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  • 1
    Online Resource
    Online Resource
    Pomalidomide desensitization for hypersensitivity: A case report
    SAGE Publications ; 2020
    In:  Journal of Oncology Pharmacy Practice Vol. 26, No. 5 ( 2020-07), p. 1244-1247
    Details
    In: Journal of Oncology Pharmacy Practice, SAGE Publications, Vol. 26, No. 5 ( 2020-07), p. 1244-1247
    Abstract: Pomalidomide is an immunomodulating agent that is used to treat relapsed and/or refractory multiple myeloma. Although the incidence of hypersensitivity with pomalidomide is not well documented, the most common type of hypersensitivity involves a cutaneous reaction. Previous reports have successfully utilized a desensitization protocol in patients who developed hypersensitivity to pomalidomide. Here we describe a case of a patient who developed urticaria on pomalidomide and successfully underwent a desensitization using the previously reported method in a case report. Case report A 68-year-old woman with relapsed multiple myeloma and no known drug allergies developed urticaria a day after taking the first dose of pomalidomide. Management and Outcome The patient underwent a 10-step desensitization process in the medical intensive care unit without any reported adverse events. The following day in the medical intensive care unit, the patient was able to tolerate a full dose of pomalidomide with no further reactions and was discharged with instructions to take a full dose of pomalidomide daily for 21 days out of a 28-day cycle. The patient was followed up in the outpatient clinic and noted no further reactions from pomalidomide at the three-month visit. Discussion The 10-step desensitization protocol with pomalidomide was well tolerated in the patient with hypersensitivity to pomalidomide. Whether this approach would work in patients with more severe reactions such as anaphylaxis and angioedema is still unknown.
    Type of Medium: Online Resource
    ISSN: 1078-1552 , 1477-092X
    URL: Article
    DOI: 10.1177/1078155219889676
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2026590-6
    SSG: 15,3
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  • 2
    Online Resource
    Online Resource
    Improved Survival and Reduced Clinical Progression in HIV-Infected Patients with Advanced Disease Treated with Saquinavir plus Zalcitabine
    SAGE Publications ; 1998
    In:  Antiviral Therapy Vol. 3, No. 1 ( 1998-01), p. 33-42
    Details
    In: Antiviral Therapy, SAGE Publications, Vol. 3, No. 1 ( 1998-01), p. 33-42
    Abstract: The objective of this randomized, double-blind, controlled multicentre study was to evaluate the efficacy of saquinavir alone or in combination with zalcitabine compared to zalcitabine monotherapy in reducing progression of human immunodeficiency virus (HIV) disease. Nine hundred and forty HIV-infected patients with more than 16 weeks of prior zidovudine therapy and pre-study entry CD4 cell counts between 50 and 300 cells/mm 3 were randomized to saquinavir 600 mg every 8 h, zalcitabine 0.75 mg every 8 h or the combination of both drugs. In an intent-to-treat analysis, the treatment arms were balanced with respect to demographics, baseline HIV RNA (mean 5.0 log 10 copies/ml) and CD4 lymphocyte count (mean 170 cells/mm 3 ). More patients in the zalcitabine arm stopped therapy because of toxicity than in the other two arms (25% versus 16%; P=0.005). Peripheral neuropathy was the most common treatment-limiting toxicity. Fifty-one patients in the saquinavir plus zalcitabine group developed an AIDS-defining event or died compared to 84 and 88 in the saquinavir and zalcitabine monotherapy groups respectively. Combination treatment with saquinavir plus zalcitabine reduced the risk of progression to AIDS by 49% (95% confidence interval 0.36 to 0.72, P=0.0001) and reduced death by 68% (95% confidence interval 0.16 to 0.64, P=0.001) compared to zalcitabine monotherapy. The addition of saquinavir to zalcitabine resulted in a significant reduction in progression to AIDS or death compared with zalcitabine alone.
    Type of Medium: Online Resource
    ISSN: 1359-6535 , 2040-2058
    URL: Article
    DOI: 10.1177/135965359800300103
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1998
    detail.hit.zdb_id: 2118396-X
    SSG: 15,3
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  • 3
    Online Resource
    Online Resource
    An analysis of measured and estimated creatinine clearance rates in normal weight, overweight, and obese patients with gynecologic cancers
    SAGE Publications ; 2012
    In:  Journal of Oncology Pharmacy Practice Vol. 18, No. 3 ( 2012-09), p. 323-332
    Details
    In: Journal of Oncology Pharmacy Practice, SAGE Publications, Vol. 18, No. 3 ( 2012-09), p. 323-332
    Abstract: Study objective: Different equations used to estimate creatinine clearance (Cl cr ) in obese oncology patients can produce divergent estimated creatinine clearance values, which in turn can result in significantly different calculated carboplatin doses. Standardization of the calculation of creatinine clearance in patients of all body types is a desirable goal. The objective of our study was to examine the impact of increasing body mass index on the accuracy of creatinine clearance estimation methods and to determine the optimal equation for creatinine clearance estimation in the obese adult female cancer patient. Design: Retrospective data analysis. Patients: We compared the estimated creatinine clearance values produced by each of 11 equations to 24-hour creatinine clearance values measured in 119 adult female patients with gynecologic cancers grouped according to body composition. Measurements and main results: We applied simple linear regression and Tukey mean-difference analysis to assess the relationship between estimated creatinine clearance values produced by these equations and measured creatinine clearance values for each patient. The relationship between measured creatinine clearance and estimated creatinine clearance produced by all equations displayed lower linear regression R 2 values and higher limits of agreement in obese patients than in nonobese groups. Agreement between measured and estimated creatinine clearance produced by the Cockcroft-Gault equation is sensitive to the particular weight parameter incorporated and is lowest using ideal weight or actual body weight. The Cockcroft-Gault equation incorporating an intermediate weight value reduced estimation bias. The Jelliffe equation produced the lowest R 2 values. Conclusion: Available model equations are less reliable for predicting creatinine clearance in obese female cancer patients (body mass index 〉 30) than in nonobese patients. A measured glomerular filtration rate or creatinine clearance value is most accurate in obese female cancer patients. When using Cockcroft-Gault equation for estimation in this patient population, however, an intermediate weight value (adjusted or modified-adjusted) rather than ideal or actual body weight should be used.
    Type of Medium: Online Resource
    ISSN: 1078-1552 , 1477-092X
    URL: Article
    DOI: 10.1177/1078155211435714
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2026590-6
    SSG: 15,3
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  • 4
    Online Resource
    Online Resource
    Factors Associated with Reduced Antituberculous Serum Drug Concentrations in Patients with HIV-TB Coinfection
    SAGE Publications ; 2012
    In:  Journal of the International Association of Physicians in AIDS Care Vol. 11, No. 5 ( 2012-10), p. 273-276
    Details
    In: Journal of the International Association of Physicians in AIDS Care, SAGE Publications, Vol. 11, No. 5 ( 2012-10), p. 273-276
    Abstract: We describe correlates of reduced antituberculous serum drug concentrations (SDCs) in HIV-infected patients receiving treatment for active tuberculosis (TB). Cross-sectional analysis of individuals diagnosed with HIV and active TB in Northern Alberta, Canada, was performed. Of the 30 HIV-TB cases, 27 underwent measurement of SDCs. Rates of low SDCs were 9 of 26 (34%) for isoniazid (INH) and 16 of 25 (64%) for rifamycins. Increased weight and elevated body mass index (BMI) correlated with low SDCs for rifampin ( P 〈 .05) and increased weight also correlated with reduced SDCs for INH ( P 〈 .05). This suggests that conventional antituberculous dosing may be too low and consideration should be given to increase the maximum initial weight-based doses in HIV-infected patients.
    Type of Medium: Online Resource
    ISSN: 1545-1097
    URL: Article
    DOI: 10.1177/1545109712454454
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2709037-1
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  • 5
    Online Resource
    Online Resource
    Underreporting of Musculoskeletal Injuries in the US Army : Findings From an Infantry Brigade Combat Team Survey Study
    SAGE Publications ; 2016
    In:  Sports Health: A Multidisciplinary Approach Vol. 8, No. 6 ( 2016-11), p. 507-513
    Details
    In: Sports Health: A Multidisciplinary Approach, SAGE Publications, Vol. 8, No. 6 ( 2016-11), p. 507-513
    Abstract: Musculoskeletal injury is a significant threat to readiness in the US Army. Current injury surveillance methods are constrained by accurate injury reporting. Input into electronic medical records or databases therefore may not accurately reflect injury incidence. The purpose of this study was to evaluate injury reporting among active-duty US Army soldiers to explore potential limitations of surveillance approaches. Hypothesis: A significant number of injuries go unreported to medical personnel. Study Design: Cross-sectional study. Level of Evidence: Level 4. Methods: Surveys were completed by soldiers assigned to an Army Infantry Brigade Combat Team. Survey questions inquired about injuries sustained in the previous 12 months, injury onset, and whether injuries were reported to a medical provider. Participants were asked to rank reasons for accurately reporting, underreporting, and/or exaggerating injuries. Chi-square analyses were used to compare differences among underreported injuries in terms of injury onset (gradual vs acute) and sex. Results: A total of 1388 soldiers reported 3202 injuries that had occurred in the previous 12-month period, including 1636 (51%) that were reported and 1566 (49%) that were identified as not reported to medical personnel. More than 49% of reported injuries were described as acute and 51% were described as chronic. Injury exaggeration was reported by 6% of soldiers. The most common reasons for not reporting injuries were fear that an injury might affect future career opportunities and avoidance of military “profiles” (mandated physical restrictions). Conclusion: Approximately half of musculoskeletal injuries in a Brigade Combat Team were not reported. Clinical Relevance: Unreported and untreated injuries can lead to reinjury, chronic pain, performance decrements, and increased costs associated with disability benefits. Additionally, unreported injuries can undermine injury surveillance efforts aimed at reducing the musculoskeletal injury problem in the military.
    Type of Medium: Online Resource
    ISSN: 1941-7381 , 1941-0921
    URL: Article
    DOI: 10.1177/1941738116670873
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2474978-3
    SSG: 31
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  • 6
    Online Resource
    Online Resource
    Sex Bias in Job Evaluation: The Effect of Sex on Judgments of Factor and Level Weights
    SAGE Publications ; 1987
    In:  Educational and Psychological Measurement Vol. 47, No. 2 ( 1987-06), p. 369-375
    Details
    In: Educational and Psychological Measurement, SAGE Publications, Vol. 47, No. 2 ( 1987-06), p. 369-375
    Abstract: Job evaluation instruments have recently been the subject of a number of critical reviews. In these reviews, job evaluation methods have been criticized for sex bias in the selection and weighting of factors. The present work investigated whether males and females differed in their ratings of importance on ten job evaluation factors and whether different weighting techniques would result in different wage structures. The results indicated that rater gender explained little of the variation in the ratings of the job evaluation factors.
    Type of Medium: Online Resource
    ISSN: 0013-1644 , 1552-3888
    URL: Article
    DOI: 10.1177/0013164487472009
    RVK:
    CL 1000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1987
    detail.hit.zdb_id: 1500101-5
    detail.hit.zdb_id: 206630-0
    SSG: 5,2
    SSG: 5,3
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  • 7
    Online Resource
    Online Resource
    The GrADS Project: Software Support for High-Level Grid Application Development
    SAGE Publications ; 2001
    In:  The International Journal of High Performance Computing Applications Vol. 15, No. 4 ( 2001-11), p. 327-344
    Details
    In: The International Journal of High Performance Computing Applications, SAGE Publications, Vol. 15, No. 4 ( 2001-11), p. 327-344
    Abstract: Advances in networking technologies will soon make it possible to use the global information infrastructure in a qualitatively different way—as a computational as well as an information resource. As described in the recent book The Grid: Blueprint for a New Computing Infrastructure, this Grid will connect the nation’s computers, databases, instruments, and people in a seamless web of computing and distributed intelligence, which can be used in an on-demand fashion as a problem-solving resource in many fields of human endeavor—and, in particular, science and engineering. The availability of grid resources will give rise to dramatically new classes of applications, in which computing resources are no longer localized but, rather, distributed, heterogeneous, and dynamic; computation is increasingly sophisticated and multidisciplinary; and computation is integrated into our daily lives and, hence, subject to stricter time constraints than at present. The impact of these new applications will be pervasive, ranging from new systems for scientific inquiry, through computing support for crisis management, to the use of ambient computing to enhance personal mobile computing environments. To realize this vision, significant scientific and technical obstacles must be overcome. Principal among these is usability. The goal of the Grid Application Development Software (GrADS) project is to simplify distributed heterogeneous computing in the same way that the World Wide Web simplified information sharing over the Internet. To that end, the project is exploring the scientific and technical problems that must be solved to make it easier for ordinary scientific users to develop, execute, and tune applications on the Grid. In this paper, the authors describe the vision and strategies underlying the GrADS project, including the base software architecture for grid execution and performance monitoring, strategies and tools for construction of applications from libraries of grid-aware components, and development of innovative new science and engineering applications that can exploit these new technologies to run effectively in grid environments.
    Type of Medium: Online Resource
    ISSN: 1094-3420 , 1741-2846
    URL: Article
    DOI: 10.1177/109434200101500401
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2001
    detail.hit.zdb_id: 2017480-9
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  • 8
    Online Resource
    Online Resource
    Comparison of Different Methods of Determining the Sex Type of an Occupation
    SAGE Publications ; 1985
    In:  Psychological Reports Vol. 57, No. 3 ( 1985-12), p. 747-750
    Details
    In: Psychological Reports, SAGE Publications, Vol. 57, No. 3 ( 1985-12), p. 747-750
    Abstract: The sex type of an occupation has been frequently investigated. Two major methods, actual rates of participation in the labor market and subjective estimates, have been used to determine the sex type of an occupation. The present study demonstrated that these two methods of estimating sex type may lead to different results.
    Type of Medium: Online Resource
    ISSN: 0033-2941 , 1558-691X
    URL: Article
    DOI: 10.2466/pr0.1985.57.3.747
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1985
    detail.hit.zdb_id: 2066930-6
    SSG: 5,2
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  • 9
    Online Resource
    Online Resource
    The Authors Reply
    SAGE Publications ; 1989
    In:  Annals of Clinical Biochemistry: International Journal of Laboratory Medicine Vol. 26, No. 3 ( 1989-05), p. 305-306
    Details
    In: Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, SAGE Publications, Vol. 26, No. 3 ( 1989-05), p. 305-306
    Type of Medium: Online Resource
    ISSN: 0004-5632 , 1758-1001
    URL: Article
    DOI: 10.1177/000456328902600329
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1989
    detail.hit.zdb_id: 2041298-8
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