In:
The Neuroscientist, SAGE Publications, Vol. 9, No. 3 ( 2003-06), p. 205-216
Abstract:
The clustering of neurotransmitter receptors at the postsynaptic terminals is a critical requirement for efficient neurotransmission and neuronal communication. This process is facilitated by adaptor proteins, which bridge the postsynaptic receptors and the underlying cytoskeleton. One such molecule, the GABA A receptor-associated protein, GABARAP, was identified as a potential linker between GABA A receptors and microtubules. GABARAP belongs to an expanding family of proteins that are implicated in a variety of intracellular transport processes. GABARAP has been shown to interact with myriad binding partners, including the γ2 subunit of the GABA A receptor, tubulin and microtubules, the N-ethyl maleimide sensitive factor, gephyrin, and the transferin receptor. The recent determination of the GABARAP crystal structure has revealed individual GABARAP domains, motifs, and surface regions involved in specific protein-protein interactions. Currently, a more general role is emerging for GABARAP, including shipping GABA A receptors to and from the cell surface, organizing them into postsynaptic clusters, and regulating the steady-state receptor density.
Type of Medium:
Online Resource
ISSN:
1073-8584
,
1089-4098
DOI:
10.1177/1073858403009003013
Language:
English
Publisher:
SAGE Publications
Publication Date:
2003
detail.hit.zdb_id:
2029471-2
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