicate that the numerical method proposed in this study has considerable potential for evaluating a vehicle’s crash safety performance and guiding the future development of safety technologies.
    Type of Medium: Online Resource
    ISSN: 1464-4193 , 2041-3068
    URL: Article
    DOI: 10.1177/1464419312452468
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2032771-7
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  • 9
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    Online Resource
    Endometrial Glandular Dysplasia: A Putative Precursor Lesion of Uterine Papillary Serous Carcinoma. Part II: Molecular Features
    SAGE Publications ; 2004
    In:  International Journal of Surgical Pathology Vol. 12, No. 4 ( 2004-10), p. 319-331
    Details
    In: International Journal of Surgical Pathology, SAGE Publications, Vol. 12, No. 4 ( 2004-10), p. 319-331
    Abstract: Endometrial glandular dysplasia (EmGD) may be a newly defined precursor lesion of uterine papillary serous carcinoma (UPSC) by morphology. In this report, we studied molecular changes present in EmGD by the loss of heterozygosity (LOH) approach using laser capture microdissected tissue samples. Nineteen uteri showing at least 1 focus of EmGD by morphology were selected. These cases were 12 UPSC, 2 clear cell carcinomas, 1 mixed uterine papillary serous and endometrioid carcinoma, 1 uterine carcinosarcoma, 1 serous endometrial intraepithelial carcinoma (EIC), and 2 EmGD involving endometrial polyps. Seven microsatellite polymorphic DNA markers (TP53 at 17p, D1S211, and D1S162 at 1p32, D17S1323 at 17q21, D17S1330 at 17q25, D5S346 at 5q, and D2S123 at 2p) were utilized. A total of 123 laser-captured microdissection samples from 19 cases was studied with LOH method. The frequencies and patterns of LOH were analyzed and compared among benign resting endometrium (RE), EmGD, serous EIC, and UPSC. LOH was observed for at least 1 of the 7 markers in all categories of lesions, EmGD, serous EIC, and UPSC. The frequency of LOH for EmGD ranged from 4.2% to 31.3%; the range for serous EIC was 5.9% to 78.6%; and that for UPSC was 7.7% to 62.5%. The most frequent LOH in the 3 above-cited categories of lesions was identified at 17p (TP53) and 1p (D1S162). The frequency of LOH in EmGD with markers of TP53 and D1S162 was significantly higher than in RE (p 〈 0.05). With markers of D1S211 and D2S123, LOH in EmGD was higher than RE, approaching to a statistically significant level. Compared with foci of serous EIC and UPSC, however, the rate of LOH in EmGD was significantly lower only with TP53 locus (31.3% vs more than 60%, p 〈 0.05). The difference of LOH frequency with other chromosomal markers between EmGD and serous EIC/UPSC did not reach a statistically significant level. A significantly high concordant LOH pattern was found between foci of EmGD and serous EIC/UPSC (p = 0.05). We conclude that EmGD frequently shows LOH at multiple chromosomal loci, particularly at 17p and 1p. Significantly high concordant LOH frequency between EmGD and paired serous EIC or UPSC strongly suggests that EmGD is a noncancerous precursor lesion of UPSC, probably also of serous EIC. The clinical significance of EmGD needs further studies.
    Type of Medium: Online Resource
    ISSN: 1066-8969 , 1940-2465
    URL: Article
    DOI: 10.1177/106689690401200405
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2004
    detail.hit.zdb_id: 2070102-0
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  • 10
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    Online Resource
    A One-Step, Monolayer Culture and Chemical-Based Approach to Generate Insulin-Producing Cells From Human Adipose-Derived Stem Cells to Mitigate Hyperglycemia in STZ-Induced Diabetic Rats
    SAGE Publications ; 2022
    In:  Cell Transplantation Vol. 31 ( 2022-01), p. 096368972211069-
    Details
    In: Cell Transplantation, SAGE Publications, Vol. 31 ( 2022-01), p. 096368972211069-
    Abstract: The global population of individuals afflicted with diabetes mellitus has been increasing year by year, and this disease poses a serious threat to human health as well as the economies worldwide. Pancreatic or islet transplantations provide one of the most effective and long-term therapies available to treat diabetes, but the scarcity and quality of pancreatic islets limit their use in treatments. Here, we report the development of a one-step, monolayer culture, and chemical-based protocol that efficiently mediates the differentiation of human adipose-derived stem cells (hADSCs) into insulin-producing cells (IPCs). Our data indicate that hADSCs in monolayer culture that are allowed to differentiate into IPCs are superior to those in suspension cultures with respect to insulin secretion capacity (213-fold increase), cell viability (93.5 ± 3.27% vs. 41.67 ± 13.17%), and response to glucose stimulation. Moreover, the expression of genes associated with pancreatic lineage specification, such as PDX1, ISL1, and INS (encoding insulin), were expressed at significantly higher levels during our differentiation protocol (6-fold for PDX1 and ISL1, 11.5-fold for INS). Importantly, in vivo studies demonstrated that transplantation with IPCs significantly mitigated hyperglycemia in streptozotocin-induced diabetic rats. Our results indicate that this one-step, rapid protocol increases the efficiency of IPC generation and that the chemical-based approach for IPC induction may reduce safety concerns associated with the use of IPCs for clinical applications, thereby providing a safe and effective cell-based treatment for diabetes.
    Type of Medium: Online Resource
    ISSN: 0963-6897 , 1555-3892
    URL: Article
    DOI: 10.1177/09636897221106995
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2020466-8
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